L
Luis Navarro Sanchez
Researcher at University of Glasgow
Publications - 3
Citations - 2813
Luis Navarro Sanchez is an academic researcher from University of Glasgow. The author has contributed to research in topics: Wnt signaling pathway & DNA methylation. The author has an hindex of 3, co-authored 3 publications receiving 2001 citations.
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Journal ArticleDOI
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey,David K. Chang,Katia Nones,Katia Nones,Amber L. Johns,Ann-Marie Patch,Ann-Marie Patch,Marie-Claude Gingras,David Miller,David Miller,Angelika N. Christ,Timothy J. C. Bruxner,Michael C.J. Quinn,Michael C.J. Quinn,Craig Nourse,Craig Nourse,Murtaugh Lc,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Ehsan Nourbakhsh,Shivangi Wani,Shivangi Wani,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Chin,Matthew J. Anderson,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Nicola Waddell,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Peter J. Wilson,Nicole Cloonan,Nicole Cloonan,Karin S. Kassahn,Karin S. Kassahn,Karin S. Kassahn,Darrin Taylor,Kelly Quek,Alan J. Robertson,Lorena Pantano,Laura Mincarelli,Luis Navarro Sanchez,Lisa Evers,Jianmin Wu,Mark Pinese,Mark J. Cowley,Jones,Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Jeremy L. Humphris,Angela Chou,Angela Chou,Marina Pajic,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Kim Moran-Jones,Nigel B. Jamieson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Karin A. Oien,Hair J,Robert Grützmann,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Corbo,Claudio Bassi,Borislav Rusev,Paola Capelli,Roberto Salvia,Giampaolo Tortora,Debabrata Mukhopadhyay,Gloria M. Petersen,Munzy Dm,William E. Fisher,Saadia A. Karim,Eshleman,Ralph H. Hruban,Christian Pilarsky,Jennifer P. Morton,Owen J. Sansom,Aldo Scarpa,Elizabeth A. Musgrove,Ulla-Maja Bailey,Oliver Hofmann,Oliver Hofmann,R. L. Sutherland,David A. Wheeler,Anthony J. Gill,Anthony J. Gill,Richard A. Gibbs,John V. Pearson,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond,Sean M. Grimmond +128 more
TL;DR: Detailed genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing.
Journal ArticleDOI
Copy number signatures and mutational processes in ovarian carcinoma
Geoff Macintyre,Teodora Goranova,D.G.H. de Silva,Darren Ennis,Anna M. Piskorz,Matthew D. Eldridge,Daoud Sie,Liz Anne Lewsley,Aishah Hanif,Cheryl Wilson,Suzanne Dowson,Rosalind Glasspool,Michelle Lockley,Michelle Lockley,Elly Brockbank,Ana Montes,Axel Walther,Sudha Sundar,Richard J. Edmondson,Richard J. Edmondson,Geoff Hall,Andrew R Clamp,Charlie Gourley,Marcia Hall,Christina Fotopoulou,Hani Gabra,Hani Gabra,James Paul,Anna Supernat,David Millan,Aoisha Hoyle,Gareth Bryson,Craig Nourse,Laura Mincarelli,Luis Navarro Sanchez,Bauke Ylstra,Mercedes Jimenez-Linan,Luiza Moore,Oliver Hofmann,Oliver Hofmann,Florian Markowetz,Iain A. McNeish,Iain A. McNeish,Iain A. McNeish,James D. Brenton +44 more
TL;DR: It is shown that HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in known patterns of genomic aberration, and copy number signature exposures at diagnosis predict both overall survival and the probability of platinum-resistant relapse.
Posted ContentDOI
Copy-number signatures and mutational processes in ovarian carcinoma
Geoff Macintyre,Teodora Goranova,D.G.H. de Silva,Darren Ennis,Anna M. Piskorz,Matthew D. Eldridge,Daoud Sie,Liz Anne Lewsley,Aishah Hanif,Cheryl Wilson,Suzanne Dowson,Rosalind Glasspool,Michelle Lockley,Elly Brockbank,Ana Montes,Axel Walther,Sudha Sundar,Richard J. Edmondson,Geoff Hall,Andrew R Clamp,Charlie Gourley,Marcia Hall,Christina Fotopoulou,Hani Gabra,James Paul,Anna Supernat,David Millan,Aoisha Hoyle,Gareth Bryson,Craig Nourse,Laura Mincarelli,Luis Navarro Sanchez,Bauke Ylstra,Mercedes Jimenez-Linan,Luiza Moore,Oliver Hofmann,Florian Markowetz,Iain A. McNeish,James D. Brenton +38 more
TL;DR: It is demonstrated that most tumours are heterogeneous and harbour multiple signature exposures, and changes in signature exposure observed in response to chemotherapy suggest potential treatment strategies.