Marion Klemm

TL;DR: It is demonstrated that AhR senses distinct bacterial virulence factors and controls antibacterial responses, supporting a previously unidentified role for AhR as an intracellular pattern recognition receptor, and identifying bacterial pigments as a new class of pathogen-associated molecular patterns.

TL;DR: The aryl hydrocarbon receptor (AhR) directly recognizes pigmented bacterial virulence factors, such as the phenazines produced by Pseudomonas aeruginosa, which are downstream products of QS, and signals to the host to tune immune responses according to the stage and state of infection.

TL;DR: Endocytosis facilitates internalization of eCDNs, and the DNA sensor cGAS facilitates sensing of endocytosed CDNs, their perinuclear accumulation, and subsequent STING‐dependent release of type I IFN.

TL;DR: Insight is provided into the induction and regulation of the proinflammatory cytokine IL-36γ during tuberculosis, a recently described member of the IL-1 family, and its immunological relevance in host defense remain largely unknown.

TL;DR: It is demonstrated that in the context of therapy, the AhR binds several TB drugs, including front line drugs rifampicin and rifabutin, resulting in altered host defense and drug metabolism, and proposed as a potential target for HDT in TB in adjunct to canonical chemotherapy.