L
Lei Chang
Researcher at Protein Sciences
Publications - 51
Citations - 353
Lei Chang is an academic researcher from Protein Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 32 publications receiving 221 citations.
Papers
More filters
Journal ArticleDOI
Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs)
Yuan Gao,Yanchang Li,Chengpu Zhang,Mingzhi Zhao,Chen Deng,Qiuyan Lan,Zexian Liu,Na Su,Jingwei Wang,Feng Xu,Yongru Xu,Lingyan Ping,Lei Chang,Gao Huiying,Junzhu Wu,Yu Xue,Zixin Deng,Junmin Peng,Ping Xu +18 more
TL;DR: ThUBD is a refined and promising approach for enriching the ubiquitinated proteome while circumventing the need to overexpress tagged ubiquitin variants and use antibodies to recognize ubiquitIn remnants, thus providing a readily accessible tool for the protein ubiquitination research community.
Posted ContentDOI
Urine Proteome of COVID-19 Patients
Yanchang Li,Yihao Wang,Huiying Liu,Wei Sun,Baoqing Ding,Yinghua Zhao,Peiru Chen,Li Zhu,Zhaodi Li,Naikang Li,Lei Chang,Hengliang Wang,Changqing Bai,Ping Xu,Ping Xu +14 more
TL;DR: This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application of urinary proteome in auxiliary diagnosis, severity determination and therapy development of CO VID-19.
Journal ArticleDOI
Proteomic Analysis and NIR-II Imaging of MCM2 Protein in Hepatocellular Carcinoma
Jing Yang,Jing Yang,Xie Qi,Xie Qi,Hui Zhou,Lei Chang,Wei Wei,Wang Yin,Wang Yin,Hong Li,Zixin Deng,Yuling Xiao,Junzhu Wu,Ping Xu,Ping Xu,Ping Xu,Xuechuan Hong,Xuechuan Hong +17 more
TL;DR: Of the upregulated tumor-related proteins, minichromosome maintenance 2 (MCM2), a DNA replication licensing factor, was one of the most significantly altered proteins, and its overexpression was confirmed using tissue microarray and the first small molecule-based MCM2-targeted NIR-II probe CH1055-MCM 2 was concisely generated and subsequently evaluated in mice bearing HepG2 xenografts.
Journal ArticleDOI
Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism.
Zhongwei Xu,Linghui Zhai,Tailong Yi,Gao Huiying,Fengxu Fan,Yanchang Li,Youliang Wang,Ning Li,Xiaohua Xing,Na Su,Feilin Wu,Lei Chang,Xiuli Chen,Erhei Dai,Chao Zhao,Xiao Yang,Chunping Cui,Ping Xu +17 more
TL;DR: Evidence is provided that HBx induces the dysregulation of cytoskeleton remodeling and lipid metabolism and leads to the occurrence and development of liver cancer.
Journal ArticleDOI
Quantitative proteomics reveals mitochondrial respiratory chain as a dominant target for carbon ion radiation: Delayed reactive oxygen species generation caused DNA damage.
Peng-Cheng Fan,Yao Zhang,Yao Zhang,Yu Wang,Wei Wei,Yan-Xia Zhou,Yi Xie,Xin Wang,Yingzi Qi,Lei Chang,Zheng-Ping Jia,Zhe Zhou,Hua Guan,Hong Zhang,Ping Xu,Ping Xu,Ping-Kun Zhou +16 more
TL;DR: A quantitative proteomic analysis to investigate the mechanism of carbon ion irradiation on human AHH‐1 lymphoblastoid cells provided a novel target for cell self‐repair against heavy ion radiation‐induced cellular damage.