C
Cecilia M Lopez
Researcher at University of Florida
Publications - 7
Citations - 2719
Cecilia M Lopez is an academic researcher from University of Florida. The author has contributed to research in topics: Gene & Phenotype. The author has an hindex of 7, co-authored 7 publications receiving 2436 citations. Previous affiliations of Cecilia M Lopez include Medical University of South Carolina.
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Journal ArticleDOI
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok Junhee Seok,Shaw Warren,G. Cuenca Alex,N. Mindrinos Michael,V. Baker Henry,Weihong Xu,Daniel R. Richards,Grace P. McDonald-Smith,Hong Gao,Laura Hennessy,Celeste C. Finnerty,Cecilia M Lopez,Shari Honari,Ernest E. Moore,Joseph P. Minei,Joseph Cuschieri,Paul E. Bankey,Jeffrey L. Johnson,Jason L. Sperry,Avery B. Nathens,Timothy R. Billiar,Michael West,Marc G. Jeschke,Matthew B. Klein,Richard L. Gamelli,Nicole S. Gibran,Bernard H. Brownstein,Carol L. Miller-Graziano,Steve E. Calvano,Philip H. Mason,J. Perren Cobb,Laurence G. Rahme,Stephen F. Lowry,Ronald V. Maier,Lyle L. Moldawer,David N. Herndon,Ronald W. Davis,Wenzhong Xiao,Wenzhong Xiao,Ronald G. Tompkins +39 more
TL;DR: This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.
Journal ArticleDOI
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
Erin Vanzant,Cecilia M Lopez,Tezcan Ozrazgat-Baslanti,Ricardo Ungaro,Ruth Davis,Alex G. Cuenca,Lori F. Gentile,Dina C. Nacionales,Angela L. Cuenca,Azra Bihorac,Christiaan Leeuwenburgh,Jennifer Lanz,Henry V. Baker,Bruce A. McKinley,Lyle L. Moldawer,Frederick A. Moore,Philip A. Efron +16 more
TL;DR: Genomic analysis of patients with complicated clinical outcomes exhibit persistent genomic expression changes consistent with defects in the adaptive immune response and increased inflammation, which supports the hypothesis that patients withcomplicated clinical outcomes are exhibiting PICS.
Journal ArticleDOI
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Erin Vanzant,Rachael Hilton,Cecilia M Lopez,Jianyi Zhang,Ricardo Ungaro,Lori F. Gentile,Benjamin E. Szpila,Ronald V. Maier,Joseph Cuschieri,Azra Bihorac,Christiaan Leeuwenburgh,Frederick A. Moore,Henry V. Baker,Lyle L. Moldawer,Scott C. Brakenridge,Philip A. Efron +15 more
TL;DR: It is concluded that advanced age is one of the strongest non-injury related risk factors for poor outcomes after severe trauma with hemorrhagic shock and is associated with an altered and unique peripheral leukocyte genomic response.
Journal ArticleDOI
Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line.
Isabel Virella-Lowell,John-David Herlihy,Barry Liu,Cecilia M Lopez,Pedro E. Cruz,Chris Muller,Henry V. Baker,Terence R. Flotte +7 more
TL;DR: The CFTR genotype changes the expression of multiple genes at baseline and in response to bacterial challenge, and only a subset of these changes is secondary to IL-10 deficiency.
Journal ArticleDOI
Detection of altered extracellular matrix in surface layers of unstable carotid plaque: an optical spectroscopy, birefringence and microarray genetic analysis.
Renee M. Korol,Renee M. Korol,Peter B. Canham,Li Liu,Kasinath Viswanathan,Gary G. Ferguson,Robert Hammond,Helen M. Finlay,Henry V. Baker,Cecilia M Lopez,Alexandra Lucas +10 more
TL;DR: LIFS analysis coupled with microscopy revealed marked regional differences in collagen I, III and elastin in surface layers of carotid plaque; indicative of plaque instability.