M
Mark Lathrop
Researcher at McGill University
Publications - 8
Citations - 2121
Mark Lathrop is an academic researcher from McGill University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 7, co-authored 8 publications receiving 1982 citations. Previous affiliations of Mark Lathrop include Council on Education for Public Health & Boston University.
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Journal ArticleDOI
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.
Valentina Escott-Price,Céline Bellenguez,Li-San Wang,Seung Hoan Choi,Denise Harold,Lesley Jones,Peter Holmans,Amy Gerrish,Alexey Vedernikov,Alexander Richards,Anita L. DeStefano,Jean-Charles Lambert,Carla A. Ibrahim-Verbaas,Adam C. Naj,Rebecca Sims,Gyungah Jun,Joshua C. Bis,Gary W. Beecham,Benjamin Grenier-Boley,Giancarlo Russo,Tricia A. Thornton-Wells,Nicola Denning,Albert V. Smith,Vincent Chouraki,Charlene Thomas,M. Arfan Ikram,Diana Zelenika,Badri N. Vardarajan,Badri N. Vardarajan,Yoichiro Kamatani,Chiao-Feng Lin,Helena Schmidt,Brian W. Kunkle,Melanie L. Dunstan,Maria Vronskaya,Andrew D. Johnson,Agustín Ruiz,Marie-Thérèse Bihoreau,Christiane Reitz,Florence Pasquier,Paul Hollingworth,Olivier Hanon,Annette L. Fitzpatrick,Joseph D. Buxbaum,Dominique Campion,Paul K. Crane,Clinton T. Baldwin,Tim Becker,Vilmundur Gudnason,Carlos Cruchaga,David Craig,Najaf Amin,Claudine Berr,Oscar L. Lopez,Philip L. De Jager,Philip L. De Jager,Vincent Deramecourt,Janet A. Johnston,Denis A. Evans,Simon Lovestone,Luc Letenneur,Isabel Hernández,David C. Rubinsztein,Gudny Eiriksdottir,Kristel Sleegers,Alison Goate,Nathalie Fievet,Matthew J. Huentelman,Michael Gill,Kristelle Brown,M. Ilyas Kamboh,Lina Keller,Pascale Barberger-Gateau,Bernadette McGuinness,Eric B. Larson,Eric B. Larson,Amanda J. Myers,Carole Dufouil,Stephen Todd,David Wallon,Seth Love,Ekaterina Rogaeva,John Gallacher,Peter St George-Hyslop,Jordi Clarimón,Alberto Lleó,Antony James Bayer,Debby W. Tsuang,Lei Yu,Magda Tsolaki,Paola Bossù,Gianfranco Spalletta,Petra Proitsi,John Collinge,Sandro Sorbi,Florentino Sanchez Garcia,Nick C. Fox,John Hardy,Maria Candida Deniz Naranjo,Paolo Bosco,Robert Clarke,Carol Brayne,Daniela Galimberti,Elio Scarpini,Ubaldo Bonuccelli,Michelangelo Mancuso,Gabriele Siciliano,Susanne Moebus,Patrizia Mecocci,Maria Del Zompo,Wolfgang Maier,Harald Hampel,Alberto Pilotto,Ana Frank-García,Francesco Panza,Vincenzo Solfrizzi,Paolo Caffarra,Benedetta Nacmias,William Perry,Manuel Mayhaus,Lars Lannfelt,Hakon Hakonarson,Sabrina Pichler,Minerva M. Carrasquillo,Martin Ingelsson,Duane Beekly,Victoria Alvarez,Fanggeng Zou,Otto Valladares,Steven G. Younkin,Eliecer Coto,Kara L. Hamilton-Nelson,Wei Gu,Cristina Razquin,Pau Pastor,Ignacio Mateo,Michael John Owen,Kelley Faber,Palmi V. Jonsson,Onofre Combarros,Michael Conlon O'Donovan,Laura B. Cantwell,Hilkka Soininen,Deborah Blacker,Simon Mead,Thomas H. Mosley,David A. Bennett,Tamara B. Harris,Laura Fratiglioni,Laura Fratiglioni,Clive Holmes,Renée F.A.G. de Bruijn,Peter Passmore,Thomas J. Montine,Karolien Bettens,Jerome I. Rotter,Alexis Brice,Kevin Morgan,Tatiana Foroud,Walter A. Kukull,Didier Hannequin,John Powell,Mike A. Nalls,Karen Ritchie,Kathryn L. Lunetta,John S. K. Kauwe,Eric Boerwinkle,Matthias Riemenschneider,Mercè Boada,Mikko Hiltunen,Eden R. Martin,Reinhold Schmidt,Dan Rujescu,Jean-François Dartigues,Richard Mayeux,Christophe Tzourio,Albert Hofman,Markus M. Nöthen,Caroline Graff,Bruce M. Psaty,Bruce M. Psaty,Jonathan L. Haines,Jonathan L. Haines,Mark Lathrop,Margaret A. Pericak-Vance,Lenore J. Launer,Christine Van Broeckhoven,Lindsay A. Farrer,Cornelia M. van Duijn,Alfredo Ramirez,Sudha Seshadri,Sudha Seshadri,Gerard D. Schellenberg,Philippe Amouyel,Julie Williams +194 more
TL;DR: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimers disease.
