L
Lena Dolman
Researcher at Ontario Institute for Cancer Research
Publications - 7
Citations - 479
Lena Dolman is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Data sharing & Internal medicine. The author has an hindex of 4, co-authored 6 publications receiving 311 citations.
Papers
More filters
Journal ArticleDOI
Integrating Genomics into Healthcare: A Global Responsibility
Zornitza Stark,Lena Dolman,Teri A. Manolio,Brad Ozenberger,Sue Hill,Mark J. Caulfied,Yves Levy,David Glazer,Julia Wilson,Mark Lawler,Tiffany Boughtwood,Jeffrey Braithwaite,Peter Goodhand,Ewan Birney,Kathryn N. North +14 more
TL;DR: This work reviews the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provides a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.
Journal ArticleDOI
BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2
Melissa S. Cline,Rachel G. Liao,Michael T. Parsons,Benedict Paten,Faisal Alquaddoomi,Antonis C. Antoniou,Samantha Baxter,Larry Brody,Robert Cook-Deegan,Amy Coffin,Fergus J. Couch,Brian Craft,Robert Currie,Chloe C Dlott,Lena Dolman,Johan T. den Dunnen,Stephanie O.M. Dyke,Susan M. Domchek,Douglas F. Easton,Zachary Fischmann,William D. Foulkes,Judy Garber,David E. Goldgar,Mary Goldman,Peter Goodhand,Seamus Conor Harrison,David Haussler,Kazuto Kato,Bartha Maria Knoppers,Charles Markello,Robert L. Nussbaum,Kenneth Offit,Sharon E. Plon,Jem Rashbass,Heidi L. Rehm,Heidi L. Rehm,Mark E. Robson,Wendy S. Rubinstein,Dominique Stoppa-Lyonnet,Sean V Tavtigian,Sean V Tavtigian,Adrian Thorogood,Can Zhang,Marc Zimmermann,John Burn,Stephen J. Chanock,Gunnar Rätsch,Amanda B. Spurdle +47 more
TL;DR: The BRCA Challenge has brought together the existing international Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium expert panel, along with expert clinicians, diagnosticians, researchers, and database providers, all with a common goal of advancing the understanding of BRC a1 and BRCa2 variation.
Journal ArticleDOI
Federated discovery and sharing of genomic data using Beacons.
Marc Fiume,Miroslav Cupak,Stephen Keenan,Jordi Rambla,Sabela de la Torre,Stephanie O.M. Dyke,Anthony J. Brookes,Knox Carey,David Lloyd,Peter Goodhand,Maximilian Haeussler,Michael Baudis,Michael Baudis,Heinz Stockinger,Lena Dolman,Ilkka Lappalainen,Ilkka Lappalainen,Juha Törnroos,Mikael Linden,J. Dylan Spalding,Saif Ur-Rehman,Angela Page,Paul Flicek,Paul Flicek,Stephen T. Sherry,David Haussler,Susheel Varma,Gary Saunders,Serena Scollen +28 more
TL;DR: The Beacon protocol is described and how it can be used as a model for the federated discovery and sharing of genomic data.
Journal ArticleDOI
ClinGen advancing genomic data-sharing standards as a GA4GH driver project.
Lena Dolman,Angela Page,Lawrence J. Babb,Robert R. Freimuth,Harindra Arachchi,Chris Bizon,Matthew H. Brush,Marc Fiume,Melissa A. Haendel,Melissa A. Haendel,David Hansen,Aleksandar Milosavljevic,Ronak Y. Patel,Piotr Pawliczek,Andrew D. Yates,Heidi L. Rehm,Heidi L. Rehm +16 more
TL;DR: ClinGen's participation as a GA4GH Driver Project will provide a robust environment to test drive emerging genomic knowledge sharing standards and prove their utility among the community, while accelerating the construction of the ClinGen evidence base.
Journal ArticleDOI
BRCA1/2 Variant Data-Sharing Practices.
TL;DR: This work describes current BRCA1/2 data-sharing practices, in the United States and globally, and discusses obstacles and incentives to sharing, based on 28 interviews with personnel at U.S. and non-U.s. clinical laboratories and databases.