M
Margaret P. Price
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 52
Citations - 9030
Margaret P. Price is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Acid-sensing ion channel & Mechanosensation. The author has an hindex of 38, co-authored 51 publications receiving 8508 citations. Previous affiliations of Margaret P. Price include University of Iowa & Howard Hughes Medical Institute.
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Journal ArticleDOI
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.
Zhi-Gang Xiong,Xiao-Man Zhu,Xiang-Ping Chu,Manabu Minami,Jessica G. Hey,Wen-Li Wei,John F. MacDonald,John A. Wemmie,John A. Wemmie,John A. Wemmie,Margaret P. Price,Michael J. Welsh,Roger P. Simon +12 more
TL;DR: It is shown that acidosis activates Ca2+ -permeable acid-sensing ion channels (ASICs), inducing glutamate receptor-independent, Ca2-dependent, neuronal injury inhibited by ASIC blockers, and disclosing new potential therapeutic targets for stroke.
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The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.
John A. Wemmie,Jianguo Chen,Jianguo Chen,Candice C. Askwith,Candice C. Askwith,Alesia Hruska-Hageman,Alesia Hruska-Hageman,Margaret P. Price,Brian C. Nolan,Patrick G. Yoder,Ejvis Lamani,Toshinori Hoshi,Toshinori Hoshi,John H. Freeman,Michael J. Welsh,Michael J. Welsh +15 more
TL;DR: It is found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons, and null mice displayed defective spatial learning and eyeblink conditioning.
Journal ArticleDOI
The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
Margaret P. Price,Sabrina L. McIlwrath,Jinghui Xie,Chun Cheng,Jing Qiao,Deirdre E. Tarr,Kathleen A. Sluka,Timothy J. Brennan,Gary R. Lewin,Michael J. Welsh,Michael J. Welsh +10 more
TL;DR: The data suggest that DRASic subunits participate in heteromultimeric channel complexes in sensory neurons, and in different cellular contexts, DRASIC may respond to mechanical stimuli or to low pH to mediate normal touch and pain sensation.
Journal ArticleDOI
Acid-sensing ion channels: advances, questions and therapeutic opportunities
TL;DR: Advances in understanding of acid-sensing ion channels, their potential contributions to disease, and the possibility for their therapeutic modification are reviewed.
Journal ArticleDOI
The mammalian sodium channel BNC1 is required for normal touch sensation.
Margaret P. Price,Gary R. Lewin,Sabrina L. McIlwrath,Chun Cheng,Jinghui Xie,Paul A. Heppenstall,Cheryl L. Stucky,Annne G. Mannsfeldt,Timothy J. Brennan,Heather A. Drummond,Jing Qiao,Christopher J. Benson,Delrdre E. Tarr,Ron F. Hrstka,Baoli Yang,Roger A. Williamson,Michael J. Welsh +16 more
TL;DR: It is shown that disrupting the mouse BNC1 gene markedly reduces the sensitivity of a specific component of mechanosensation: low-threshold rapidly adapting mechanoreceptors, and this data identify the B NC1 channel as essential for the normal detection of light touch and indicate that BNC 1 may be a central component of a mechanosensory complex.