L
Lennart Koepke
Researcher at University of Ulm
Publications - 32
Citations - 2034
Lennart Koepke is an academic researcher from University of Ulm. The author has contributed to research in topics: Innate immune system & Biology. The author has an hindex of 11, co-authored 26 publications receiving 751 citations.
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Journal ArticleDOI
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Jan Hendrik Straub,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +17 more
TL;DR: Structural characterization of the inhibitory mechanism of Nsp1 may aid structure-based drug design against SARS-CoV-2 and effectively blocks retinoic acid–inducible gene I–dependent innate immune responses that would otherwise facilitate clearance of the infection.
Journal ArticleDOI
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.
Janis A. Müller,Rüdiger Groß,Carina Conzelmann,Jana Krüger,Uta Merle,Johannes Steinhart,Tatjana Weil,Lennart Koepke,Caterina Prelli Bozzo,Clarissa Read,Giorgio Fois,Tim Eiseler,Julia Gehrmann,Joanne van Vuuren,Isabel M Wessbecher,Manfred Frick,Ivan G. Costa,Markus Breunig,Beate Grüner,Lynn Peters,Michael Schuster,Stefan Liebau,Thomas Seufferlein,Steffen Stenger,Albrecht Stenzinger,Patrick E. MacDonald,Frank Kirchhoff,Konstantin M. J. Sparrer,Paul Walther,Heiko Lickert,Thomas F. E. Barth,Martin Wagner,Jan Münch,Sandra Heller,Alexander Kleger +34 more
TL;DR: In this paper, the authors identify the human pancreas as a target of SARS-CoV-2 infection and suggest that β-cell infection could contribute to the metabolic dysregulation observed in patients with COVID-19.
Posted ContentDOI
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +16 more
TL;DR: It is shown that Nsp1 from SARS-CoV-2 binds to 40S and 80S ribosomes, resulting in shutdown of capped mRNA translation both in vitro and in cells, which effectively blocks RIG-I-dependent innate immune responses that would otherwise facilitate clearance of the infection.
Journal ArticleDOI
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Manuel Hayn,Maximilian Hirschenberger,Lennart Koepke,Rayhane Nchioua,Jan Hendrik Straub,Susanne Klute,Victoria Hunszinger,Fabian Zech,Caterina Prelli Bozzo,Wasim Aftab,Maria H Christensen,Carina Conzelmann,Janis A. Müller,Smitha Srinivasachar Badarinarayan,Christina M. Stürzel,Ignasi Forné,Steffen Stenger,Karl-Klaus Conzelmann,Jan Münch,Florian I. Schmidt,Daniel Sauter,Axel Imhof,Frank Kirchhoff,Konstantin Maria Johannes Sparrer +23 more
TL;DR: In this article, the authors systematically analyzed the impact of SARS-CoV-2 proteins on interferon (IFN) responses and autophagy, and they showed that SARS co-virus 2 proteins synergize to counteract anti-viral immune responses.
Journal ArticleDOI
Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?
Christoph Jung,Dorota Kmieć,Lennart Koepke,Fabian Zech,Timo Jacob,Konstantin M. J. Sparrer,Frank Kirchhoff +6 more
TL;DR: An overview of the mutations in the Omicron genome and the resulting changes in viral proteins compared to other SARS-CoV-2 strains and their potential functional consequences is provided.