M
Manuel Hayn
Researcher at University of Ulm
Publications - 14
Citations - 1073
Manuel Hayn is an academic researcher from University of Ulm. The author has contributed to research in topics: Innate immune system & Chemokine. The author has an hindex of 6, co-authored 12 publications receiving 473 citations.
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Journal ArticleDOI
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Jan Hendrik Straub,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +17 more
TL;DR: Structural characterization of the inhibitory mechanism of Nsp1 may aid structure-based drug design against SARS-CoV-2 and effectively blocks retinoic acid–inducible gene I–dependent innate immune responses that would otherwise facilitate clearance of the infection.
Posted ContentDOI
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +16 more
TL;DR: It is shown that Nsp1 from SARS-CoV-2 binds to 40S and 80S ribosomes, resulting in shutdown of capped mRNA translation both in vitro and in cells, which effectively blocks RIG-I-dependent innate immune responses that would otherwise facilitate clearance of the infection.
Journal ArticleDOI
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Manuel Hayn,Maximilian Hirschenberger,Lennart Koepke,Rayhane Nchioua,Jan Hendrik Straub,Susanne Klute,Victoria Hunszinger,Fabian Zech,Caterina Prelli Bozzo,Wasim Aftab,Maria H Christensen,Carina Conzelmann,Janis A. Müller,Smitha Srinivasachar Badarinarayan,Christina M. Stürzel,Ignasi Forné,Steffen Stenger,Karl-Klaus Conzelmann,Jan Münch,Florian I. Schmidt,Daniel Sauter,Axel Imhof,Frank Kirchhoff,Konstantin Maria Johannes Sparrer +23 more
TL;DR: In this article, the authors systematically analyzed the impact of SARS-CoV-2 proteins on interferon (IFN) responses and autophagy, and they showed that SARS co-virus 2 proteins synergize to counteract anti-viral immune responses.
Journal ArticleDOI
Manipulation of autophagy by SARS-CoV-2 proteins.
Lennart Koepke,Maximilian Hirschenberger,Manuel Hayn,Frank Kirchhoff,Konstantin M. J. Sparrer +4 more
TL;DR: In this paper, the impact of individual SARS-CoV-2 proteins on autophagy was analyzed and the molecular mechanisms of ORF3a and ORF7a were determined.
Journal ArticleDOI
Semen inhibits Zika virus infection of cells and tissues from the anogenital region
Janis A. Müller,Mirja Harms,Franziska Krüger,Rüdiger Groß,Simone Joas,Manuel Hayn,Andrea N Dietz,Sina Lippold,Jens von Einem,Axel Schubert,Manuela Michel,Benjamin Mayer,Mirko Cortese,Karen S. Jang,Nathallie Sandi-Monroy,Miriam Deniz,Florian Ebner,Olli Vapalahti,Markus Otto,Ralf Bartenschlager,Jean-Philippe Herbeuval,Jonas Schmidt-Chanasit,Nadia R. Roan,Jan Münch +23 more
TL;DR: Semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses and suggest that ZIKV transmission is limited by semen.