Journal ArticleDOI
The role of junctional adhesion molecules in vascular inflammation.
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TLDR
This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology.Abstract:
Junctional adhesion molecules (JAMs) of the immunoglobulin superfamily are important in the control of vascular permeability and leukocyte transmigration across endothelial-cell surfaces, by engaging in homophilic, heterophilic and lateral interactions. Through their localization on the endothelial-cell surface and expression by platelets, JAMs contribute to adhesive interactions with circulating leukocytes and platelets. Antibody-blocking studies and studies using genetically modified mice have implicated these functions of JAMs in the regulation of leukocyte recruitment to sites of inflammation and ischaemia-reperfusion injury, in growth-factor-mediated angiogenesis, atherogenesis and neointima formation. The comparison of different JAM-family members and animal models, however, shows that the picture remains rather complex. This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology.read more
Citations
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Journal ArticleDOI
Blood-brain barrier tight junction permeability and ischemic stroke.
Karin E. Sandoval,Ken A. Witt +1 more
TL;DR: This review focuses on those aspects of ischemic stroke impacting BBB TJ integrity and the principle regulatory pathways, respective to the phases of paracellular permeability.
Journal ArticleDOI
Leukocyte migration into inflamed tissues.
Sussan Nourshargh,Ronen Alon +1 more
TL;DR: Current knowledge and open questions regarding the mechanisms involved in the interactions of different effector leukocytes with peripheral vessels in extralymphoid organs are discussed.
Journal ArticleDOI
The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications
Elisabetta Dejana,Elisabeth Tournier-Lasserve,Elisabeth Tournier-Lasserve,Brant M. Weinstein +3 more
TL;DR: This review discusses recent findings derived from basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish and their possible integration in a common picture of human pathologies.
Journal ArticleDOI
The blood-brain barrier in brain homeostasis and neurological diseases.
Nicolas Weiss,Florence Miller,Florence Miller,Sylvie Cazaubon,Sylvie Cazaubon,Pierre-Olivier Couraud,Pierre-Olivier Couraud +6 more
TL;DR: This review will focus on the implication of brain endothelial tight junctions in BBB architecture and physiology, will discuss the consequences of BBB dysfunction in these CNS diseases and will present some therapeutic strategies for drug delivery to the brain across the BBB.
Journal ArticleDOI
Regulation of endothelial junctional permeability.
TL;DR: The endothelium is a semi‐permeable barrier that regulates the flux of liquid and solutes, including plasma proteins, between the blood and surrounding tissue and the mechanisms that regulate paracellular permeability are provided.
References
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Journal ArticleDOI
Inflammation, Atherosclerosis, and Coronary Artery Disease
TL;DR: The evidence is recounted that atherosclerosis, the main cause of CAD, is an inflammatory disease in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial tree.
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Inflammation, atherosclerosis, and coronary artery disease.
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Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration
Ines Martin-Padura,Susan Lostaglio,Markus Schneemann,Lisa Williams,Maria Romano,Paolo Fruscella,Carla Panzeri,Antonella Stoppacciaro,Luigi Ruco,Antonello Villa,David Simmons,Elisabetta Dejana +11 more
TL;DR: JAM is a new component of endothelial and epithelial junctions that play a role in regulating monocyte transmigration and is identified as a novel immunoglobulin gene superfamily member that consists of two V-type Ig domains.
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Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
Yuqing Huo,Andreas Schober,S. Bradley Forlow,David F. Smith,Matthew C. Hyman,Steffen Jung,Dan R. Littman,Christian Weber,Klaus Ley +8 more
TL;DR: The results indicate that circulating activated platelets and platelet–leukocyte/monocyte aggregates promote formation of atherosclerotic lesions.
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Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
TL;DR: This Review introduces a new and unified nomenclature for the junctional adhesion molecule (JAM) family, which is probably involved in regulating the signaling as well as the adhesion events of diapedesis.