D
Daniel F. Freitag
Researcher at University of Cambridge
Publications - 29
Citations - 8132
Daniel F. Freitag is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 20, co-authored 26 publications receiving 6385 citations. Previous affiliations of Daniel F. Freitag include Wellcome Trust Sanger Institute & British Heart Foundation.
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Journal ArticleDOI
Discovery and refinement of loci associated with lipid levels
Cristen J. Willer,Ellen M. Schmidt,Sebanti Sengupta,Gina M. Peloso,Gina M. Peloso,Gina M. Peloso,Stefan Gustafsson,Stavroula Kanoni,Andrea Ganna,Andrea Ganna,Jin Chen,Martin L. Buchkovich,Samia Mora,Jacques S. Beckmann,Jennifer L. Bragg-Gresham,Hsing-Yi Chang,Ayse Demirkan,Heleen M. den Hertog,Ron Do,Louise A. Donnelly,Georg Ehret,Georg Ehret,Tõnu Esko,Tõnu Esko,Mary F. Feitosa,Teresa Ferreira,Krista Fischer,Pierre Fontanillas,Ross M. Fraser,Daniel F. Freitag,Deepti Gurdasani,Deepti Gurdasani,Kauko Heikkilä,Elina Hyppönen,Aaron Isaacs,Anne U. Jackson,Åsa Johansson,Toby Johnson,Marika Kaakinen,Johannes Kettunen,Johannes Kettunen,Marcus E. Kleber,Marcus E. Kleber,Xiaohui Li,Jian'an Luan,Leo-Pekka Lyytikäinen,Patrik K. E. Magnusson,Massimo Mangino,Evelin Mihailov,May E. Montasser,Martina Müller-Nurasyid,Ilja M. Nolte,Jeffrey R. O'Connell,Cameron D. Palmer,Cameron D. Palmer,Markus Perola,Markus Perola,Markus Perola,Ann-Kristin Petersen,Serena Sanna,Richa Saxena,Sonia Shah,Dmitry Shungin,Dmitry Shungin,Carlo Sidore,Carlo Sidore,Ci Song,Ci Song,Rona J. Strawbridge,Ida Surakka,Ida Surakka,Toshiko Tanaka,Tanya M. Teslovich,Gudmar Thorleifsson,Evita G. Van Den Herik,Benjamin F. Voight,Kelly A. Volcik,Lindsay L. Waite,Andrew Wong,Ying Wu,Weihua Zhang,Weihua Zhang,Devin Absher,Gershim Asiki,Inês Barroso,Inês Barroso,Inês Barroso,Latonya F. Been,Jennifer L. Bolton,Lori L. Bonnycastle,Paolo Brambilla,Mary Susan Burnett,Giancarlo Cesana,Maria Dimitriou,Alex S. F. Doney,Angela Döring,Paul Elliott,Paul Elliott,Stephen E. Epstein,Gudmundur I. Eyjolfsson,Bruna Gigante,Mark O. Goodarzi,Harald Grallert,Martha L. Gravito,Christopher J. Groves,Göran Hallmans,Anna-Liisa Hartikainen,Caroline Hayward,Dena G. Hernandez,Andrew A. Hicks,Hilma Holm,Yi Jen Hung,Thomas Illig,Matthew Jones,Pontiano Kaleebu,John J.P. Kastelein,Kay-Tee Khaw,Eric Kim,Norman Klopp,Pirjo Komulainen,Meena Kumari,Claudia Langenberg,Terho Lehtimäki,Shih-Yi Lin,Jaana Lindström,Ruth J. F. Loos,Ruth J. F. Loos,François Mach,Wendy L. McArdle,Christa Meisinger,Braxton D. Mitchell,Gabrielle Müller,Ramaiah Nagaraja,Narisu Narisu,Tuomo Nieminen,Rebecca N. Nsubuga,Isleifur Olafsson,Ken K. Ong,Ken K. Ong,Aarno Palotie,Aarno Palotie,Theodore Papamarkou,Theodore Papamarkou,Theodore Papamarkou,Cristina Pomilla,Cristina Pomilla,Anneli Pouta,Anneli Pouta,Daniel J. Rader,Muredach P. Reilly,Paul M. Ridker,Fernando Rivadeneira,Igor Rudan,Aimo