Haruko Yamamoto

TL;DR: The treatment of participants with intracerebral hemorrhage to achieve a target systolic blood pressure of 110 to 139mm Hg did not result in a lower rate of death or disability than standard reduction to a target of 140 to 179 mm Hg.

TL;DR: Although expansion of intracerebral hemorrhage on CT scan was common in the hyperacute stage, 17% of hematoma expansion occurred even after 6 hours of onset, early CT scanning appears to increase the rate of detection of enlarging hematomas.

TL;DR: In this large patient-level meta-analysis, models using four or five predictors had acceptable to good discrimination and could inform the location and frequency of observations on patients in clinical practice, explain treatment effects in prior randomised trials, and guide the design of future trials.

TL;DR: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care despite an increased risk of symptomatic intracranial haemorrhage.

TL;DR: No difference in favorable outcome was seen between alteplase and control groups among patients with ischemic stroke with unknown time of onset and the safety of altePlase at 0.6 mg/kg was comparable to that of standard treatment.