L
Ludwig A. Hothorn
Researcher at Leibniz University of Hanover
Publications - 193
Citations - 4413
Ludwig A. Hothorn is an academic researcher from Leibniz University of Hanover. The author has contributed to research in topics: Sample size determination & Confidence interval. The author has an hindex of 27, co-authored 181 publications receiving 3792 citations. Previous affiliations of Ludwig A. Hothorn include Roche Diagnostics & University of California, San Francisco.
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Journal ArticleDOI
Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease
Heribert Schunkert,Anika Götz,Peter S. Braund,Ralph McGinnis,David-Alexandre Trégouët,Massimo Mangino,Patrick Linsel-Nitschke,François Cambien,Christian Hengstenberg,Klaus Stark,Stefan Blankenberg,Laurence Tiret,Pierre Ducimetière,Andrew Keniry,Mohammed J. R. Ghori,Stefan Schreiber,Nour Eddine El Mokhtari,Alistair S. Hall,Richard J. Dixon,Alison H. Goodall,Henrike Liptau,Helen Pollard,Daniel F Schwarz,Ludwig A. Hothorn,H.-Erich Wichmann,Inke R. König,Marcus Fischer,Christa Meisinger,Willem H. Ouwehand,Panos Deloukas,John R. Thompson,Jeanette Erdmann,Andreas Ziegler,Nilesh J. Samani +33 more
TL;DR: A broad replication provides unprecedented evidence for association between genetic variants at chromosome 9p21.3 and risk of coronary artery disease (CAD).
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Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections
Gabriela Senti,Reto Crameri,Daniela Kuster,Pål Johansen,Julia M. Martinez-Gomez,Nicole Graf,Martin Dr. Steiner,Ludwig A. Hothorn,Hans Grönlund,Christine Tivig,Anna Zaleska,Ozge Soyer,Marianne van Hage,Cezmi A. Akdis,Mübeccel Akdis,H. Rose,Thomas M. Kündig +16 more
TL;DR: In a first-in-human clinical study ILIT with MAT-Fel d 1 was safe and induced allergen tolerance after 3 injections, and was also positively correlated with IL-10 production.
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nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals
TL;DR: A new R package nparcomp is introduced which provides an easy and user-friendly access to rank-based methods for the analysis of unbalanced one-way layouts and provides procedures performing multiple comparisons and computing simultaneous confidence intervals for the estimated effects which can be easily visualized.
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Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
Anne K. Krug,Raivo Kolde,John Antonydas Gaspar,Eugen Rempel,Nina V. Balmer,Kesavan Meganathan,Kinga Vojnits,Mathurin Baquié,Tanja Waldmann,Roberto Ensenat-Waser,Smita Jagtap,Richard Evans,Stéphanie Julien,Hedi Peterson,Dimitra Zagoura,Suzanne Kadereit,Daniel Gerhard,Isaia Sotiriadou,Michael Heke,Karthick Natarajan,Margit Henry,Johannes Winkler,Rosemarie Marchan,Luc Stoppini,Sieto Bosgra,Joost Westerhout,Miriam Verwei,Jaak Vilo,Andreas Kortenkamp,Jürgen Hescheler,Ludwig A. Hothorn,Susanne Bremer,Christoph van Thriel,Karl-Heinz Krause,Jan G. Hengstler,Jörg Rahnenführer,Marcel Leist,Agapios Sachinidis +37 more
TL;DR: The ESNATS assay battery allows classification of human DNT/RT toxicants on the basis of their transcriptome profiles and a relatively large ‘common response’ to VPA and MeHg could be distinguished from ‘compound-specific’ responses.
Journal ArticleDOI
Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission.
Julia Santiago,Benjamin Brandt,Mari Wildhagen,Ulrich Hohmann,Ludwig A. Hothorn,Melinka A. Butenko,Michael Hothorn +6 more
TL;DR: It is shown that IDA is sensed directly by the HAESA ectodomain, suggesting that plant peptide hormone receptors may share a common ligand binding mode and activation mechanism.