J
Joshua T. Herbeck
Researcher at University of Washington
Publications - 70
Citations - 2603
Joshua T. Herbeck is an academic researcher from University of Washington. The author has contributed to research in topics: Population & Viral load. The author has an hindex of 28, co-authored 61 publications receiving 2279 citations. Previous affiliations of Joshua T. Herbeck include University of California, Berkeley & Marine Biological Laboratory.
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Journal ArticleDOI
Founder effects in the assessment of HIV polymorphisms and HLA allele associations.
Tanmoy Bhattacharya,Tanmoy Bhattacharya,Marcus Daniels,David Heckerman,Brian T. Foley,Nicole Frahm,Carl M. Kadie,Jonathan M. Carlson,Jonathan M. Carlson,Karina Yusim,Ben H. McMahon,Brian Gaschen,Simon Mallal,James I. Mullins,David C. Nickle,Joshua T. Herbeck,Christine Rousseau,Gerald H. Learn,Toshiyuki Miura,Christian Brander,Bruce D. Walker,Bruce D. Walker,Bette T. Korber,Bette T. Korber +23 more
TL;DR: It is shown that viral lineage effects rather than immune escape often explain apparent human leukocyte antigen (HLA)–mediated immune-escape mutations defined by older analysis methods.
Journal ArticleDOI
Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis
Joris Hemelaar,Ramyiadarsini Elangovan,Jason Yun,Leslie Dickson-Tetteh,Isabella Fleminger,Shona Kirtley,Brian G. Williams,Eleanor Gouws-Williams,Peter D. Ghys,Alash'le Abimiku,Simon Agwale,Chris P. Archibald,Boaz Avidor,María Gabriela Barbás,Françoise Barré-Sinoussi,Banson Barugahare,El Hadj Belabbes,Silvia Bertagnolio,Deborah L. Birx,Aleksei F Bobkov,James Brandful,Helba Bredell,Catherine A. Brennan,James Brooks,Marie Bruckova,Luigi Buonaguro,Franco M. Buonaguro,Stefano Buttò,Anne Buvé,Mary S. Campbell,Jean K. Carr,Alex Carrera,Manuel Gómez Carrillo,Connie Celum,Beth Chaplin,Macarthur Charles,Dimitrios Chatzidimitriou,Zhiwei Chen,Katsumi Chijiwa,David Cooper,Philip Cunningham,Anoumou Y. Dagnra,Cillian De Gascun,Julia del Amo,Elena Delgado,Ursula Dietrich,Dominic M. Dwyer,Dennis Ellenberger,Barbara Ensoli,Max Essex,Feng Gao,Hervé Fleury,Peter N. Fonjungo,Vincent Foulongne,Deepak A Gadkari,Federico García,Roger Garsia,Guy Michel Gershy-Damet,Judith R. Glynn,Ruth Goodall,Zehava Grossman,Monick Lindenmeyer-Guimarães,Beatrice H. Hahn,Raph L. Hamers,Osamah Hamouda,Ray Handema,Xiang He,Joshua T. Herbeck,David D. Ho,África Holguín,Mina C. Hosseinipour,Gillian Hunt,Masahiko Ito,Mohamed Ali Bel Hadj Kacem,Erin M. Kahle,Pontiano Kaleebu,Marcia L. Kalish,Adeeba Kamarulzaman,Chun Kang,Phyllis J. Kanki,Edward Karamov,Jean-Claude Karasi,Kayitesi Kayitenkore,Tony Kelleher,Dwip Kitayaporn,Leondios G. Kostrikis,Claudia Kücherer,Claudia Lara,Thomas Leitner,Kirsi Liitsola,J.R. Lingappa,Marek Linka,Ivette Lorenzana de Rivera,Vladimir Lukashov,Shlomo Maayan,Luzia Mayr,Francine E. McCutchan,Nicolas Meda,Elisabeth Menu,Fred Mhalu,Doreen Mloka,John L. Mokili,Brigitte Montes,Orna Mor,Mariza G. Morgado,Fausta Mosha,Awatef Moussi,James I. Mullins,Rafael Nájera,Mejda Nasr,Nicaise Ndembi,Joel R. Neilson,Vivek R. Nerurkar,Florian Neuhann,Claudine Nolte,Vlad Novitsky,Philippe Nyambi,Marianna Ofner,Fem J Paladin,Anna Papa,Jean Pape,Neil Parkin,Christopher M. Parry,Martine Peeters,Alexandra Pelletier,Lucía Pérez-Álvarez,Deenan Pillay,Angie N Pinto,Trinh Duy Quang,Cecilia Rademeyer,Filimone Raikanikoda,Mark A. Rayfield,Jean-Marc Reynes,Tobias F. Rinke de Wit,Kenneth E. Robbins,Morgane Rolland,Christine Rousseau,Jesus Salazar-Gonzales,Hanan Salem,Mika Salminen,Horacio Salomon,Paul Sandstrom,Mario L. Santiago,Abdoulaye Dieng Sarr,Bryan Schroeder,Michel Segondy,Philippe Selhorst,Sylvester Sempala,Jean Servais,Ansari Shaik,Yiming Shao,Amine Slim,Marcelo A. Soares,Elijah M. Songok,Debbie Stewart,Julie Stokes,Shambavi Subbarao,Ruengpung Sutthent,Jun Takehisa,Amilcar Tanuri,Kok Keng Tee,Kiran Thapa,Michael M. Thomson,Tyna Tran,Willy Urassa,Hiroshi Ushijima,Philippe Van de Perre,Guido van der Groen,Kristel Van Laethem,Joep J. van Oosterhout,Ard van Sighem,Eric Van Wijngaerden,Anne-Mieke Vandamme,Jurgen Vercauteren,Nicole Vidal,Lesley Wallace,Carolyn Williamson,Dawit Wolday,Jianqing Xu,Chunfu Yang,Linqi Zhang,Rong Zhang +181 more
TL;DR: The distribution of HIV-1 subtypes and recombinants changed over time in countries, regions, and globally as well as at a global level during 2005-15, where subtype B increased, subtypes A and D were stable, and subtypes C and G and CRF02_AG decreased.
