L
Leif Bertilsson
Researcher at Karolinska University Hospital
Publications - 321
Citations - 24620
Leif Bertilsson is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Debrisoquine & Debrisoquin. The author has an hindex of 87, co-authored 321 publications receiving 23933 citations. Previous affiliations of Leif Bertilsson include Astra & University of Oulu.
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Journal ArticleDOI
A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.
Sarah C. Sim,Sarah C. Sim,Carl Risinger,Carl Risinger,Marja-Liisa Dahl,Marja-Liisa Dahl,Eleni Aklillu,Eleni Aklillu,Magnus Christensen,Magnus Christensen,Leif Bertilsson,Leif Bertilsson,Magnus Ingelman-Sundberg,Magnus Ingelman-Sundberg +13 more
TL;DR: Many drugs, including proton pump inhibitors and certain antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP) 2C19 enzyme, and a significant portion of extensive metabolizers do not reach appropriate drug levels.
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Monoamine metabolites in CSF and suicidal behavior.
TL;DR: A follow-up study revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median, which was lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbr puncture.
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"Serotonin depression"--a biochemical subgroup within the affective disorders?
TL;DR: There was a significant correlation between the concnetration of 5-HIAA and severity of depression in the lower, but not in the upper, mode, which suggests the existence of a biochemical subgroup of depressive disorder, characterized by a disturbance of serotonin turnover.
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Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
Inger Johansson,Eva Lundqvist,Leif Bertilsson,Marja-Liisa Dahl,Folke Sjöqvist,Magnus Ingelman-Sundberg +5 more
TL;DR: The data show the principle of inherited amplification of an active gene, and the finding of a specific haplotype with two or more active CYP2D6 genes allows genotyping for ultrarapid drug metabolizers.
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Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs
TL;DR: The present-day knowledge on the influence of the genetic variability in CYP2D6 on the clinical pharmacokinetics and therapeutic effects/adverse effects of psychotropic drugs is reviewed.