L
Line Fraemohs
Researcher at RWTH Aachen University
Publications - 12
Citations - 1534
Line Fraemohs is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Cell adhesion molecule & Junctional Adhesion Molecule A. The author has an hindex of 12, co-authored 12 publications receiving 1422 citations. Previous affiliations of Line Fraemohs include University of Düsseldorf.
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Journal ArticleDOI
The role of junctional adhesion molecules in vascular inflammation.
TL;DR: This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology.
Journal ArticleDOI
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.
Eun-Young Choi,Emmanouil Chavakis,Marcus Czabanka,Harald F. Langer,Line Fraemohs,Matina Economopoulou,Ramendra K. Kundu,Alessia Orlandi,Ying Yi Zheng,DaRue A. Prieto,Christie M. Ballantyne,Stephanie L. Constant,William C. Aird,Thalia Papayannopoulou,Carl G. Gahmberg,Mark C. Udey,Peter Vajkoczy,Thomas Quertermous,Stefanie Dimmeler,Christian Weber,Triantafyllos Chavakis +20 more
TL;DR: Endothelial Del-1 (developmental endothelial locus–1) is described as an anti-adhesive factor that interferes with the integrin LFA-1–dependent leukocyte- endothelial adhesion and could provide a basis for targeting leukocytes-endothelial interactions in disease.
Journal ArticleDOI
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases
Rory R. Koenen,Jessica Pruessmeyer,Oliver Soehnlein,Line Fraemohs,Alma Zernecke,Nicole Schwarz,Karina Reiss,Alisina Sarabi,Lennart Lindbom,Tilman M. Hackeng,Christian Weber,Andreas Ludwig +11 more
TL;DR: In this article, the authors demonstrate that cultured endothelial cells not only express a cellular 43kDa variant of JAM-A but also release considerable amounts of a 33kDa soluble JAMA variant.
Journal ArticleDOI
CD73/Ecto-5′-Nucleotidase Protects Against Vascular Inflammation and Neointima Formation
Alma Zernecke,Kiril Bidzhekov,Burcin Özüyaman,Line Fraemohs,Elisa A. Liehn,Juliane Lüscher-Firzlaff,Bernhard Lüscher,Jürgen Schrader,Christian Weber +8 more
TL;DR: The data epitomize the importance of vascular CD73 in limiting endothelial activation and monocyte recruitment via generation of adenosine acting through the A2A receptor, providing a molecular basis for therapeutic protection against vascular inflammation and neointimal hyperplasia.
Journal ArticleDOI
Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial Infarction
Elisa A. Liehn,Nancy Tuchscheerer,Isabella Kanzler,Maik Drechsler,Maik Drechsler,Line Fraemohs,Alexander Schuh,Rory R. Koenen,Rory R. Koenen,Simone Zander,Oliver Soehnlein,Oliver Soehnlein,Mihail Hristov,Mihail Hristov,Gabriela Grigorescu,Andreea O. Urs,Mircea Leabu,Ilie Bucur,Marc W. Merx,Alma Zernecke,Josef Ehling,Felix Gremse,Twan Lammers,Fabian Kiessling,Juergen Bernhagen,Andreas Schober,Christian Weber,Christian Weber +27 more
TL;DR: CXCR4 plays a crucial role in endogenous remodeling processes after MI, contributing to inflammatory/progenitor cell recruitment and neovascularization, whereas its deficiency limits infarct size and causes adaptation to hypoxic stress.