M
Ma'en Obeidat
Researcher at University of British Columbia
Publications - 90
Citations - 5485
Ma'en Obeidat is an academic researcher from University of British Columbia. The author has contributed to research in topics: Genome-wide association study & COPD. The author has an hindex of 28, co-authored 85 publications receiving 4181 citations. Previous affiliations of Ma'en Obeidat include University of Nottingham & St. Paul's Hospital.
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Journal ArticleDOI
Genome-wide association study identifies five loci associated with lung function.
Emmanouela Repapi,Ian Sayers,Louise V. Wain,Paul Burton,Toby Johnson,Ma'en Obeidat,Jing Hua Zhao,Adaikalavan Ramasamy,Guangju Zhai,Veronique Vitart,Jennifer E. Huffman,Wilmar Igl,E Albrecht,Panagiotis Deloukas,John Henderson,Raquel Granell,Wendy L. McArdle,Alicja R. Rudnicka,Inês Barroso,Loos Rjf.,Nicholas J. Wareham,Linda Mustelin,Taina Rantanen,Ida Surakka,Ida Surakka,Medea Imboden,H E Wichmann,Ivica Grković,Stipan Janković,Lina Zgaga,Hartikainen A-L.,Hartikainen A-L.,Hartikainen A-L.,Leena Peltonen,Leena Peltonen,Leena Peltonen,Ulf Gyllensten,Åsa Johansson,Ghazal Zaboli,Harry Campbell,Sarah H. Wild,James F. Wilson,Sven Gläser,Georg Homuth,Henry Völzke,Massimo Mangino,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Ozren Polasek,Igor Rudan,Igor Rudan,Alan F. Wright,Markku Heliövaara,Samuli Ripatti,Samuli Ripatti,Anneli Pouta,Åsa Torinsson Naluai,Olin A-C.,Kjell Torén,Mark E. Cooper,Alan James,Lyle J. Palmer,Lyle J. Palmer,Aroon D. Hingorani,S.G. Wannamethee,Peter H. Whincup,George Davey Smith,Shah Ebrahim,Tricia M. McKeever,Ian D. Pavord,Andrew K. MacLeod,Andrew D. Morris,David J. Porteous,Cyrus Cooper,Cyrus Cooper,Elaine M. Dennison,Seif O. Shaheen,Stefan Karrasch,E Schnabel,Holger Schulz,H Grallert,Nabila Bouatia-Naji,Jérôme Delplanque,Philippe Froguel,Philippe Froguel,John D Blakey,John Britton,Richard W Morris,John W. Holloway,Debbie A Lawlor,Jennie Hui,Jennie Hui,Fredrik Nyberg,Fredrik Nyberg,Jarvelin M-R.,Catherine Jackson,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Nicole Probst-Hensch,Nicole Probst-Hensch,Beate Koch,Caroline Hayward,David M. Evans,Paul Elliott,Paul Elliott,David P. Strachan,Ian P. Hall,Martin D. Tobin +109 more
TL;DR: Genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium offers mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
Journal ArticleDOI
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James D. McKay,Rayjean J. Hung,Younghun Han,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Xiangjun Xiao,Yafang Li,Jinyoung Byun,Alison M. Dunning,Karen A. Pooley,David C. Qian,Xuemei Ji,Geoffrey Liu,Maria Timofeeva,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Xifeng Wu,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,Adonina Tardón,Gad Rennert,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Henricus F. M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Matt P Barnett,Chu Chen,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,H-Erich Wichmann,H-Erich Wichmann,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,Vladimir Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,Philippe Joubert,Maxime Lamontagne,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,Linda Kachuri,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Thorunn Rafnar,Thorgeir E. Thorgeirsson,Gunnar W Reginsson,Kari Stefansson,Dana B. Hancock,Laura J. Bierut,Margaret R. Spitz,Nathan C. Gaddis,Sharon M. Lutz,Fangyi Gu,Eric O. Johnson,Ahsan Kamal,Claudio W. Pikielny,Dakai Zhu,Sara Lindstroem,Xia Jiang,Rachel F. Tyndale,Rachel F. Tyndale,Georgia Chenevix-Trench,Jonathan Beesley,Yohan Bossé,Stephen J. Chanock,Paul Brennan,Maria Teresa Landi,Christopher I. Amos +146 more
