L
Linsey Reavie
Researcher at New York University
Publications - 11
Citations - 2563
Linsey Reavie is an academic researcher from New York University. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 9, co-authored 11 publications receiving 2272 citations. Previous affiliations of Linsey Reavie include European Institute of Oncology & Howard Hughes Medical Institute.
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Journal ArticleDOI
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Kelly Moran-Crusio,Linsey Reavie,Alan Shih,Omar Abdel-Wahab,Delphine Ndiaye-Lobry,Camille Lobry,Maria E. Figueroa,Aparna Vasanthakumar,Jay P. Patel,Xinyang Zhao,Fabiana Perna,Suveg Pandey,Jozef Madzo,Chun-Xiao Song,Qing Dai,Chuan He,Sherif Ibrahim,Miloslav Beran,Jiri Zavadil,Stephen D. Nimer,Stephen D. Nimer,Ari Melnick,Lucy A. Godley,Iannis Aifantis,Ross L. Levine +24 more
TL;DR: An animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by competitive transplant assays is reported.
Journal ArticleDOI
Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor
Miguel F. Segura,Douglas Hanniford,Silvia Menendez,Linsey Reavie,Xuanyi Zou,Silvia Alvarez-Diaz,Jan Zakrzewski,Elen Blochin,Amy Rose,Dusan Bogunovic,David Polsky,Jian-Jun Wei,Peng Lee,Ilana Belitskaya-Levy,Nina Bhardwaj,Iman Osman,Eva Hernando +16 more
TL;DR: This work finds that miR-182, member of a miRNA cluster in a chromosomal locus frequently amplified in melanoma, is commonly up-regulated in human melanoma cell lines and tissue samples and suggests that miRNA silencing may be a worthwhile therapeutic strategy.
Journal ArticleDOI
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.
Bryan King,Thomas Trimarchi,Linsey Reavie,Linsey Reavie,Luyao Xu,Jasper Mullenders,Panagiotis Ntziachristos,Beatriz Aranda-Orgilles,Arianne Perez-Garcia,Junwei Shi,Christopher R. Vakoc,Peter Sandy,Steven S. Shen,Steven S. Shen,Adolfo A. Ferrando,Iannis Aifantis,Iannis Aifantis +16 more
TL;DR: It is demonstrated that small-molecule-mediated suppression of MYC activity leads to T-ALL remission, suggesting an effective therapeutic strategy.
Journal ArticleDOI
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
Silvia Buonamici,Thomas Trimarchi,Maria Grazia Ruocco,Linsey Reavie,Séverine Cathelin,Brenton G. Mar,Apostolos Klinakis,Yevgeniy Lukyanov,Jen-Chieh Tseng,Filiz Sen,Eric A. Gehrie,Mengling Li,Elizabeth W. Newcomb,Jiri Zavadil,Daniel Meruelo,Martin Lipp,Sherif Ibrahim,Argiris Efstratiadis,David Zagzag,Jonathan S. Bromberg,Michael L. Dustin,Iannis Aifantis +21 more
TL;DR: It is shown that the chemokine receptor CCR7 is the essential adhesion signal required for the targeting of leukaemic T-cells into the CNS and targeted inhibition of CNS involvement in T-ALL could potentially decrease the intensity of CNS-targeted therapy, thus reducing its associated short- and long-term complications.
Journal ArticleDOI
The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation
TL;DR: This review will focus on one member of the UPS, the F-box protein, Fbw7 (also known as Sel-10, Ago, hCDC4) and mechanisms by which FbW7 interacts with its substrates in the context of development and tumorigenesis will be discussed.