M
Madison E. Weirick
Researcher at University of Pennsylvania
Publications - 39
Citations - 5113
Madison E. Weirick is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Antibody & Immune system. The author has an hindex of 18, co-authored 34 publications receiving 2002 citations.
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Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
Elizabeth M. Anderson,Eileen C. Goodwin,Anurag Verma,Claudia P. Arevalo,Marcus J. Bolton,Madison E. Weirick,Sigrid Gouma,Christopher M McAllister,Shannon R. Christensen,JoEllen Weaver,Phillip Hicks,Tomaz B. Manzoni,Oluwatosin Oniyide,Holly Ramage,Holly Ramage,Divij Mathew,Amy E. Baxter,Derek A. Oldridge,Allison R. Greenplate,Jennifer E. Wu,Cécile Alanio,Kurt D'Andrea,Oliva Kuthuru,Jeanette Dougherty,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sokratis A. Apostolidis,Alexander C. Huang,Laura A. Vella,Laura A. Vella,E. John Wherry,Nuala J. Meyer,Sara Cherry,Paul Bates,Daniel J. Rader,Scott E. Hensley +36 more
TL;DR: These studies indicate that most individuals possessed hCoV-reactive antibodies before the COVID-19 pandemic, and that ~23% of these individuals possessed non-neutralizing antibodies that cross-reacted with SARS- CoV-2 spike and nucleocapsid proteins.
Journal ArticleDOI
SARS-CoV-2 seroprevalence among parturient women in Philadelphia.
Dustin D. Flannery,Dustin D. Flannery,Sigrid Gouma,Miren B. Dhudasia,Sagori Mukhopadhyay,Sagori Mukhopadhyay,Madeline R. Pfeifer,Emily C. Woodford,Jeffrey S. Gerber,Jeffrey S. Gerber,Claudia P. Arevalo,Marcus J. Bolton,Madison E. Weirick,Eileen C. Goodwin,Elizabeth M. Anderson,Allison R. Greenplate,Justin Kim,Nicholas Han,Ajinkya Pattekar,Jeanette Dougherty,Oliva Kuthuru,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,JoEllen Weaver,Anurag Verma,Rita Leite,Jeffrey S. Morris,Daniel J. Rader,Michal A. Elovitz,E. John Wherry,Karen M. Puopolo,Karen M. Puopolo,Scott E. Hensley +34 more
TL;DR: Serological tests among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community and race/ethnicity differences in seroprevalence rates.
Posted ContentDOI
Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
Divij Mathew,Josephine R. Giles,Amy E. Baxter,Allison R. Greenplate,Jennifer E. Wu,Cécile Alanio,Derek A. Oldridge,Leticia Kuri-Cervantes,M. Betina Pampena,Sasikanth Manne,Zeyu Chen,Yinghui Jane Huang,John P. Reilly,Ariel R. Weisman,Caroline A. G. Ittner,Oliva Kuthuru,Jeanette Dougherty,Kito Nzingha,Nicholas Han,Justin Kim,Ajinkya Pattekar,Eileen C. Goodwin,Elizabeth M. Anderson,Madison E. Weirick,Sigrid Gouma,Claudia P. Arevalo,Marcus J. Bolton,Fang Chen,Simone F Lacey,Scott E. Hensley,Sokratis A. Apostolidis,Alexander C. Huang,Michael R. Betts,Nuala J. Meyer,E. John Wherry +34 more
TL;DR: Three “immunotypes” associated with poor clinical trajectories versus improving health are identified and may have implications for therapeutics and vaccines.
Journal ArticleDOI
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Katlyn Lederer,Emily Bettini,Kalpana Parvathaneni,Mark M. Painter,Divyansh Agarwal,Kendall A. Lundgreen,Madison E. Weirick,Kavitha Muralidharan,Diana Castaño,Rishi R. Goel,Xiaoming Xu,E. M. Drapeau,Sigrid Gouma,Jordan T. Ort,M. Awofolaju,Allison R. Greenplate,Carole Le Coz,Neil Romberg,Jennifer Trofe-Clark,Gregory Malat,Lisa Jones,Marc Rosen,Daniela Weiskopf,Alessandro Sette,Behdad Besharatian,M. Kamińiski,Scott E. Hensley,Paul Bates,E. John Wherry,Ali Naji,Vijay Bhoj,Michela Locci +31 more
TL;DR: In this paper , the immune responses to SARS-CoV-2 mRNA vaccines in lymph nodes of healthy individuals and kidney transplant recipients (KTXs) were analyzed through a fine-needle aspiration-based approach.
Posted ContentDOI
Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19
Laura A. Vella,Laura A. Vella,Josephine R. Giles,Amy E. Baxter,Derek A. Oldridge,Derek A. Oldridge,Caroline Diorio,Leticia Kuri-Cervantes,Cécile Alanio,Maria Betina Pampena,Jennifer E. Wu,Zeyu Chen,Yinghui Jane Huang,Elizabeth M. Anderson,Sigrid Gouma,Kevin O McNerney,Julie Chase,Chakkapong Burudpakdee,Jessica H. Lee,Sokratis A. Apostolidis,Alexander C. Huang,Divij Mathew,Oliva Kuthuru,Eileen C. Goodwin,Madison E. Weirick,Marcus J. Bolton,Claudia P. Arevalo,Andre Ramos,Cristina Jasen,Heather M. Giannini,Kurt D'Andrea,Nuala J. Meyer,Edward M. Behrens,Edward M. Behrens,Hamid Bassiri,Hamid Bassiri,Scott E. Hensley,Sarah E. Henrickson,Sarah E. Henrickson,David T. Teachey,Michael R. Betts,E. John Wherry +41 more
TL;DR: Non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and implicate CD8 T cells in clinical presentation and trajectory of MIS- C.