L
Lucie McCoy
Researcher at University of California, San Francisco
Publications - 47
Citations - 3842
Lucie McCoy is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Glioma & Genome-wide association study. The author has an hindex of 24, co-authored 42 publications receiving 3127 citations. Previous affiliations of Lucie McCoy include University of California.
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Journal ArticleDOI
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
Jeanette E. Eckel-Passow,Daniel H. Lachance,Annette M. Molinaro,Kyle M. Walsh,Paul A. Decker,Hugues Sicotte,Melike Pekmezci,Terri Rice,Matt L. Kosel,Ivan Smirnov,Gobinda Sarkar,Alissa Caron,Thomas M. Kollmeyer,Corinne Praska,Anisha R. Chada,Chandralekha Halder,Helen M. Hansen,Lucie McCoy,Paige M. Bracci,Roxanne Marshall,Shichun Zheng,Gerald F. Reis,Alexander R. Pico,Brian P. O'Neill,Jan C. Buckner,Caterina Giannini,Jason T. Huse,Arie Perry,Tarik Tihan,Mitchell S. Berger,Susan M. Chang,Michael D. Prados,Joseph L. Wiemels,John K. Wiencke,Margaret Wrensch,Robert B. Jenkins +35 more
TL;DR: The five glioma molecular groups had different ages at onset, overall survival, and associations with germline variants, which implies that they are characterized by distinct mechanisms of pathogenesis.
Journal ArticleDOI
Variants in the CDKN2B and RTEL1 regions are associated with high grade glioma susceptibility
Margaret Wrensch,Robert B. Jenkins,Jeffrey S. Chang,Ru Fang Yeh,Yuanyuan Xiao,Paul A. Decker,Karla V. Ballman,Mitchel S. Berger,Jan C. Buckner,Susan M. Chang,Caterina Giannini,Chandralekha Halder,Thomas M. Kollmeyer,Matthew L. Kosel,Daniel H. Lachance,Lucie McCoy,Brian P. O'Neill,Joe Patoka,Alexander R. Pico,Michael D. Prados,Charles P. Quesenberry,Terri Rice,Amanda L. Rynearson,Ivan Smirnov,Tarik Tihan,Joseph L. Wiemels,Ping Yang,John K. Wiencke +27 more
TL;DR: A principal component–adjusted genome-wide association study of 275,895 autosomal variants among 692 adult high-grade glioma cases and 3,992 controls found that two SNPs had the same direction of association in discovery and replication phases.
Journal ArticleDOI
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
Beatrice Melin,Jill S. Barnholtz-Sloan,Margaret Wrensch,Christoffer Johansen,Dora Il'yasova,Dora Il'yasova,Ben Kinnersley,Quinn T. Ostrom,Karim Labreche,Karim Labreche,Yanwen Chen,Georgina Armstrong,Yanhong Liu,Jeanette E. Eckel-Passow,Paul A. Decker,Marianne Labussière,Ahmed Idbaih,Khê Hoang-Xuan,Anna Luisa Di Stefano,Karima Mokhtari,Jean-Yves Delattre,Peter Broderick,Pilar Galan,Konstantinos Gousias,Johannes Schramm,Minouk J. Schoemaker,Sarah Fleming,Stefan Herms,Stefanie Heilmann,Markus M. Nöthen,Heinz-Erich Wichmann,Heinz-Erich Wichmann,Stefan Schreiber,Anthony J. Swerdlow,Anthony J. Swerdlow,Mark Lathrop,Matthias Simon,Marc Sanson,Ulrika Andersson,Preetha Rajaraman,Stephen J. Chanock,Martha S. Linet,Zhaoming Wang,Meredith Yeager,John K. Wiencke,Helen M. Hansen,Lucie McCoy,Terri Rice,Matthew L. Kosel,Hugues Sicotte,Christopher I. Amos,Jonine L. Bernstein,Faith G. Davis,Dan Lachance,Ching C. Lau,Ryan Merrell,Joellen Shildkraut,Francis Ali-Osman,Siegal Sadetzki,Siegal Sadetzki,Michael E. Scheurer,Sanjay Shete,Rose Lai,Elizabeth B. Claus,Elizabeth B. Claus,Sara H. Olson,Robert B. Jenkins,Richard S. Houlston,Melissa L. Bondy +68 more
TL;DR: A meta-analysis of existing GWAS and two new GWAS substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
Journal ArticleDOI
Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.
Melike Pekmezci,Terri Rice,Annette M. Molinaro,Kyle M. Walsh,Paul A. Decker,Helen M. Hansen,Hugues Sicotte,Thomas M. Kollmeyer,Lucie McCoy,Gobinda Sarkar,Arie Perry,Caterina Giannini,Tarik Tihan,Mitchel S. Berger,Joseph L. Wiemels,Paige M. Bracci,Jeanette E. Eckel-Passow,Daniel H. Lachance,Jennifer Leigh Clarke,Jennie Taylor,Tracy Luks,John K. Wiencke,Robert B. Jenkins,Margaret Wrensch +23 more
TL;DR: Evidence is presented that in certain WHO 2016 diagnostic groups, testing for TERT promoter mutations or ATRX alterations may provide additional useful prognostic information.
Journal ArticleDOI
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk
Kyle M. Walsh,Veryan Codd,Ivan Smirnov,Terri Rice,Paul A. Decker,Helen M. Hansen,Thomas M. Kollmeyer,Matthew L. Kosel,Annette M. Molinaro,Lucie McCoy,Paige M. Bracci,Belinda S. Cabriga,Melike Pekmezci,Shichun Zheng,Joseph L. Wiemels,Alexander R. Pico,Tarik Tihan,Mitchell S. Berger,Susan M. Chang,Michael D. Prados,Daniel H. Lachance,Brian P. O'Neill,Hugues Sicotte,Jeanette E. Eckel-Passow,Pim van der Harst,John K. Wiencke,Nilesh J. Samani,Robert B. Jenkins,Margaret Wrensch +28 more
TL;DR: This paper identified a new SNP associated with glioma risk, rs1920116 (near TERC), that reached genome-wide significance (Pcombined = 8.3 × 10(-9)) in a meta-analysis of genomewide association studies.