Ruokonen,Nilesh J. Samani,Nilesh J. Samani,Hubert Scharnagl,Janet Seeley,Janet Seeley,Kaisa Silander,Kaisa Silander,Alena Stančáková,Kathleen Stirrups,Amy J. Swift,Laurence Tiret,André G. Uitterlinden,L. Joost van Pelt,Sailaja Vedantam,Sailaja Vedantam,Nicholas W.J. Wainwright,Nicholas W.J. Wainwright,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,Tom Wilsgaard,James F. Wilson,Elizabeth H. Young,Elizabeth H. Young,Jing Hua Zhao,Linda S. Adair,Dominique Arveiler,Themistocles L. Assimes,Stefania Bandinelli,Franklyn I. Bennett,Murielle Bochud,Bernhard O. Boehm,Bernhard O. Boehm,Dorret I. Boomsma,Ingrid B. Borecki,Stefan R. Bornstein,Pascal Bovet,Michel Burnier,Harry Campbell,Aravinda Chakravarti,John C. Chambers,John C. Chambers,John C. Chambers,Yii-Der Ida Chen,Yii-Der Ida Chen,Francis S. Collins,Richard S. Cooper,John Danesh,George Dedoussis,Ulf de Faire,Alan B. Feranil,Jean Ferrières,Luigi Ferrucci,Nelson B. Freimer,Christian Gieger,Leif Groop,Leif Groop,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Aroon D. Hingorani,Joel N. Hirschhorn,Joel N. Hirschhorn,Albert Hofman,G. Kees Hovingh,Chao A. Hsiung,Steve E. Humphries,Steven C. Hunt,Kristian Hveem,Carlos Iribarren,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Antti Jula,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Antero Kesäniemi,Mika Kivimäki,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Peter J. Koudstaal,Ronald M. Krauss,Diana Kuh,Johanna Kuusisto,Kirsten Ohm Kyvik,Markku Laakso,Timo A. Lakka,Timo A. Lakka,Lars Lind,Cecilia M. Lindgren,Nicholas G. Martin,Winfried März,Winfried März,Winfried März,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Andres Metspalu,Leena Moilanen,Andrew D. Morris,Patricia B. Munroe,Inger Njølstad,Nancy L. Pedersen,Chris Power,Peter P. Pramstaller,Peter P. Pramstaller,Jackie F. Price,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Rainer Rauramaa,Rainer Rauramaa,Danish Saleheen,Danish Saleheen,Veikko Salomaa,Dharambir K. Sanghera,Jouko Saramies,Peter Schwarz,Wayne Huey-Herng Sheu,Alan R. Shuldiner,Alan R. Shuldiner,Agneta Siegbahn,Tim D. Spector,Kari Stefansson,Kari Stefansson,David P. Strachan,Bamidele O. Tayo,Elena Tremoli,Jaakko Tuomilehto,Matti Uusitupa,Cornelia M. van Duijn,Peter Vollenweider,Lars Wallentin,Nicholas J. Wareham,John Whitfield,Bruce H. R. Wolffenbuttel,Jose M. Ordovas,Jose M. Ordovas,Eric Boerwinkle,Colin N. A. Palmer,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Daniel I. Chasman,Jerome I. Rotter,Paul W. Franks,Paul W. Franks,Paul W. Franks,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,L. Adrienne Cupples,L. Adrienne Cupples,Manjinder S. Sandhu,Manjinder S. Sandhu,Stephen S. Rich,Michael Boehnke,Panos Deloukas,Sekar Kathiresan,Sekar Kathiresan,Karen L. Mohlke,Erik Ingelsson,Erik Ingelsson,Gonçalo R. Abecasis +319 more
TL;DR: It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index.
