Rex E. FitzGerald

TL;DR: Systems Toxicology approaches offer modern strategies for gaining mechanistic knowledge by combining advanced analytical and computational tools, and integrates current knowledge regarding bioanalytical approaches, computational analysis, and the potential for improved risk assessment.

TL;DR: Recommendations on a road map towards AOP-based DNT testing is considered a stepwise approach, operating initially with incomplete AOPs for compound grouping, and focussing on key events of neurodevelopment.

TL;DR: Suggestions are made on how DNT NAMs may be assembled into an integrated approach to testing and assessment (IATA), and a vision is presented on how further NAM development may be guided by knowledge of signaling pathways necessary for brain development, DNT pathophysiology, and relevant adverse outcome pathways (AOP).

TL;DR: The limitations and opportunities of selected emerging applications in this rapidly advancing field are described, including the use of large-scale data streams derived from omics measurements that require computational means for obtaining informative results.

TL;DR: In this article, an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by the Panel to be reliable, including data obtained with TiO2 nanoparticles (NPs) and data from an extended one-generation reproductive toxicity (EOGRT) study was presented.