M
Marios Politis
Researcher at King's College London
Publications - 167
Citations - 9497
Marios Politis is an academic researcher from King's College London. The author has contributed to research in topics: Parkinson's disease & Serotonergic. The author has an hindex of 47, co-authored 158 publications receiving 7504 citations. Previous affiliations of Marios Politis include Hammersmith Hospital & King's College.
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Journal ArticleDOI
Cognitive decline in Parkinson disease
Dag Aarsland,Byron Creese,Byron Creese,Marios Politis,K. Ray Chaudhuri,Dominic Ffytche,Daniel Weintraub,Daniel Weintraub,Daniel Weintraub,Clive Ballard,Clive Ballard +10 more
TL;DR: New genetic evidence indicates that in addition to the APOE*ε4 allele (an established risk factor for AD), GBA mutations and SCNA mutations and triplications are associated with cognitive decline in PD, whereas the findings are mixed for MAPT polymorphisms.
Journal ArticleDOI
Parkinson's Disease Symptoms: The Patient's Perspective
TL;DR: It is suggested that as the disease advances the most troublesome issues that patients perceive are the lack of response to medication and the nonmotor aspects of the disease, highlighting the importance of assessment and patient‐centered management in the follow-up of these patients.
Journal ArticleDOI
Clinical application of stem cell therapy in Parkinson's disease
Marios Politis,Olle Lindvall +1 more
TL;DR: It is unlikely that transplantation of hfVM tissue will become routine treatment for PD owing to problems with tissue availability and standardization of the grafts, but the main focus now is on producing DA-ergic neuroblasts for transplantation from stem cells (SCs).
Journal ArticleDOI
Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson’s Patients with Neural Transplants
Marios Politis,Kit Wu,Clare Loane,Niall Quinn,David J. Brooks,Stig Rehncrona,Anders Björklund,Olle Lindvall,Paola Piccini +8 more
TL;DR: Two patients with Parkinson’s disease, successfully treated with fetal tissue transplants more than a decade ago, developed troublesome involuntary movements, which were determined to be a result of an overabundance of serotonin-using neurons that developed from the graft, and strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease are suggested.
Journal ArticleDOI
Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours
Sean S. O'Sullivan,Sean S. O'Sullivan,Kit Wu,Marios Politis,Andrew D. Lawrence,Andrew Evans,Subrata K. Bose,Atbin Djamshidian,Andrew J. Lees,Paola Piccini +9 more
TL;DR: The heightened response of striatal reward circuitry to heterogeneous reward-related visual cues among a group of patients with different impulsive-compulsive behaviours is consistent with a global sensitization to appetitive behaviours with dopaminergic therapy in vulnerable individuals.