L
Liusheng Huang
Researcher at University of California, San Francisco
Publications - 54
Citations - 1396
Liusheng Huang is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Dihydroartemisinin & Lumefantrine. The author has an hindex of 20, co-authored 54 publications receiving 1239 citations. Previous affiliations of Liusheng Huang include Karolinska Institutet & University of Iowa.
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Journal ArticleDOI
Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data
Elizabeth A. Ashley,Francesca T. Aweeka,Karen I. Barnes,Quique Bassat,Steffen Borrmann,Steffen Borrmann,Prabin Dahal,Prabin Dahal,Tme Davis,Philippe Deloron,Mey Bouth Denis,Abdoulaye Djimde,Jean-François Faucher,Blaise Genton,Blaise Genton,Philippe J Guerin,Kamal Hamed,Eva Maria Hodel,Eva Maria Hodel,Liusheng Huang,Jullien,Harin Karunajeewa,Harin Karunajeewa,Kiechel,Poul-Erik Kofoed,Gilbert Lefèvre,Niklas Lindegardh,Kevin Marsh,Kevin Marsh,Andreas Mårtensson,Mayfong Mayxay,Mayfong Mayxay,Rose McGready,C Moreira,Paul N. Newton,Billy Ngasala,François Nosten,Christian Nsanzabana,Christian Nsanzabana,Sunil Parikh,Ric N. Price,Pascal Ringwald,Lars Rombo,Lars Rombo,Birgit Schramm,Carol Hopkins Sibley,Kasia Stepniewska,Johan Ursing,Michèle van Vugt,Michèle van Vugt,Nicholas J. White,Lesley Workman +51 more
TL;DR: Higher, more frequent, or prolonged dosage regimens should now be evaluated in very young children, particularly if malnourished, and in patients with hyperparasitemia, as well as patients in very low transmission intensity areas with emerging parasite resistance.
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Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial
Victor Bigira,James Kapisi,Tamara D. Clark,Stephen Kinara,Florence Mwangwa,Mary K. Muhindo,Beth Osterbauer,Francesca T. Aweeka,Liusheng Huang,Jane Achan,Diane V. Havlir,Philip J. Rosenthal,Moses R. Kamya,Grant Dorsey +13 more
TL;DR: The efficacy of three antimalarial drugs for preventing malaria in children living in Uganda, an area of high transmission intensity, is investigated.
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Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers.
Liusheng Huang,Sunil Parikh,Philip J. Rosenthal,Patricia Lizak,Florence Marzan,Grant Dorsey,Diane V. Havlir,Francesca T. Aweeka +7 more
TL;DR: Exposure to DHA, but not LR, was significantly lower during EFV-AL co-administration compared with that during administration of AL alone, and these findings may have implications for the treatment efficacy of AL, particularly in children.
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Role of heme-protein covalent bonds in mammalian peroxidases. Protection of the heme by a single engineered heme-protein link in horseradish peroxidase
TL;DR: It is unambiguously demonstrated that a single heme-protein link is sufficient to protect the heme from vinyl group modification even in a protein (HRP) that is normally highly susceptible to this reaction.
Journal ArticleDOI
In vitro metabolism of piperaquine is primarily mediated by CYP3A4.
Tina Ming-Na Lee,Liusheng Huang,Marla K. Johnson,Patricia Lizak,Deanna L. Kroetz,Francesca T. Aweeka,Sunil Parikh +6 more
TL;DR: The extent of inhibition of in vitro metabolism with ketoconazole (83%) denotes that PQ appears to be primarily catalyzed by CYP3A4, and further studies to support these findings through the identification and characterization of PQ metabolites are planned.