K
Karen R. Rabin
Researcher at Baylor College of Medicine
Publications - 124
Citations - 3171
Karen R. Rabin is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 23, co-authored 97 publications receiving 2311 citations. Previous affiliations of Karen R. Rabin include Boston Children's Hospital & Center for Cell and Gene Therapy.
Papers
More filters
Journal ArticleDOI
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.
Charles G. Mullighan,J. Racquel Collins-Underwood,Letha A. Phillips,Michael G. Loudin,Wei Liu,Jinghui Zhang,Jing Ma,Elaine Coustan-Smith,Richard C. Harvey,Cheryl L. Willman,Fady M. Mikhail,Julia Meyer,Andrew J. Carroll,Richard T. Williams,Jinjun Cheng,Nyla A. Heerema,Giuseppe Basso,Andrea Pession,Ching-Hon Pui,Susana C. Raimondi,Stephen P. Hunger,James R. Downing,William L. Carroll,Karen R. Rabin +23 more
TL;DR: A recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2 is reported.
Journal ArticleDOI
PAX5 -driven subtypes of B-progenitor acute lymphoblastic leukemia
Zhaohui Gu,Michelle L. Churchman,Kathryn G. Roberts,Ian Moore,Xin Zhou,Joy Nakitandwe,Kohei Hagiwara,Stephane Pelletier,Sebastien Gingras,Hartmut Berns,Debbie Payne-Turner,Ashley Hill,Ilaria Iacobucci,Lei Shi,Stanley Pounds,Cheng Cheng,Deqing Pei,Chunxu Qu,Scott Newman,Meenakshi Devidas,Yunfeng Dai,Shalini C. Reshmi,Julie M. Gastier-Foster,Elizabeth A. Raetz,Michael J. Borowitz,Brent L. Wood,William L. Carroll,Patrick A. Zweidler-McKay,Karen R. Rabin,Leonard A. Mattano,Kelly W. Maloney,Alessandro Rambaldi,Orietta Spinelli,Jerald P. Radich,Mark D. Minden,Jacob M. Rowe,Selina M. Luger,Mark R. Litzow,Martin S. Tallman,Janis Racevskis,Yanming Zhang,Ravi Bhatia,Jessica Kohlschmidt,Krzysztof Mrózek,Clara D. Bloomfield,Wendy Stock,Steven M. Kornblau,Hagop M. Kantarjian,Marina Konopleva,Williams E. Evans,Sima Jeha,Ching-Hon Pui,Jun J. Yang,Elisabeth Paietta,James R. Downing,Mary V. Relling,Jinghui Zhang,Mignon L. Loh,Stephen P. Hunger,Charles G. Mullighan +59 more
TL;DR: Analysis of 1,988 cases of B-cell acute lymphoblastic leukemia characterizes 23 subtypes defined by genomic features and shows that two of the subtypes have frequent PAX5 alterations, demonstrating the utility of transcriptome sequencing to classify B-ALL.
Journal ArticleDOI
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
Shalini C. Reshmi,Shalini C. Reshmi,Richard C. Harvey,Kathryn G. Roberts,Eileen Stonerock,Amy Smith,Heather Jenkins,I-Ming Chen,Marc Valentine,Yu Liu,Yongjin Li,Ying Shao,John Easton,Debbie Payne-Turner,Zhaohui Gu,Thai Hoa Tran,Jonathan V. Nguyen,Meenakshi Devidas,Yunfeng Dai,Nyla A. Heerema,Andrew J. Carroll,Elizabeth A. Raetz,Michael J. Borowitz,Brent L. Wood,Anne L. Angiolillo,Michael J. Burke,Wanda L. Salzer,Patrick A. Zweidler-McKay,Karen R. Rabin,William L. Carroll,Jinghui Zhang,Mignon L. Loh,Charles G. Mullighan,Cheryl L. Willman,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Stephen P. Hunger +36 more
TL;DR: The current findings provide support for the precision-medicine testing and treatment approach for Ph-like ALL implemented in Children's Oncology Group ALL trials.
Journal ArticleDOI
High frequency of germline p53 mutations in childhood adrenocortical cancer.
Josephine Wagner,Carol Portwine,Karen R. Rabin,Jean-Marie Leclerc,Steven A. Narod,David Malkin +5 more
TL;DR: Investigation of the possibility that germline TP53 gene alterations existed in children with sporadic adrenocortical carcinoma suggests that these children may represent probands with which to ascertain Li-Fraumeni syndrome families.
Journal ArticleDOI
The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia.
Rayne H. Rouce,Rayne H. Rouce,Hila Shaim,Takuya Sekine,Gerrit Weber,Brandon Ballard,Stephanie Ku,Cecilia Barese,Vineeth Kumar Murali,Meng-Fen Wu,Hao Liu,Elizabeth J. Shpall,Catherine M. Bollard,Catherine M. Bollard,Karen R. Rabin,Katayoun Rezvani +15 more
TL;DR: It is shown that by regulating the TGF-β/SMAD pathway, ALL blasts induce changes in NK cells to evade innate immune surveillance, thus highlighting the importance of developing novel therapies to target this inhibitory pathway and restore antileukemic cytotoxicity.