Mark E. Ridgeway

TL;DR: A guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values.

TL;DR: A quantitative theory for TIMS, a relatively new gas-phase separation method that has been coupled to quadrupole orthogonal acceleration time-of-flight mass spectrometry, is developed via mathematical derivation and simulations.

TL;DR: Trapped ion mobility spectrometry (TIMS) is a relatively recent advance in the field of ion mobility mass spectrometer (IMMS) as mentioned in this paper, which holds the ions stationary in a moving column of gas.

TL;DR: Results showed that a maximal mobility resolution can be achieved by optimizing the gas velocity, radial confinement (RF amplitude) and ramp speed (voltage range and ramp time) in a trapped ion mobility spectrometer.

TL;DR: TIMS not only is able to resolve congested conformational features but also can be used to determine information about their relative size, via the ion-neutral collision cross section, offering a powerful new platform to probe the structure and dynamics of biochemical systems in the gas phase.