M
M. Albert Basson
Researcher at King's College London
Publications - 74
Citations - 6974
M. Albert Basson is an academic researcher from King's College London. The author has contributed to research in topics: Cerebellum & Receptor tyrosine kinase. The author has an hindex of 33, co-authored 71 publications receiving 6180 citations. Previous affiliations of M. Albert Basson include National Institute for Medical Research & University of California, San Francisco.
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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum,Carina Gross,Jan Fiedler,Thomas Fischer,Stephan Kissler,Markus Bussen,Paolo Galuppo,Steffen Just,Wolfgang Rottbauer,Stefan Frantz,Mirco Castoldi,Jürgen Soutschek,Victor Koteliansky,Andreas Rosenwald,M. Albert Basson,Jonathan D. Licht,John T. R. Pena,Sara H. Rouhanifard,Martina U. Muckenthaler,Thomas Tuschl,Gail R. Martin,Johann Bauersachs,Stefan Engelhardt,Stefan Engelhardt +23 more
TL;DR: It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
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The aged niche disrupts muscle stem cell quiescence
TL;DR: It is demonstrated that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under homeostatic conditions, driving a subset of satellite cells to break quiescence and lose their self-renewing capacity.
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Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
TL;DR: New biochemical and genetic evidence indicates specific roles of the Spry genes in development and multiple modes of action of theSpry proteins in regulation of the RTK-induced response.
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Sprouty1 Is a Critical Regulator of GDNF/RET-Mediated Kidney Induction
M. Albert Basson,M. Albert Basson,Simge Akbulut,Judy Watson-Johnson,Ruth Simon,Thomas L. Carroll,Reena Shakya,Isabelle Gross,Gail R. Martin,Thomas Lufkin,Andrew P. McMahon,Patricia D. Wilson,Frank Costantini,Ivor Mason,Jonathan D. Licht +14 more
TL;DR: The function of Spry1 is to modulate GDNF/RET signaling in the Wolffian duct, ensuring that kidney induction is restricted to a single site and demonstrating the importance of negative feedback regulation of RTK signaling during kidney induction.
Journal ArticleDOI
Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration
Kelly L. Shea,Wanyi Xiang,Vincent S. LaPorta,Jonathan D. Licht,Charles Keller,M. Albert Basson,Andrew S. Brack +6 more
TL;DR: It is demonstrated that Sprouty1 (Spry1), an inhibitor of receptor tyrosine kinase signaling, is robustly expressed in quiescent Pax7+ satellite cells in uninjured adult muscle, down-regulated in proliferating myogenic cells in injured muscles, and re-induced as Pax 7+ cells return to quiescence in regenerated muscles.