M
Madison E. Weirick
Researcher at University of Pennsylvania
Publications - 39
Citations - 5113
Madison E. Weirick is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Antibody & Immune system. The author has an hindex of 18, co-authored 34 publications receiving 2002 citations.
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Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
Rishi R. Goel,Mark M. Painter,Kendall A. Lundgreen,Sokratis A. Apostolidis,Amy E. Baxter,Josephine R. Giles,Divij Mathew,Ajinkya Pattekar,Arnold Reynaldi,David S. Khoury,Sigrid Gouma,Philip Hicks,Sarah Dysinger,Amanda Hicks,H. Sharma,Sarah Herring,Scott Korte,Wumesh Kc,Derek A. Oldridge,Rachel Erickson,Madison E. Weirick,Christopher M McAllister,M. Awofolaju,Nicole Tanenbaum,Jeanette Dougherty,S. Long,Kurt D'Andrea,J. Hamilton,Maura McLaughlin,Justine C. Williams,Sharon Adamski,Oliva Kuthuru,E. M. Drapeau,Miles P. Davenport,Scott E. Hensley,Paul Bates,Allison R. Greenplate,E. John Wherry +37 more
TL;DR: Examination of antibody and memory B cell responses in a cohort of individuals sampled longitudinally for ∼9-10 months after the primary 2-dose mRNA vaccine series suggests that high levels of circulating antibodies may limit reactivation of immunological memory and constrain further antibody boosting by mRNA vaccines.
Posted ContentDOI
mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern
Rishi R. Goel,Mark M Painter,Sokratis A. Apostolidis,Divij Mathew,Wenzhao Meng,Aaron M. Rosenfeld,Kendall A. Lundgreen,Arnold Reynaldi,David S. Khoury,Ajinkya Pattekar,Sigrid Gouma,Leticia Kuri-Cervantes,Philip Hicks,Sarah Dysinger,Amanda Hicks,Harsh Sharma,Sarah Herring,Scott Korte,Amy E. Baxter,Derek A. Oldridge,Josephine R. Giles,Madison E. Weirick,Christopher M McAllister,Moses Awofolaju,Nicole Tanenbaum,Elizabeth M Drapeau,Jeanette Dougherty,Sherea Long,Jacob T. Hamilton,Maura McLaughlin,Justine C. Williams,Sharon Adamski,Oliva Kuthuru,Ian Frank,Michael R. Betts,Alba Grifoni,Daniela Weiskopf,Alessandro Sette,Scott E. Hensley,Miles P. Davenport,Paul Bates,Eline T. Luning Prak,Allison R. Greenplate,E. John Wherry +43 more
TL;DR: In this article, the authors longitudinally profiled both antibody and cellular immune responses in SARS-CoV-2 naive and recovered individuals from pre-vaccine baseline to 6 months post-mRNA vaccination.
Posted ContentDOI
Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Olivia Kuthuru,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,Nuala J. Meyer,Michael R. Betts +29 more
TL;DR: Broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation are demonstrated.
Journal ArticleDOI
Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19).
Elizabeth M. Anderson,Caroline Diorio,Eileen C. Goodwin,Kevin O McNerney,Madison E. Weirick,Sigrid Gouma,Marcus J. Bolton,Claudia P. Arevalo,Julie Chase,Philip Hicks,Tomaz B. Manzoni,Amy E. Baxter,Kurt P Andrea,Chakkapong Burudpakdee,Jessica H. Lee,Laura A. Vella,Laura A. Vella,Sarah E. Henrickson,Rebecca M. Harris,E. John Wherry,Paul Bates,Hamid Bassiri,Edward M. Behrens,David T. Teachey,Scott E. Hensley +24 more
TL;DR: It is shown that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients.
Posted ContentDOI
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Katlyn Lederer,Kalpana Parvathaneni,Mark M Painter,Emily Bettini,Divyansh Agarwal,Kendall A. Lundgreen,Madison E. Weirick,Rishi R. Goel,Xiaoming Xu,Elizabeth M Drapeau,Sigrid Gouma,Allison R. Greenplate,Carole Le Coz,Carole Le Coz,Neil Romberg,Neil Romberg,Lisa Jones,Mark A. Rosen,Behdad Besharatian,Mary Kaminiski,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Scott E. Hensley,Paul Bates,E. John Wherry,Ali Naji,Vijay Bhoj,Michela Locci +28 more
TL;DR: In this paper, the immune responses to SARS-CoV-2 mRNA vaccines in lymph nodes of healthy individuals and kidney transplant (KTX) recipients were profiled through a fine-needle-aspiration-based approach.