Journal ArticleDOI
Acid-sensing ion channels: advances, questions and therapeutic opportunities
TLDR
Advances in understanding of acid-sensing ion channels, their potential contributions to disease, and the possibility for their therapeutic modification are reviewed.About:
This article is published in Trends in Neurosciences.The article was published on 2006-10-01. It has received 521 citations till now. The article focuses on the topics: Acid-sensing ion channel & Mechanosensation.read more
Citations
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Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
Journal ArticleDOI
Acid-sensing ion channels in pain and disease
TL;DR: This Review highlights recent findings linking these channels to physiology and disease, and discusses some of the implications for therapy and points out questions that remain unanswered.
Journal ArticleDOI
Activation and Regulation of Purinergic P2X Receptor Channels
TL;DR: Data obtained from numerous site-directed mutagenesis experiments accumulated during the last 15 years are discussed with reference to the crystal structure, allowing a structural interpretation of the molecular basis of orthosteric and allosteric ligand actions.
Journal ArticleDOI
TRPA1 Is a Major Oxidant Sensor in Murine Airway Sensory Neurons
Bret F. Bessac,Michael Sivula,Christian A. A. von Hehn,Jasmine Escalera,Lauren Cohn,Sven-Eric Jordt +5 more
TL;DR: It is shown that both hypochlorite, the oxidizing mediator of chlorine, and hydrogen peroxide, a reactive oxygen species, activated Ca(2+) influx and membrane currents in an oxidant-sensitive subpopulation of chemosensory neurons.
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Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.
Manuel A. Friese,Matthew Craner,Ruth Etzensperger,Sandra Vergo,John A. Wemmie,Michael J. Welsh,Angela Vincent,Lars Fugger,Lars Fugger +8 more
TL;DR: Results suggest that ASIC1 blockers could provide neuroprotection in multiple sclerosis, as adoptive transfer of T cells from wild-type mice did not affect the protection mediated by Asic1 disruption.
References
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Journal ArticleDOI
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
TL;DR: PHluorins are developed pH-sensitive mutants of green fluorescent protein by structure-directed combinatorial mutagenesis, with the aim of exploiting the acidic pH inside secretory vesicles, to monitor vesicle exocytosis and recycling.
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A proton-gated cation channel involved in acid-sensing
TL;DR: The biophysical and pharmacological properties of the cloned H+-gated channel (ASIC), for acid-sensing ionic channel that belongs to the amilor-ide-sensitive Na+ channel6–1 Vdegenerin12–14 family of ion channels, closely match those described in sensory neurons.
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False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis.
TL;DR: The phenomena of panic during relaxation and sleep, late luteal phase dysphoric disorder, pregnancy, childbirth, pulmonary disease, separation anxiety, and treatment are used to test and illuminate the suffocation false alarm theory.
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Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.
TL;DR: The functional heterogeneity among the members of the ENaC/DEG channel family provides a unique opportunity to address the molecular basis of basic channel functions such as activation by ligands, mechanotransduction, ionic selectivity, or block by pharmacological ligands.
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Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.
Zhi-Gang Xiong,Xiao-Man Zhu,Xiang-Ping Chu,Manabu Minami,Jessica G. Hey,Wen-Li Wei,John F. MacDonald,John A. Wemmie,John A. Wemmie,John A. Wemmie,Margaret P. Price,Michael J. Welsh,Roger P. Simon +12 more
TL;DR: It is shown that acidosis activates Ca2+ -permeable acid-sensing ion channels (ASICs), inducing glutamate receptor-independent, Ca2-dependent, neuronal injury inhibited by ASIC blockers, and disclosing new potential therapeutic targets for stroke.