Journal ArticleDOI
CD39/Adenosine Pathway Is Involved in AIDS Progression
Maria Nikolova,Matthieu Carrière,Mohammad-Ali Jenabian,Sophie Limou,Sophie Limou,Mehwish Younas,Ayrin Kök,Sophie Hue,Nabila Seddiki,Anne Hulin,Olivier Delaneau,Hanneke Schuitemaker,Joshua T. Herbeck,James I. Mullins,Maria Muhtarova,Armand Bensussan,Jean-François Zagury,Jean-François Zagury,Jean-Daniel Lelièvre,Jean-Daniel Lelièvre,Yves Levy,Yves Levy +21 more
TL;DR: It is shown in vitro that the CD39/adenosine axis is involved in Treg suppression in HIV infection and a genetic association study identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS.
Journal ArticleDOI
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
Paul J. McLaren,Paul J. McLaren,Cédric Coulonges,Istvan Bartha,Istvan Bartha,Tobias L. Lenz,Aaron J. Deutsch,Aaron J. Deutsch,Aaron J. Deutsch,Arman Bashirova,Susan Buchbinder,Mary Carrington,Mary Carrington,Andrea Cossarizza,Judith Dalmau,Andrea De Luca,James J. Goedert,Deepti Gurdasani,Deepti Gurdasani,David W. Haas,Joshua T. Herbeck,Eric O. Johnson,Gregory D. Kirk,Olivier Lambotte,Ma Luo,Simon Mallal,Daniëlle van Manen,Javier Martinez-Picado,Javier Martinez-Picado,Laurence Meyer,José M. Miró,James I. Mullins,Niels Obel,Guido Poli,Guido Poli,Manjinder S. Sandhu,Manjinder S. Sandhu,Hanneke Schuitemaker,Patrick R. Shea,Ioannis Theodorou,Bruce D. Walker,Bruce D. Walker,Amy C. Weintrob,Cheryl A. Winkler,Steven M. Wolinsky,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,David Goldstein,Amalio Telenti,Paul I.W. de Bakker,Jean-François Zagury,Jacques Fellay,Jacques Fellay +53 more
TL;DR: Heritability analysis demonstrated that common human genetic variation—mostly in the HLA and CCR5 regions—explains 25% of the variability in viral load.
Journal ArticleDOI
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls
Paul J. McLaren,Paul J. McLaren,Paul J. McLaren,Cédric Coulonges,Stephan Ripke,Stephan Ripke,Leonard H. van den Berg,Susan Buchbinder,Mary Carrington,Mary Carrington,Andrea Cossarizza,Judith Dalmau,Steven G. Deeks,Olivier Delaneau,Andrea De Luca,James J. Goedert,David W. Haas,Joshua T. Herbeck,Sekar Kathiresan,Sekar Kathiresan,Gregory D. Kirk,Olivier Lambotte,Olivier Lambotte,Ma Luo,Ma Luo,Simon Mallal,Daniëlle van Manen,Daniëlle van Manen,Javier Martinez-Picado,Laurence Meyer,José M. Miró,James I. Mullins,Niels Obel,Stephen J. O'Brien,Florencia Pereyra,Florencia Pereyra,Francis A. Plummer,Francis A. Plummer,Guido Poli,Ying Qi,Pierre Rucart,M. S. Sandhu,M. S. Sandhu,Patrick R. Shea,Hanneke Schuitemaker,Hanneke Schuitemaker,Ioannis Theodorou,Fredrik O. Vannberg,Jan H. Veldink,Bruce D. Walker,Bruce D. Walker,Amy C. Weintrob,Cheryl A. Winkler,Steven M. Wolinsky,Amalio Telenti,David Goldstein,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jean-François Zagury,Jacques Fellay,Jacques Fellay +61 more
TL;DR: Analysis of genome-wide single nucleotide polymorphism data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets suggest that genetic influences on HIV acquisition are either rare or have smaller effects than can be detected by this sample size.