L
Linda Mustelin
Researcher at University of Helsinki
Publications - 5
Citations - 816
Linda Mustelin is an academic researcher from University of Helsinki. The author has contributed to research in topics: Young adult & FEV1/FVC ratio. The author has an hindex of 3, co-authored 5 publications receiving 786 citations. Previous affiliations of Linda Mustelin include Helsinki University Central Hospital.
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Journal ArticleDOI
Genome-wide association study identifies five loci associated with lung function.
Emmanouela Repapi,Ian Sayers,Louise V. Wain,Paul Burton,Toby Johnson,Ma'en Obeidat,Jing Hua Zhao,Adaikalavan Ramasamy,Guangju Zhai,Veronique Vitart,Jennifer E. Huffman,Wilmar Igl,E Albrecht,Panagiotis Deloukas,John Henderson,Raquel Granell,Wendy L. McArdle,Alicja R. Rudnicka,Inês Barroso,Loos Rjf.,Nicholas J. Wareham,Linda Mustelin,Taina Rantanen,Ida Surakka,Ida Surakka,Medea Imboden,H E Wichmann,Ivica Grković,Stipan Janković,Lina Zgaga,Hartikainen A-L.,Hartikainen A-L.,Hartikainen A-L.,Leena Peltonen,Leena Peltonen,Leena Peltonen,Ulf Gyllensten,Åsa Johansson,Ghazal Zaboli,Harry Campbell,Sarah H. Wild,James F. Wilson,Sven Gläser,Georg Homuth,Henry Völzke,Massimo Mangino,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Ozren Polasek,Igor Rudan,Igor Rudan,Alan F. Wright,Markku Heliövaara,Samuli Ripatti,Samuli Ripatti,Anneli Pouta,Åsa Torinsson Naluai,Olin A-C.,Kjell Torén,Mark E. Cooper,Alan James,Lyle J. Palmer,Lyle J. Palmer,Aroon D. Hingorani,S.G. Wannamethee,Peter H. Whincup,George Davey Smith,Shah Ebrahim,Tricia M. McKeever,Ian D. Pavord,Andrew K. MacLeod,Andrew D. Morris,David J. Porteous,Cyrus Cooper,Cyrus Cooper,Elaine M. Dennison,Seif O. Shaheen,Stefan Karrasch,E Schnabel,Holger Schulz,H Grallert,Nabila Bouatia-Naji,Jérôme Delplanque,Philippe Froguel,Philippe Froguel,John D Blakey,John Britton,Richard W Morris,John W. Holloway,Debbie A Lawlor,Jennie Hui,Jennie Hui,Fredrik Nyberg,Fredrik Nyberg,Jarvelin M-R.,Catherine Jackson,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Nicole Probst-Hensch,Nicole Probst-Hensch,Beate Koch,Caroline Hayward,David M. Evans,Paul Elliott,Paul Elliott,David P. Strachan,Ian P. Hall,Martin D. Tobin +109 more
TL;DR: Genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium offers mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
Journal ArticleDOI
Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins.
Linda Mustelin,Linda Mustelin,Karri Silventoinen,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Aila Rissanen,Jaakko Kaprio +6 more
TL;DR: Physically active subjects were leaner than sedentary ones, and physical activity reduced the influence of genetic factors to develop high BMI and WC, which suggests that the individuals at greatest genetic risk for obesity would benefit the most from physical activity.
Journal ArticleDOI
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity.
Linda Mustelin,Kirsi H. Pietiläinen,Aila Rissanen,Anssi Sovijärvi,Päivi Piirilä,Jussi Naukkarinen,Leena Peltonen,Jaakko Kaprio,Hannele Yki-Järvinen +8 more
TL;DR: The obese cotwins had lower insulin sensitivity than their nonobese counterparts and were also less fit, as measured by Vo(2max) and working capacity, which implies that acquired poor physical fitness is associated with defective expression of the oxidative pathway components in adipose tissue mitochondria.