Journal ArticleDOI
Common variants associated with plasma triglycerides and risk for coronary artery disease
Ron Do,Cristen J. Willer,Ellen M. Schmidt,Sebanti Sengupta,Chi Gao,Gina M. Peloso,Stefan Gustafsson,Stavroula Kanoni,Andrea Ganna,Jin Chen,Martin L. Buchkovich,Samia Mora,Jacques S. Beckmann,Jennifer L. Bragg-Gresham,Hsing-Yi Chang,Ayse Demirkan,Heleen M. den Hertog,Louise A. Donnelly,Georg Ehret,Tõnu Esko,Mary F. Feitosa,Teresa Ferreira,Krista Fischer,Pierre Fontanillas,Ross M. Fraser,Daniel F. Freitag,Deepti Gurdasani,Kauko Heikkilä,Elina Hyppönen,Aaron Isaacs,Anne U. Jackson,Åsa Johansson,Toby Johnson,Marika Kaakinen,Johannes Kettunen,Johannes Kettunen,Marcus E. Kleber,Xiaohui Li,Jian'an Luan,Leo-Pekka Lyytikäinen,Patrik K. E. Magnusson,Massimo Mangino,Evelin Mihailov,May E. Montasser,Martina Müller-Nurasyid,Ilja M. Nolte,Jeffrey R. O'Connell,Cameron D. Palmer,Markus Perola,Ann-Kristin Petersen,Serena Sanna,Richa Saxena,Sonia Shah,Dmitry Shungin,Carlo Sidore,Ci Song,Rona J. Strawbridge,Ida Surakka,Ida Surakka,Toshiko Tanaka,Tanya M. Teslovich,Gudmar Thorleifsson,Evita G. Van Den Herik,Benjamin F. Voight,Kelly A. Volcik,Lindsay L. Waite,Andrew Wong,Ying Wu,Weihua Zhang,Devin Absher,Gershim Asiki,Inês Barroso,Latonya F. Been,Jennifer L. Bolton,Lori L. Bonnycastle,Paolo Brambilla,Mary Susan Burnett,Giancarlo Cesana,Maria Dimitriou,Alex S. F. Doney,Angela Döring,Paul Elliott,Stephen E. Epstein,Gudmundur I. Eyjolfsson,Bruna Gigante,Mark O. Goodarzi,Harald Grallert,Martha L. Gravito,Christopher J. Groves,Göran Hallmans,Anna-Liisa Hartikainen,Caroline Hayward,Dena G. Hernandez,Andrew A. Hicks,Hilma Holm,Yi Jen Hung,Thomas Illig,Matthew Jones,Pontiano Kaleebu,John J.P. Kastelein,Kay-Tee Khaw,Eric Kim,Norman Klopp,Pirjo Komulainen,Meena Kumari,Claudia Langenberg,Terho Lehtimäki,Shih-Yi Lin,Jaana Lindström,Ruth J. F. Loos,François Mach,Wendy L. McArdle,Christa Meisinger,Braxton D. Mitchell,Gabrielle Müller,Ramaiah Nagaraja,Narisu Narisu,Tuomo Nieminen,Rebecca N. Nsubuga,Isleifur Olafsson,Ken K. Ong,Aarno Palotie,Theodore Papamarkou,Cristina Pomilla,Anneli Pouta,Anneli Pouta,Daniel J. Rader,Muredach P. Reilly,Paul M. Ridker,Fernando Rivadeneira,Igor Rudan,Aimo Ruokonen,Nilesh J. Samani,Hubert Scharnagl,Janet Seeley,Kaisa Silander,Kaisa Silander,Alena Stančáková,Kathleen Stirrups,Amy J. Swift,Laurence Tiret,André G. Uitterlinden,L. Joost van Pelt,Sailaja Vedantam,Nicholas W.J. Wainwright,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,Tom Wilsgaard,James F. Wilson,Elizabeth H. Young,Jing Hua Zhao,Linda S. Adair,Dominique Arveiler,Themistocles