M
Marion Klemm
Researcher at Max Planck Society
Publications - 7
Citations - 503
Marion Klemm is an academic researcher from Max Planck Society. The author has contributed to research in topics: Aryl hydrocarbon receptor & Lawsone. The author has an hindex of 6, co-authored 7 publications receiving 356 citations.
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Journal ArticleDOI
AhR sensing of bacterial pigments regulates antibacterial defence
Pedro Moura-Alves,Kellen C. Faé,Erica Houthuys,Anca Dorhoi,Annika Kreuchwig,Jens Furkert,Nicola Barison,Anne Diehl,Antje Munder,Patricia Constant,Tatsiana Skrahina,Ute Guhlich-Bornhof,Marion Klemm,Anne-Britta Koehler,Silke Bandermann,Christian Goosmann,Hans-Joachim Mollenkopf,Robert Hurwitz,Volker Brinkmann,Simon Fillatreau,Mamadou Daffé,Burkhard Tümmler,Michael Kolbe,Hartmut Oschkinat,Gerd Krause,Stefan H. E. Kaufmann +25 more
TL;DR: It is demonstrated that AhR senses distinct bacterial virulence factors and controls antibacterial responses, supporting a previously unidentified role for AhR as an intracellular pattern recognition receptor, and identifying bacterial pigments as a new class of pathogen-associated molecular patterns.
Journal ArticleDOI
Host Monitoring of Quorum Sensing During Pseudomonas aeruginosa Infection
Pedro Moura-Alves,Pedro Moura-Alves,Andreas Puyskens,Anne Stinn,Marion Klemm,Ute Guhlich-Bornhof,Anca Dorhoi,Anca Dorhoi,Anca Dorhoi,Jens Furkert,Annika Kreuchwig,Jonas Protze,Laura Lozza,Gang Pei,Philippe Saikali,Carolina Perdomo,Hans J. Mollenkopf,Robert Hurwitz,Frank Kirschhoefer,Gerald Brenner-Weiss,January Weiner,Hartmut Oschkinat,Michael Kolbe,Michael Kolbe,Gerd Krause,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann +26 more
TL;DR: The aryl hydrocarbon receptor (AhR) directly recognizes pigmented bacterial virulence factors, such as the phenazines produced by Pseudomonas aeruginosa, which are downstream products of QS, and signals to the host to tune immune responses according to the stage and state of infection.
Journal ArticleDOI
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
Haipeng Liu,Haipeng Liu,Pedro Moura-Alves,Gang Pei,Hans-Joachim Mollenkopf,Robert Hurwitz,Xiangyang Wu,Fei Wang,Siyu Liu,Mingtong Ma,Yiyan Fei,Chenggang Zhu,Anne-Britta Koehler,Dagmar Oberbeck-Mueller,Karin Hahnke,Marion Klemm,Ute Guhlich-Bornhof,Baoxue Ge,Anne Tuukkanen,Michael Kolbe,Anca Dorhoi,Anca Dorhoi,Anca Dorhoi,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann +24 more
TL;DR: Endocytosis facilitates internalization of eCDNs, and the DNA sensor cGAS facilitates sensing of endocytosed CDNs, their perinuclear accumulation, and subsequent STING‐dependent release of type I IFN.
Journal ArticleDOI
Role of Interleukin 36γ in Host Defense Against Tuberculosis
Fadhil Ahsan,Pedro Moura-Alves,Ute Guhlich-Bornhof,Marion Klemm,Stefan H. E. Kaufmann,Jeroen Maertzdorf +5 more
TL;DR: Insight is provided into the induction and regulation of the proinflammatory cytokine IL-36γ during tuberculosis, a recently described member of the IL-1 family, and its immunological relevance in host defense remain largely unknown.
Journal ArticleDOI
Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes
Andreas Puyskens,Anne Stinn,Michiel van der Vaart,Annika Kreuchwig,Jonas Protze,Gang Pei,Marion Klemm,Ute Guhlich-Bornhof,Robert Hurwitz,Gopinath Krishnamoorthy,Marcel J. M. Schaaf,Gerd Krause,Annemarie H. Meijer,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann,Pedro Moura-Alves,Pedro Moura-Alves +16 more
TL;DR: It is demonstrated that in the context of therapy, the AhR binds several TB drugs, including front line drugs rifampicin and rifabutin, resulting in altered host defense and drug metabolism, and proposed as a potential target for HDT in TB in adjunct to canonical chemotherapy.