M
Mariko L. Bennett
Researcher at Children's Hospital of Philadelphia
Publications - 28
Citations - 13224
Mariko L. Bennett is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Microglia & Medicine. The author has an hindex of 14, co-authored 21 publications receiving 9052 citations. Previous affiliations of Mariko L. Bennett include Stanford University & University of Pennsylvania.
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Journal ArticleDOI
Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow,Kevin A. Guttenplan,Laura E. Clarke,Frederick C. Bennett,Christopher J. Bohlen,Lucas Schirmer,Mariko L. Bennett,Alexandra E. Münch,Won-Suk Chung,Todd C. Peterson,Daniel K. Wilton,Arnaud Frouin,Brooke A. Napier,Nikhil Panicker,Manoj Kumar,Marion S. Buckwalter,David H. Rowitch,Valina L. Dawson,Ted M. Dawson,Beth Stevens,Ben A. Barres +20 more
TL;DR: It is shown that activated microglia induce A1 astrocytes by secreting Il-1α, TNF and C1q, and that these cytokines together are necessary and sufficient to induce A2 astroCytes, which are abundant in various human neurodegenerative diseases.
Journal ArticleDOI
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Ye Zhang,Kenian Chen,Steven A. Sloan,Mariko L. Bennett,Anja R. Scholze,Sean O'Keeffe,Hemali Phatnani,Paolo Guarnieri,Christine Caneda,Nadine Ruderisch,Shuyun Deng,Shane A. Liddelow,Chaolin Zhang,Richard Daneman,Tom Maniatis,Ben A. Barres,Jian Qian Wu +16 more
TL;DR: The authors' data provide clues as to how neurons and astrocytes differ in their ability to dynamically regulate glycolytic flux and lactate generation attributable to unique splicing of PKM2, the gene encoding the glycoleytic enzyme pyruvate kinase.
Journal ArticleDOI
New tools for studying microglia in the mouse and human CNS.
Mariko L. Bennett,F. Chris Bennett,Shane A. Liddelow,Shane A. Liddelow,Bahareh Ajami,Jennifer L. Zamanian,Nathaniel B. Fernhoff,Sara B. Mulinyawe,Christopher J. Bohlen,Aykezar Adil,Andrew Tucker,Irving L. Weissman,Edward F. Chang,Gordon Li,Gerald A. Grant,Melanie Hayden Gephart,Ben A. Barres +16 more
TL;DR: Transmembrane protein 119 (Tmem119), a cell-surface protein of unknown function, is identified as a highly expressed microglia-specific marker in both mouse and human, which will greatly facilitate understanding of microglial function in health and disease.
Journal ArticleDOI
Microglia: Scapegoat, Saboteur, or Something Else?
TL;DR: Although microglial activation is often considered neurotoxic, microglia are essential defenders against many neurodegenerative diseases.
Journal ArticleDOI
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
Nicola J. Allen,Mariko L. Bennett,Lynette C. Foo,Gordon X. Wang,Chandrani Chakraborty,Stephen J. Smith,Ben A. Barres +6 more
TL;DR: Glypicans is identified as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses.