Lei Chang

TL;DR: ThUBD is a refined and promising approach for enriching the ubiquitinated proteome while circumventing the need to overexpress tagged ubiquitin variants and use antibodies to recognize ubiquitIn remnants, thus providing a readily accessible tool for the protein ubiquitination research community.

TL;DR: This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application of urinary proteome in auxiliary diagnosis, severity determination and therapy development of CO VID-19.

TL;DR: Of the upregulated tumor-related proteins, minichromosome maintenance 2 (MCM2), a DNA replication licensing factor, was one of the most significantly altered proteins, and its overexpression was confirmed using tissue microarray and the first small molecule-based MCM2-targeted NIR-II probe CH1055-MCM 2 was concisely generated and subsequently evaluated in mice bearing HepG2 xenografts.

TL;DR: Evidence is provided that HBx induces the dysregulation of cytoskeleton remodeling and lipid metabolism and leads to the occurrence and development of liver cancer.

TL;DR: A quantitative proteomic analysis to investigate the mechanism of carbon ion irradiation on human AHH‐1 lymphoblastoid cells provided a novel target for cell self‐repair against heavy ion radiation‐induced cellular damage.