L. Assimes,Stefania Bandinelli,Franklyn I. Bennett,Murielle Bochud,Bernhard O. Boehm,Dorret I. Boomsma,Ingrid B. Borecki,Stefan R. Bornstein,Pascal Bovet,Michel Burnier,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Yii-Der Ida Chen,Francis S. Collins,Richard S. Cooper,John Danesh,George Dedoussis,Ulf de Faire,Alan B. Feranil,Jean Ferrières,Luigi Ferrucci,Nelson B. Freimer,Christian Gieger,Leif Groop,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Aroon D. Hingorani,Joel N. Hirschhorn,Albert Hofman,G. Kees Hovingh,Chao A. Hsiung,Steve E. Humphries,Steven C. Hunt,Kristian Hveem,Carlos Iribarren,Marjo-Riitta Järvelin,Antti Jula,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Antero Kesäniemi,Mika Kivimäki,Jaspal S. Kooner,Peter J. Koudstaal,Ronald M. Krauss,Diana Kuh,Johanna Kuusisto,Kirsten Ohm Kyvik,Markku Laakso,Timo A. Lakka,Lars Lind,Cecilia M. Lindgren,Nicholas G. Martin,Winfried März,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Andres Metspalu,Leena Moilanen,Andrew D. Morris,Patricia B. Munroe,Inger Njølstad,Nancy L. Pedersen,Chris Power,Peter P. Pramstaller,Jackie F. Price,Bruce M. Psaty,Thomas Quertermous,Rainer Rauramaa,Danish Saleheen,Veikko Salomaa,Dharambir K. Sanghera,Jouko Saramies,Peter Schwarz,Wayne Huey-Herng Sheu,Alan R. Shuldiner,Agneta Siegbahn,Tim D. Spector,Kari Stefansson,David P. Strachan,Bamidele O. Tayo,Elena Tremoli,Jaakko Tuomilehto,Matti Uusitupa,Cornelia M. van Duijn,Peter Vollenweider,Lars Wallentin,Nicholas J. Wareham,John Whitfield,Bruce H. R. Wolffenbuttel,David Altshuler,Jose M. Ordovas,Eric Boerwinkle,Colin N. A. Palmer,Unnur Thorsteinsdottir,Daniel I. Chasman,Jerome I. Rotter,Paul W. Franks,Samuli Ripatti,L. Adrienne Cupples,Manjinder S. Sandhu,Stephen S. Rich,Michael Boehnke,Panos Deloukas,Karen L. Mohlke,Erik Ingelsson,Gonçalo R. Abecasis,Mark J. Daly,Benjamin M. Neale,Sekar Kathiresan +266 more
TL;DR: It is suggested that triglyceride-rich lipoproteins causally influence risk for CAD, and the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk.
Journal ArticleDOI
PhenoScanner: a database of human genotype-phenotype associations.
James R Staley,James A. Blackshaw,Mihir A Kamat,Steve Ellis,Praveen Surendran,Benjamin B. Sun,Dirk S. Paul,Daniel F. Freitag,Stephen Burgess,John Danesh,Robin Young,Adam S. Butterworth +11 more
TL;DR: PhenoScanner is a curated database of publicly available results from large-scale genetic association studies that aims to facilitate ‘phenome scans’, the cross-referencing of genetic variants with many phenotypes, to help aid understanding of disease pathways and biology.