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
Journal ArticleDOI
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
María Soler Artigas,Daan W. Loth,Louise V. Wain,Sina A. Gharib,Ma'en Obeidat,Wenbo Tang,Guangju Zhai,Guangju Zhai,Jing Hua Zhao,Albert V. Smith,Jennifer E. Huffman,Eva Albrecht,C.M. Jackson,David M. Evans,Gemma Cadby,Gemma Cadby,Myriam Fornage,Ani Manichaikul,Lorna M. Lopez,Toby Johnson,Melinda C. Aldrich,Thor Aspelund,Ins Barroso,Ins Barroso,Harry Campbell,Patricia A. Cassano,David Couper,Gudny Eiriksdottir,Nora Franceschini,Melissa E. Garcia,Christian Gieger,Gauti Kjartan Gislason,Ivica Grković,Christopher J Hammond,Dana B. Hancock,Dana B. Hancock,Tamara B. Harris,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Susan R. Heckbert,Susan R. Heckbert,Markku Heliövaara,Georg Homuth,Pirro G. Hysi,Alan James,Alan James,Stipan Janković,Bonnie R. Joubert,Stefan Karrasch,Norman Klopp,Beate Koch,Stephen B. Kritchevsky,Lenore J. Launer,Yongmei Liu,Laura R. Loehr,Kurt Lohman,Ruth J. F. Loos,Thomas Lumley,Khalid A. Al Balushi,Wei Ang,R. Graham Barr,John Beilby,John D Blakey,Mladen Boban,Vesna Boraska,Jonas Brisman,John Britton,Guy Brusselle,Cyrus Cooper,Ivan Curjuric,Santosh Dahgam,Ian J. Deary,Shah Ebrahim,Mark Eijgelsheim,Clyde Francks,Darya Gaysina,Raquel Granell,Xiangjun Gu,John L. Hankinson,Rebecca Hardy,Sarah E. Harris,John Henderson,Amanda P. Henry,Aroon D. Hingorani,Albert Hofman,Patrick G. Holt,Jennie Hui,Jennie Hui,Michael Hunter,Michael Hunter,Medea Imboden,Karen A. Jameson,Shona M. Kerr,Ivana Kolcic,Florian Kronenberg,Jason Z. Liu,Jonathan Marchini,Tricia M. McKeever,Andrew D. Morris,Anna-Carin Olin,David J. Porteous,Dirkje S. Postma,Stephen S. Rich,Susan M. Ring,Fernando Rivadeneira,Thierry Rochat,Avan Aihie Sayer,Ian Sayers,Peter D. Sly,George Davey Smith,Akshay Sood,John M. Starr,André G. Uitterlinden,Judith M. Vonk,S. Goya Wannamethee,Peter H. Whincup,Cisca Wijmenga,O. Dale Williams,Andrew Wong,Massimo Mangino,Kristin D. Marciante,Wendy L. McArdle,Bernd Meibohm,Alanna C. Morrison,Kari E. North,Ernst Omenaas,Lyle J. Palmer,Lyle J. Palmer,Kirsi H. Pietiläinen,Isabelle Pin,Ozren Polasek,Anneli Pouta,Bruce M. Psaty,Bruce M. Psaty,Anna-Liisa Hartikainen,Taina Rantanen,Samuli Ripatti,Samuli Ripatti,Jerome I. Rotter,Igor Rudan,Igor Rudan,Alicja R. Rudnicka,Holger Schulz,So-Youn Shin,Tim D. Spector,Ida Surakka,Ida Surakka,Veronique Vitart,Henry Völzke,Nicholas J. Wareham,Nicole M. Warrington,Nicole M. Warrington,H.-Erich Wichmann,Sarah H. Wild,Jemma B. Wilk,Matthias Wjst,Alan F. Wright,Lina Zgaga,Lina Zgaga,Tatijana Zemunik,Craig E. Pennell,Fredrik Nyberg,Fredrik Nyberg,Diana Kuh,John W. Holloway,H. Marike Boezen,Debbie A Lawlor,Richard W Morris,Nicole Probst-Hensch,Jaakko Kaprio,Jaakko Kaprio,James F. Wilson,Caroline Hayward,Mika Kähönen,Joachim Heinrich,Arthur W. Musk,Arthur W. Musk,Deborah Jarvis,Deborah Jarvis,Sven Gläser,Sven Gläser,Marjo-Riitta Järvelin,Bruno H. Ch. Stricker,Bruno H. Ch. Stricker,Paul Elliott,Paul Elliott,George T. O'Connor,George T. O'Connor,David P. Strachan,Stephanie J. London,Ian P. Hall,Vilmundur Gudnason,Martin D. Tobin +192 more
TL;DR: This article identified new regions showing association with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2.