Journal ArticleDOI
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
Beatrice Melin,Jill S. Barnholtz-Sloan,Margaret Wrensch,Christoffer Johansen,Dora Il'yasova,Dora Il'yasova,Ben Kinnersley,Quinn T. Ostrom,Karim Labreche,Karim Labreche,Yanwen Chen,Georgina Armstrong,Yanhong Liu,Jeanette E. Eckel-Passow,Paul A. Decker,Marianne Labussière,Ahmed Idbaih,Khê Hoang-Xuan,Anna Luisa Di Stefano,Karima Mokhtari,Jean-Yves Delattre,Peter Broderick,Pilar Galan,Konstantinos Gousias,Johannes Schramm,Minouk J. Schoemaker,Sarah Fleming,Stefan Herms,Stefanie Heilmann,Markus M. Nöthen,Heinz-Erich Wichmann,Heinz-Erich Wichmann,Stefan Schreiber,Anthony J. Swerdlow,Anthony J. Swerdlow,Mark Lathrop,Matthias Simon,Marc Sanson,Ulrika Andersson,Preetha Rajaraman,Stephen J. Chanock,Martha S. Linet,Zhaoming Wang,Meredith Yeager,John K. Wiencke,Helen M. Hansen,Lucie McCoy,Terri Rice,Matthew L. Kosel,Hugues Sicotte,Christopher I. Amos,Jonine L. Bernstein,Faith G. Davis,Dan Lachance,Ching C. Lau,Ryan Merrell,Joellen Shildkraut,Francis Ali-Osman,Siegal Sadetzki,Siegal Sadetzki,Michael E. Scheurer,Sanjay Shete,Rose Lai,Elizabeth B. Claus,Elizabeth B. Claus,Sara H. Olson,Robert B. Jenkins,Richard S. Houlston,Melissa L. Bondy +68 more
TL;DR: A meta-analysis of existing GWAS and two new GWAS substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for glioma
Ben Kinnersley,Marianne Labussière,Amy Holroyd,Anna Luisa Di Stefano,Peter Broderick,Jayaram Vijayakrishnan,Karima Mokhtari,Jean-Yves Delattre,Konstantinos Gousias,Johannes Schramm,Minouk J. Schoemaker,Sarah Fleming,Stefan Herms,Stefan Herms,Stefanie Heilmann,Stefan Schreiber,Heinz-Erich Wichmann,Markus M. Nöthen,Anthony J. Swerdlow,Mark Lathrop,Mark Lathrop,Matthias Simon,Melissa L. Bondy,Marc Sanson,Richard S. Houlston +24 more
TL;DR: The authors' findings provide further insights into the genetic basis of the different glioma subtypes, and identify new risk loci for glioblastoma and non-GBM at 12q23.2 and 15q24.2, respectively.
Journal ArticleDOI
Unifying candidate gene and GWAS approaches in asthma.
Sven Michel,Liming Liang,Martin Depner,Norman Klopp,Andreas Ruether,Ashok Kumar,Michaela Schedel,Christian Vogelberg,Erika von Mutius,Andrea von Berg,Albrecht Bufe,Ernst Rietschel,Andrea Heinzmann,Otto Laub,Burkhard Simma,Thomas Frischer,Jon Genuneit,Ivo Gut,Stefan Schreiber,Mark Lathrop,Thomas Illig,Michael Kabesch +21 more
TL;DR: GWAS coverage is insufficient for many asthma candidate genes, imputation based on these data is reliable but incomplete, and SNPs in three previously identified asthma candidate gene genes replicate in the authors' GWAS population with significance after correction for multiple testing in 14 genes.
Journal ArticleDOI
Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Yu-Ching Cheng,Yu-Ching Cheng,Tara M. Stanne,Anne-Katrin Giese,Weang Kee Ho,Matthew Traylor,Philippe Amouyel,Elizabeth G. Holliday,Rainer Malik,Huichun Xu,Steven J. Kittner,Steven J. Kittner,John W. Cole,John W. Cole,Jeffrey R. O'Connell,John Danesh,John Danesh,Asif Rasheed,Wei Zhao,Stefan T. Engelter,Caspar Grond-Ginsbach,Yoichiro Kamatani,Mark Lathrop,Didier Leys,Vincent Thijs,Vincent Thijs,Tiina M. Metso,Turgut Tatlisumak,Alessandro Pezzini,Eugenio Parati,Bo Norrving,Steve Bevan,Peter M. Rothwell,Cathie Sudlow,Agnieszka Slowik,Arne Lindgren,Matthew Walters,Jim Jannes,Jess Shen,David R. Crosslin,Kimberly F. Doheny,Cathy C. Laurie,Sandip M. Kanse,Joshua C. Bis,Myriam Fornage,Thomas H. Mosley,Jemma C. Hopewell,Konstantin Strauch,Martina Müller-Nurasyid,Christian Gieger,Melanie Waldenberger,Annette Peters,Christine Meisinger,M. Arfan Ikram,W. T. Longstreth,James F. Meschia,Sudha Seshadri,Pankaj Sharma,Bradford B. Worrall,Christina Jern,Christopher R Levi,Martin Dichgans,Giorgio B. Boncoraglio,Hugh S. Markus,Stéphanie Debette,Stéphanie Debette,Stéphanie Debette,Arndt Rolfs,Danish Saleheen,Danish Saleheen,Braxton D. Mitchell,Braxton D. Mitchell +71 more
TL;DR: A 2-stage meta-analysis of genome-wide association studies on stroke cases with an age of onset <60 years found that HABP2, which encodes an extracellular serine protease involved in coagulation, fibrinolysis, and inflammatory pathways, may be a genetic susceptibility locus for early-onset stroke.