Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells
Bethany D. Freedman,Bethany D. Freedman,Petra Bukovac Kempna,Petra Bukovac Kempna,Diana L. Carlone,Diana L. Carlone,Manasvi S. Shah,Manasvi S. Shah,Nick A. Guagliardo,Paula Q. Barrett,Celso E. Gomez-Sanchez,Joseph A. Majzoub,Joseph A. Majzoub,David T. Breault,David T. Breault +14 more
TLDR
It is demonstrated that adrenocortical zonation and regeneration result from lineage conversion and may provide a paradigm for homeostatic cellular renewal in other tissues.About:
This article is published in Developmental Cell.The article was published on 2013-09-30 and is currently open access. It has received 142 citations till now. The article focuses on the topics: Zona fasciculata & Adrenal cortex.read more
Citations
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Adult cell plasticity in vivo : de-differentiation and transdifferentiation are back in style
TL;DR: This work has demonstrated that certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as part of an organ's normal injury response.
Journal ArticleDOI
Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands
Koshiro Nishimoto,Scott A. Tomlins,Rork Kuick,Andi K. Cani,Thomas J. Giordano,Daniel H. Hovelson,Chia Jen Liu,Aalok R. Sanjanwala,Michael A. Edwards,Celso E. Gomez-Sanchez,Kazutaka Nanba,William E. Rainey +11 more
TL;DR: The APCC transcriptome is characterized and it is shown that CYP11B2 expression is increased compared with the rest of the adrenal cortex and that many APCCs harbor known aldosterone-producing adenoma (APA)-related ion channels/pumps that stimulate CYP12A2 expression and ald testosterone production.
Journal ArticleDOI
Plasticity within stem cell hierarchies in mammalian epithelia.
TL;DR: Recent examples of plasticity within an individual tissue stem cell hierarchy may be much more common than previously appreciated, highlighting the different modes of regeneration and their implications for the understanding of cellular hierarchy and tissue self-renewal.
Journal ArticleDOI
Development of Adrenal Cortex Zonation
TL;DR: The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocortioids, and adrenal androgens, respectively.
Journal ArticleDOI
Primary Aldosteronism and ARMC5 Variants
Mihail Zilbermint,Paraskevi Xekouki,Fabio R. Faucz,Annabel Berthon,Alexandra Gkourogianni,Marie Helene Schernthaner-Reiter,Maria Batsis,Ninet Sinaii,Martha Quezado,Maria J. Merino,Aaron Hodes,Smita Baid Abraham,Rossella Libé,Guillaume Assié,Stéphanie Espiard,Ludivine Drougat,Bruno Ragazzon,Adam Davis,Samson Y. Gebreab,Ryan Neff,Electron Kebebew,Jérôme Bertherat,Maya Lodish,Constantine A. Stratakis +23 more
TL;DR: Further cohorts of patients with primary aldosteronism and metabolic syndrome, particularly African Americans, should be screened for ARMC5 sequence variants because these may underlie part of the known increased predisposition of African Americans to low renin hypertension.
References
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TL;DR: In this article, a transgenic model of diphtheria-toxin-induced acute selective near-total beta-cell ablation was used to investigate whether adult mammals can differentiate (regenerate) new beta-cells after extreme, total β-cell loss, as in diabetes.
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