L
Lynda Misher
Researcher at Seattle Biomed
Publications - 10
Citations - 313
Lynda Misher is an academic researcher from Seattle Biomed. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 9, co-authored 9 publications receiving 307 citations. Previous affiliations of Lynda Misher include Novartis.
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Journal ArticleDOI
Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Partially Mimics the In Vivo Development of Neutralizing Antibodies
Delphine C. Malherbe,Nicole A. Doria-Rose,Lynda Misher,Travis Beckett,Travis Beckett,Wendy B. Puryear,Wendy B. Puryear,Wendy B. Puryear,Jason T. Schuman,Zane Kraft,Jean P. O'Malley,Motomi Mori,Indresh K. Srivastava,Indresh K. Srivastava,Susan W. Barnett,Leonidas Stamatatos,Leonidas Stamatatos,Nancy L. Haigwood,Nancy L. Haigwood +18 more
TL;DR: This study is the first to explore the use of a collection of HIV-1 env quasispecies variants as immunogens and to present evidence that it is possible to educate the B-cell response by sequential exposure to native HIV-2 env variants derived from an individual with a broadened NAb response.
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Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSA
Marion Avril,Bridget R. Kulasekara,Severin Gose,Christopher G. Rowe,Madeleine Dahlbäck,Patrick E. Duffy,Michal Fried,Ali Salanti,Lynda Misher,David L. Narum,Joseph D. Smith,Joseph D. Smith +11 more
TL;DR: It is demonstrated that VAR2CSA contains common polymorphic epitopes that are shared between geographically diverse CSA-binding lines, which is a leading candidate for a pregnancy malaria vaccine.
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Inactivated whole SIV vaccine in macaques: evaluation of protective efficacy against challenge with cell-free virus or infected cells.
Philip R. Johnson,Philip R. Johnson,David C. Montefiori,Simon Goldstein,Tiffany E. Hamm,Tiffany E. Hamm,Jiying Zhou,Svetlana Kitov,Nancy L. Haigwood,Lynda Misher,William T. London,John L. Gerin,Anthony C. Allison,Robert H. Purcell,Robert M. Chanock,Vanessa M. Hirsch +15 more
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Evidence for persistent, occult infection in neonatal macaques following perinatal transmission of simian-human immunodeficiency virus SF162P3.
Pushpa Jayaraman,Tuofu Zhu,Lynda Misher,Deepika Mohan,La Rene Kuller,Patricia Polacino,Barbra A. Richardson,Helle Bielefeldt-Ohmann,David Anderson,Shiu Lok Hu,Nancy L. Haigwood +10 more
TL;DR: A high incidence of seropositive virus-low or -negative SHIV infection in infant macaques has implications for HIV type 1 perinatal transmission and detection.
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Mutations in Envelope gp120 Can Impact Proteolytic Processing of the gp160 Precursor and Thereby Affect Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Pseudoviruses
Wendy M. Blay,Theresa Kasprzyk,Lynda Misher,Barbra A. Richardson,Nancy L. Haigwood,Nancy L. Haigwood +5 more
TL;DR: Evidence is presented to suggest that minor mutations in gp120 can significantly impact Env processing and thereby mediate escape from a range of neutralizing agents.