S
Shaw Warren
Researcher at Harvard University
Publications - 6
Citations - 3479
Shaw Warren is an academic researcher from Harvard University. The author has contributed to research in topics: Vascular permeability & Regulation of gene expression. The author has an hindex of 4, co-authored 6 publications receiving 3083 citations.
Papers
More filters
Journal ArticleDOI
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok Junhee Seok,Shaw Warren,G. Cuenca Alex,N. Mindrinos Michael,V. Baker Henry,Weihong Xu,Daniel R. Richards,Grace P. McDonald-Smith,Hong Gao,Laura Hennessy,Celeste C. Finnerty,Cecilia M Lopez,Shari Honari,Ernest E. Moore,Joseph P. Minei,Joseph Cuschieri,Paul E. Bankey,Jeffrey L. Johnson,Jason L. Sperry,Avery B. Nathens,Timothy R. Billiar,Michael West,Marc G. Jeschke,Matthew B. Klein,Richard L. Gamelli,Nicole S. Gibran,Bernard H. Brownstein,Carol L. Miller-Graziano,Steve E. Calvano,Philip H. Mason,J. Perren Cobb,Laurence G. Rahme,Stephen F. Lowry,Ronald V. Maier,Lyle L. Moldawer,David N. Herndon,Ronald W. Davis,Wenzhong Xiao,Wenzhong Xiao,Ronald G. Tompkins +39 more
TL;DR: This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.
Journal ArticleDOI
A genomic storm in critically injured humans
Wenzhong Xiao,Wenzhong Xiao,Michael N. Mindrinos,Junhee Seok,Joseph Cuschieri,Alex G. Cuenca,Hong Gao,Douglas L. Hayden,Laura Hennessy,Ernest E. Moore,Joseph P. Minei,Paul E. Bankey,Jeffrey L. Johnson,Jason L. Sperry,Avery B. Nathens,Timothy R. Billiar,Michael West,Bernard H. Brownstein,Philip H. Mason,Henry V. Baker,Celeste C. Finnerty,Marc G. Jeschke,M. Cecilia Lopez,Matthew B. Klein,Richard L. Gamelli,Nicole S. Gibran,Brett D. Arnoldo,Weihong Xu,Yuping Zhang,Steven E. Calvano,Grace P. McDonald-Smith,David A. Schoenfeld,John D. Storey,J. Perren Cobb,H. Shaw Warren,Lyle L. Moldawer,David N. Herndon,Stephen F. Lowry,Ronald V. Maier,Ronald W. Davis,Ronald G. Tompkins,W. Xiao,M. Mindrinos,J. Seok,J. Cuschieri,R. Tompkins,Roger J. Davis,R. Maier,L. Moldawer,L. Hennessy,E. Moore,J. Minei,P. Bankey,J. Johnson,J. Sperry,A. Nathens,T. Billiar,M. West,B. Brownstein,D. Herndon,H. Baker,C. Finnerty,M. Jeschke,M. Lopez,M. Klein,R. Gamelli,N. Gibran,B. Arnoldo,G. McDonald-Smith,D. Schoenfeld,J. P. Cobb,Shaw Warren,A. Cuenca,S. Lowry,S. Calvano,Doug Hayden,P. Mason,H. Gao,J. Storey,Lily L. Altstein,Ulysses J. Balis,David G. Camp,K. De Asit,Brian G. Harbrecht,Shari Honari,Bruce A. McKinley,Carol L. Miller-Graziano,Frederick A. Moore,Grant E. O'Keefe,Laurence G. Rahme,Daniel G. Remick,Michael B. Shapiro,Richard D. Smith,Robert Tibshirani,Mehmet Toner,Bram Wispelwey,Wing Hung Wong +96 more
TL;DR: It is shown that critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes that alter the status of these genes in the immune system.
Journal ArticleDOI
Bacterial Lipoprotein TLR2 Agonists Broadly Modulate Endothelial Function and Coagulation Pathways In Vitro and In Vivo
Hae-Sook Shin,Fengyun Xu,Aranya Bagchi,Elizabeth A. Herrup,Arun Prakash,Catherine Valentine,Hrishikesh S. Kulkarni,Kevin Wilhelmsen,Shaw Warren,Judith Hellman +9 more
TL;DR: It is shown that TLR2 activation by bacterial lipoproteins broadly affects endothelial function and coagulation pathways, suggesting that TLr2 activation contributes in multiple ways to endothelial activation, coagulopathy, and vascular leakage in sepsis.
Patent
Gene-based clinical scoring system
TL;DR: In this article, systems and methods comprising microarray systems to assess prognostic potential in a clinical setting are described, and methods to assess the prognosis potential in clinical settings are described.
Pathways In Vitro and In Vivo Modulate Endothelial Function and Coagulation Bacterial Lipoprotein TLR2 Agonists Broadly
Kevin Wilhelmsen,Shaw Warren,Arun Prakash,Catherine Valentine,Hae-Sook Shin,Fengyun Xu,Aranya Bagchi +6 more
TL;DR: Of January 28, 2011This information is current ashttp://www.jimmunol.org/content/186/2/1119 doi:10.4049/J Immunol.1001647December 2010.