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Suveg Pandey
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 11
Citations - 2421
Suveg Pandey is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Myeloid & Leukemia. The author has an hindex of 8, co-authored 11 publications receiving 2058 citations. Previous affiliations of Suveg Pandey include Cornell University.
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Journal ArticleDOI
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Kelly Moran-Crusio,Linsey Reavie,Alan Shih,Omar Abdel-Wahab,Delphine Ndiaye-Lobry,Camille Lobry,Maria E. Figueroa,Aparna Vasanthakumar,Jay P. Patel,Xinyang Zhao,Fabiana Perna,Suveg Pandey,Jozef Madzo,Chun-Xiao Song,Qing Dai,Chuan He,Sherif Ibrahim,Miloslav Beran,Jiri Zavadil,Stephen D. Nimer,Stephen D. Nimer,Ari Melnick,Lucy A. Godley,Iannis Aifantis,Ross L. Levine +24 more
TL;DR: An animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by competitive transplant assays is reported.
Journal ArticleDOI
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Omar Abdel-Wahab,Mazhar Adli,Lindsay M. LaFave,Jie Gao,Todd Hricik,Alan H. Shih,Suveg Pandey,Jay P. Patel,Young Rock Chung,Richard Koche,Fabiana Perna,Xinyang Zhao,Jordan E. Taylor,Christopher Y. Park,Martin Carroll,Ari Melnick,Stephen D. Nimer,Jacob D. Jaffe,Iannis Aifantis,Bradley E. Bernstein,Ross L. Levine,Ross L. Levine +21 more
TL;DR: It is identified that ASXL1 mutations result in loss of polycomb repressive complex 2 (PRC2)-mediated histone H3 lysine 27 (H3K27) tri-methylation, and that loss of AS XL1 in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.
Journal ArticleDOI
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
Omar Abdel-Wahab,Jie Gao,Mazhar Adli,Anwesha Dey,Thomas Trimarchi,Young Rock Chung,Cem Kuscu,Todd Hricik,Delphine Ndiaye-Lobry,Lindsay M. LaFave,Richard Koche,Richard Koche,Alan H. Shih,Olga A. Guryanova,Eunhee Kim,Sheng Li,Suveg Pandey,Joseph Y. Shin,Leon Telis,Jinfeng Liu,Parva K. Bhatt,Sebastien Monette,Xinyang Zhao,Christopher E. Mason,Christopher Y. Park,Bradley E. Bernstein,Bradley E. Bernstein,Iannis Aifantis,Ross L. Levine,Ross L. Levine +29 more
TL;DR: Loss of Asxl1 results in myelodysplastic syndrome, whereas concomitant deletion of Tet2 restores HSC self-renewal and triggers a more severe disease phenotype distinct from that seen in single-gene knockout mice.
Journal ArticleDOI
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms
Raajit K. Rampal,Jihae Ahn,Omar Abdel-Wahab,Michelle Nahas,Kai Wang,Doron Lipson,Geoff Otto,Roman Yelensky,Todd Hricik,Anna Sophia McKenney,Gabriela Chiosis,Young Rock Chung,Suveg Pandey,Marcel R.M. van den Brink,Scott A. Armstrong,Ahmet Dogan,Andrew M. Intlekofer,Taghi Manshouri,Christopher Y. Park,Srdan Verstovsek,Franck Rapaport,Philip J. Stephens,Vincent A. Miller,Ross L. Levine +23 more
TL;DR: In vitro studies revealed that post-MPN AML cells were sensitive to decitabine, the JAK1/2 inhibitor ruxolitinib, or the heat shock protein 90 inhibitor 8-(6-iodobenzo-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purine-6-amine (PU-H71).
Journal ArticleDOI
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
Alan H. Shih,Yanwen Jiang,Cem Meydan,Kaitlyn Shank,Suveg Pandey,Laura Barreyro,Iléana Antony-Debré,Agnes Viale,Nicholas D. Socci,Yongming Sun,Alexander Robertson,Magali Cavatore,Elisa de Stanchina,Todd Hricik,Franck Rapaport,Brittany Woods,Chen Wei,Megan A. Hatlen,Muhamed Baljevic,Stephen D. Nimer,Martin S. Tallman,Elisabeth Paietta,Luisa Cimmino,Iannis Aifantis,Ulrich Steidl,Christopher E. Mason,Ari Melnick,Ross L. Levine +27 more
TL;DR: Mice generated with mutations in Tet2 and Flt3 resulted in fully penetrant, lethal AML, with a defined leukemia stem cell population characterized by site-specific changes in DNA methylation and gene expression.