Journal ArticleDOI
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
Louise V. Wain,Nick Shrine,Suzanne Miller,Victoria E. Jackson,Ioanna Ntalla,María Soler Artigas,Charlotte K. Billington,Abdul Kader Kheirallah,Richard J. Allen,J. P. Cook,Kelly Probert,Ma'en Obeidat,Yohan Bossé,Ke Hao,Ke Hao,Dirkje S. Postma,Peter D. Paré,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Reedik Mägi,Evelin Mihailov,Eva Reinmaa,Erik Melén,Jared O'Connell,Jared O'Connell,Eleni Frangou,Olivier Delaneau,Olivier Delaneau,Colin Freeman,Desislava Petkova,Mark I. McCarthy,Mark I. McCarthy,Ian Sayers,Panos Deloukas,Panos Deloukas,Richard Hubbard,Ian D. Pavord,Anna Hansell,Anna Hansell,Neil C. Thomson,Eleftheria Zeggini,Andrew P. Morris,Jonathan Marchini,Jonathan Marchini,David P. Strachan,Martin D. Tobin,Martin D. Tobin,Ian P. Hall +48 more
TL;DR: By sampling from the extremes of the lung function distribution in UK Biobank, novel genetic causes of lung function and smoking behaviour are identified and substantial shared genetic architecture underlying airflow obstruction is shown across individuals, irrespective of smoking behaviour and other airway disease.
Journal ArticleDOI
A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample
Ma'en Obeidat,Louise V. Wain,Nick Shrine,Noor Kalsheker,María Soler Artigas,Emmanouela Repapi,Emmanouela Repapi,Paul Burton,Toby Johnson,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Jing Hua Zhao,Guangju Zhai,Jennifer E. Huffman,Veronique Vitart,Eva Albrecht,Wilmar Igl,Anna-Liisa Hartikainen,Anneli Pouta,Gemma Cadby,Gemma Cadby,Jennie Hui,Jennie Hui,Lyle J. Palmer,Lyle J. Palmer,David Hadley,David Hadley,Wendy L. McArdle,Alicja R. Rudnicka,Inês Barroso,Inês Barroso,Ruth J. F. Loos,Nicholas J. Wareham,Massimo Mangino,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Sven Gläser,Georg Homuth,Henry Völzke,Panos Deloukas,Raquel Granell,John Henderson,Ivica Grković,Stipan Janković,Lina Zgaga,Ozren Polasek,Igor Rudan,Igor Rudan,Alan F. Wright,Harry Campbell,Sarah H. Wild,James F. Wilson,Joachim Heinrich,Medea Imboden,Nicole Probst-Hensch,Nicole Probst-Hensch,Ulf Gyllensten,Åsa Johansson,Ghazal Zaboli,Linda Mustelin,Taina Rantanen,Ida Surakka,Ida Surakka,Jaakko Kaprio,Jaakko Kaprio,Marjo-Riitta Järvelin,Caroline Hayward,David M. Evans,Beate Koch,Arthur W. Musk,Arthur W. Musk,Paul Elliott,David P. Strachan,Martin D. Tobin,Ian Sayers,Ian P. Hall +76 more
TL;DR: Polymorphisms spanning previously associated lung function genes did not show strong evidence for association with lung function measures in the SpiroMeta consortium population of 20,288 individuals from the general population.