Mary Devlin

TL;DR: The construction of human Fab libraries having a unique combination of immunoglobulin sequences captured from human donors and synthetic diversity in key antigen contact sites in heavy-chain complementarity-determining regions 1 and 2 are reported.

TL;DR: The discovery of ACE2 peptide inhibitors through selection of constrained peptide libraries displayed on phage demonstrates that library selection by phage display technology can be a rapid and efficient way to discover potent and specific protease inhibitors.

TL;DR: The technology allows the generation and production of antigen-specific complete human antibodies as fast or even faster than raising monoclonal antibodies by conventional hybridoma techniques.

TL;DR: Several phage isolates that bind specifically to human serum albumin were isolated from disulfide‐constrained cyclic peptide phage‐display libraries and one of the highest affinity peptides, DX‐236, also bound well to several mammalian serum albumins (SA).

TL;DR: A novel and general way of generating high affinity peptide (HAP) binders to receptor tyrosine kinases (RTKs) using a multi-step process comprising phage-display selection, identification of peptide pairs suitable for hetero-dimerization and chemical synthesis of heterodimers is described.