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Elaine H. Shen
Researcher at Allen Institute for Brain Science
Publications - 5
Citations - 3874
Elaine H. Shen is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Gene expression profiling & Neocortex. The author has an hindex of 5, co-authored 5 publications receiving 3078 citations.
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Journal ArticleDOI
An anatomically comprehensive atlas of the adult human brain transcriptome
Michael Hawrylycz,Ed S. Lein,Angela L. Guillozet-Bongaarts,Elaine H. Shen,Lydia Ng,Jeremy A. Miller,Louie N. van de Lagemaat,Kimberly A. Smith,Amanda Ebbert,Zackery L. Riley,Chris Abajian,Christian F. Beckmann,Amy Bernard,Darren Bertagnolli,Andrew F. Boe,Preston M. Cartagena,M. Mallar Chakravarty,Mike Chapin,Jimmy Chong,Rachel A. Dalley,Barry Daly,Chinh Dang,Suvro Datta,Nick Dee,Tim A. Dolbeare,Vance Faber,David Feng,David R. Fowler,Jeff Goldy,Benjamin W. Gregor,Zeb Haradon,David R. Haynor,John G. Hohmann,Steve Horvath,Robert Howard,Andreas Jeromin,Jayson M. Jochim,Marty Kinnunen,Christopher Lau,Evan T. Lazarz,Changkyu Lee,Tracy Lemon,Ling Li,Yang Li,John A. Morris,Caroline C. Overly,Patrick D. Parker,Sheana Parry,Melissa Reding,Joshua J. Royall,Jay Schulkin,Pedro Adolfo Sequeira,Clifford R. Slaughterbeck,Simon Smith,Andy J. Sodt,Susan M. Sunkin,Beryl Swanson,Marquis P. Vawter,Derric Williams,Paul Wohnoutka,H. Ronald Zielke,Daniel H. Geschwind,Patrick R. Hof,Stephen M. Smith,Christof Koch,Seth G. N. Grant,Allan R. Jones +66 more
TL;DR: A transcriptional atlas of the adult human brain is described, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals, to form a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.
Journal ArticleDOI
Transcriptional landscape of the prenatal human brain
Jeremy A. Miller,Songlin Ding,Susan M. Sunkin,Kimberly A. Smith,Lydia Ng,Aaron Szafer,Amanda Ebbert,Zackery L. Riley,Joshua J. Royall,Kaylynn Aiona,James M. Arnold,Crissa Bennet,Darren Bertagnolli,Krissy Brouner,Stephanie Butler,Shiella Caldejon,Anita Carey,Christine Cuhaciyan,Rachel A. Dalley,Nick Dee,Tim A. Dolbeare,Benjamin A.C. Facer,David Feng,Tim P. Fliss,Garrett Gee,Jeff Goldy,Lindsey Gourley,Benjamin W. Gregor,Guangyu Gu,Robert Howard,Jayson M. Jochim,Chihchau L. Kuan,Christopher Lau,Changkyu Lee,Felix Lee,Tracy Lemon,Phil Lesnar,Bergen McMurray,Naveed Mastan,Nerick Mosqueda,Theresa Naluai-Cecchini,Nhan Kiet Ngo,Julie Nyhus,Aaron Oldre,Eric Olson,Jody Parente,Patrick D. Parker,Sheana Parry,Allison Stevens,Mihovil Pletikos,Melissa Reding,Kate Roll,David Sandman,Melaine Sarreal,Sheila Shapouri,Nadiya V. Shapovalova,Elaine H. Shen,Nathan Sjoquist,Clifford R. Slaughterbeck,Michael W. Smith,Andy J. Sodt,Derric Williams,Lilla Zöllei,Bruce Fischl,Mark Gerstein,Daniel H. Geschwind,Ian A. Glass,Michael Hawrylycz,Robert F. Hevner,Hao Huang,Allan R. Jones,James A. Knowles,Pat Levitt,John W. Phillips,Nenad Sestan,Paul Wohnoutka,Chinh Dang,Amy Bernard,John G. Hohmann,Ed S. Lein +79 more
TL;DR: An anatomically comprehensive atlas of the mid-gestational human brain is described, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions.
Journal ArticleDOI
Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures
Hongkui Zeng,Elaine H. Shen,John G. Hohmann,Seung Wook Oh,Amy Bernard,Joshua J. Royall,Katie J. Glattfelder,Susan M. Sunkin,John A. Morris,Angela L. Guillozet-Bongaarts,Kimberly A. Smith,Amanda Ebbert,Beryl Swanson,Leonard Kuan,Damon T. Page,Caroline C. Overly,Ed S. Lein,Michael Hawrylycz,Patrick R. Hof,Thomas M. Hyde,Thomas M. Hyde,Joel E. Kleinman,Allan R. Jones +22 more
TL;DR: The data suggest that gene expression profile changes may contribute to differential cortical function across species, and in particular, a shift from corticosubcortical to more predominant corticocortical communications in the human brain.
Journal ArticleDOI
The Allen Human Brain Atlas: comprehensive gene expression mapping of the human brain
TL;DR: The Allen Human Brain Atlas is a freely available multimodal atlas of gene expression and anatomy comprising a comprehensive 'all genes-all structures' array-based dataset of geneexpression and complementary in situ hybridization gene expression studies targeting selected genes in specific brain regions.
Journal ArticleDOI
Improving reliability and absolute quantification of human brain microarray data by filtering and scaling probes using RNA-Seq
Jeremy A. Miller,Vilas Menon,Jeff Goldy,Ajamete Kaykas,Changkyu Lee,Kimberly A. Smith,Elaine H. Shen,John W. Phillips,Ed S. Lein,Michael Hawrylycz +9 more
TL;DR: It is shown that RNA-Seq can be used as ground truth to assess the reliability of most microarray probes, remove probes with off-target effects, and scale probe intensities to match the expression levels identified by RNA- Seq.