M
Mark Woodward
Researcher at Bristol Royal Hospital for Children
Publications - 35
Citations - 2023
Mark Woodward is an academic researcher from Bristol Royal Hospital for Children. The author has contributed to research in topics: Neural crest & Embryonic stem cell. The author has an hindex of 13, co-authored 34 publications receiving 1699 citations. Previous affiliations of Mark Woodward include University of Bristol & University Hospitals Bristol NHS Foundation Trust.
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Journal ArticleDOI
Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: A pooled analysis of 97 prospective cohorts with 1·8 million participants
TL;DR: How much of the effects of BMI on coronary heart disease and stroke are mediated through blood pressure, cholesterol, and glucose, and how much is independent of these factors is quantified.
Journal ArticleDOI
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Nadeem Sarwar,Adam S. Butterworth,Daniel F. Freitag,John Gregson,Peter Willeit,Donal Gorman,Pei Gao,Danish Saleheen,Augusto Rendon,Christopher P. Nelson,Peter S. Braund,Alistair S. Hall,Daniel I. Chasman,Anne Tybjærg-Hansen,John C. Chambers,Emelia J. Benjamin,Paul W. Franks,Robert Clarke,Arthur A. M. Wilde,Mieke D. Trip,Maristella Steri,Jacqueline C. M. Witteman,Lu Qi,C. Ellen van der Schoot,Ulf de Faire,Jeanette Erdmann,Heather M. Stringham,Wolfgang Koenig,Daniel J. Rader,David Melzer,David Reich,Bruce M. Psaty,Marcus E. Kleber,Demosthenes B. Panagiotakos,Johann Willeit,Patrik Wennberg,Mark Woodward,Svetlana Adamovic,Eric B. Rimm,Tom W. Meade,Richard F. Gillum,Jonathan A. Shaffer,Albert Hofman,Altan Onat,Johan Sundström,S. Wassertheil-Smoller,Dan Mellström,John Gallacher,Mary Cushman,Russell P. Tracy,Jussi Kauhanen,Magnus Karlsson,Jukka T. Salonen,Lars Wilhelmsen,Philippe Amouyel,Bernard Cantin,Lyle G. Best,Yoav Ben-Shlomo,JoAnn E. Manson,George Davey-Smith,Paul I.W. de Bakker,Christopher J. O'Donnell,James F. Wilson,Anthony G. Wilson,Themistocles L. Assimes,John-Olov Jansson,Claes Ohlsson,Åsa Tivesten,Östen Ljunggren,Muredach P. Reilly,Anders Hamsten,Erik Ingelsson,François Cambien,Joseph Hung,G. Neil Thomas,Michael Boehnke,Heribert Schunkert,Folkert W. Asselbergs,John J.P. Kastelein,Vilmundur Gudnason,Veikko Salomaa,Tamara B. Harris,Jaspal S. Kooner,Kristine H. Allin,Kristine H. Allin,Børge G. Nordestgaard,Jemma C. Hopewell,Alison H. Goodall,Paul M. Ridker,Hilma Holm,Hugh Watkins,Willem H. Ouwehand,Nilesh J. Samani,Stephen Kaptoge,Emanuele Di Angelantonio,Olivier Harari,John Danesh +96 more
TL;DR: In this article, a functional genetic variant known to affect IL6R signalling was studied to assess whether this pathway is causally relevant to coronary heart disease, and Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking.
Journal ArticleDOI
Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum
Marion A. Leibl,T Ota,Mark Woodward,Simon E. Kenny,David A. Lloyd,Camille Vaillant,David Edgar +6 more
TL;DR: Mesenchymal cells of the caecum express high levels of EDN3 mRNA during embryogenesis and hence the production ofEDN3 at the caecaum is likely to act on neural crest cells as a paracrine factor necessary for subsequent innervation of the terminal gut.
Journal ArticleDOI
Clinical and genetic analysis of patients with cystinuria in the United Kingdom.
Hannah L Rhodes,Laura Yarram-Smith,Sarah J. Rice,Ayla Tabaksert,Noel Edwards,Alice Hartley,Mark Woodward,Sarah L. Smithson,Charles R.V. Tomson,Gavin I. Welsh,Margaret M. Williams,David T. Thwaites,John A. Sayer,John A. Sayer,Richard J M Coward +14 more
TL;DR: Patients with cystinuria in the United Kingdom often present atypically with staghorn calculi at ≥40 years old and commonly develop significant renal impairment, and treatments directed toward reducing stone burden need to be rationalized and developed to optimize patient care.
Journal ArticleDOI
Time-dependent effects of endothelin-3 on enteric nervous system development in an organ culture model of Hirschsprung's disease
TL;DR: An organ culture model has been developed in which NCC colonisation of embryonic gut mirrors that described in vivo, and blockade of the EDN3/EDNRB receptor pathway shows that the interaction of endothelin-3 with its receptor is only necessary for NCC Colonisation at early time-points, despite the continued expression of endethelin- 3 mRNA in the gut.