Journal ArticleDOI
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Nadeem Sarwar,Adam S. Butterworth,Daniel F. Freitag,John Gregson,Peter Willeit,Donal Gorman,Pei Gao,Danish Saleheen,Augusto Rendon,Christopher P. Nelson,Peter S. Braund,Alistair S. Hall,Daniel I. Chasman,Anne Tybjærg-Hansen,John C. Chambers,Emelia J. Benjamin,Paul W. Franks,Robert Clarke,Arthur A. M. Wilde,Mieke D. Trip,Maristella Steri,Jacqueline C. M. Witteman,Lu Qi,C. Ellen van der Schoot,Ulf de Faire,Jeanette Erdmann,Heather M. Stringham,Wolfgang Koenig,Daniel J. Rader,David Melzer,David Reich,Bruce M. Psaty,Marcus E. Kleber,Demosthenes B. Panagiotakos,Johann Willeit,Patrik Wennberg,Mark Woodward,Svetlana Adamovic,Eric B. Rimm,Tom W. Meade,Richard F. Gillum,Jonathan A. Shaffer,Albert Hofman,Altan Onat,Johan Sundström,S. Wassertheil-Smoller,Dan Mellström,John Gallacher,Mary Cushman,Russell P. Tracy,Jussi Kauhanen,Magnus Karlsson,Jukka T. Salonen,Lars Wilhelmsen,Philippe Amouyel,Bernard Cantin,Lyle G. Best,Yoav Ben-Shlomo,JoAnn E. Manson,George Davey-Smith,Paul I.W. de Bakker,Christopher J. O'Donnell,James F. Wilson,Anthony G. Wilson,Themistocles L. Assimes,John-Olov Jansson,Claes Ohlsson,Åsa Tivesten,Östen Ljunggren,Muredach P. Reilly,Anders Hamsten,Erik Ingelsson,François Cambien,Joseph Hung,G. Neil Thomas,Michael Boehnke,Heribert Schunkert,Folkert W. Asselbergs,John J.P. Kastelein,Vilmundur Gudnason,Veikko Salomaa,Tamara B. Harris,Jaspal S. Kooner,Kristine H. Allin,Kristine H. Allin,Børge G. Nordestgaard,Jemma C. Hopewell,Alison H. Goodall,Paul M. Ridker,Hilma Holm,Hugh Watkins,Willem H. Ouwehand,Nilesh J. Samani,Stephen Kaptoge,Emanuele Di Angelantonio,Olivier Harari,John Danesh +96 more
TL;DR: In this article, a functional genetic variant known to affect IL6R signalling was studied to assess whether this pathway is causally relevant to coronary heart disease, and Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking.
Journal ArticleDOI
Association of Cardiometabolic Multimorbidity With Mortality
Emanuele Di Angelantonio,Stephen Kaptoge,David Wormser,Peter Willeit,Adam S. Butterworth,Narinder Bansal,Linda M. O’Keeffe,Pei Gao,Angela M. Wood,Stephen Burgess,Daniel F. Freitag,Lisa Pennells,Sanne A.E. Peters,Carole L. Hart,Lise Lund Håheim,Richard F. Gillum,Børge G. Nordestgaard,Bruce M. Psaty,Bu B. Yeap,Matthew Knuiman,Paul J. Nietert,Jussi Kauhanen,Jukka T. Salonen,Lewis H. Kuller,Leon A. Simons,Yvonne T. van der Schouw,Elizabeth Barrett-Connor,Randi Selmer,Carlos J. Crespo,Beatriz L. Rodriguez,W. M. Monique Verschuren,Veikko Salomaa,Kurt Svärdsudd,Pim van der Harst,Cecilia Björkelund,Lars Wilhelmsen,Robert B. Wallace,Hermann Brenner,Philippe Amouyel,Elizabeth L M Barr,Hiroyasu Iso,Altan Onat,Maurizio Trevisan,Ralph B. D'Agostino,Cyrus Cooper,Cyrus Cooper,Maryam Kavousi,Lennart Welin,Ronan Roussel,Ronan Roussel,Frank B. Hu,Shinichi Sato,Karina W. Davidson,Barbara V. Howard,Maarten J.G. Leening,Annika Rosengren,Marcus Dörr,Dorly J. H. Deeg,Stefan Kiechl,Coen D.A. Stehouwer,Aulikki Nissinen,Simona Giampaoli,Chiara Donfrancesco,Daan Kromhout,Jackie F. Price,Annette Peters,Tom W. Meade,Edoardo Casiglia,Debbie A Lawlor,John Gallacher,Dorothea Nagel,Oscar H. Franco,Gerd Assmann,Gilles R. Dagenais,J. Wouter Jukema,Johan Sundström,Mark Woodward,Eric J. Brunner,Kay-Tee Khaw,Nicholas J. Wareham,Eric A. Whitsel,Inger Njølstad,Bo Hedblad,Sylvia Wassertheil-Smoller,Gunnar Engström,Wayne D. Rosamond,Elizabeth Selvin,Naveed Sattar,Simon G. Thompson,John Danesh +89 more
TL;DR: Because any combination of these conditions was associated with multiplicative mortality risk, life expectancy was substantially lower in people with multimorbidity.