M
Mary Devlin
Publications - 8
Citations - 868
Mary Devlin is an academic researcher. The author has contributed to research in topics: Phage display & Peptide. The author has an hindex of 6, co-authored 8 publications receiving 819 citations.
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Journal ArticleDOI
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
Rene Hoet,Edward H. Cohen,Rachel Baribault Kent,Kristin L. Rookey,Sonia Schoonbroodt,Shannon Hogan,Louise Rem,Nicolas Frans,Marc Daukandt,Henk Pieters,Rob van Hegelsom,Nicole Coolen-van Neer,Nastri Horacio G,Isaac J. Rondon,Jennifer A. Leeds,Simon E. Hufton,Lili Huang,Irina Kashin,Mary Devlin,Guannan Kuang,Mieke Steukers,Malini Viswanathan,Andrew E. Nixon,Daniel J. Sexton,Hennie R. Hoogenboom,Robert Charles Ladner +25 more
TL;DR: The construction of human Fab libraries having a unique combination of immunoglobulin sequences captured from human donors and synthetic diversity in key antigen contact sites in heavy-chain complementarity-determining regions 1 and 2 are reported.
Journal ArticleDOI
Novel Peptide Inhibitors of Angiotensin-converting Enzyme 2 *
Lili Huang,Daniel J. Sexton,Kirsten Skogerson,Mary Devlin,Rodger Smith,Indra Sanyal,Tom J. Parry,Rachel Baribault Kent,Jasmin Enright,Qi-Long Wu,Greg Conley,Daniel B. DeOliveira,Lee A. Morganelli,Matthew D. Ducar,Charles R. Wescott,Robert Charles Ladner +15 more
TL;DR: The discovery of ACE2 peptide inhibitors through selection of constrained peptide libraries displayed on phage demonstrates that library selection by phage display technology can be a rapid and efficient way to discover potent and specific protease inhibitors.
Journal ArticleDOI
Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries
Thomas Jostock,Marc Vanhove,Eddy Brepoels,Rein van Gool,Marc Daukandt,Anita Wehnert,Rob van Hegelsom,Dan Dransfield,Daniel J. Sexton,Mary Devlin,Art Ley,Jürgen Müllberg +11 more
TL;DR: The technology allows the generation and production of antigen-specific complete human antibodies as fast or even faster than raising monoclonal antibodies by conventional hybridoma techniques.
Journal ArticleDOI
Development of mammalian serum albumin affinity purification media by peptide phage display.
Aaron K. Sato,Daniel J. Sexton,Lee A. Morganelli,Edward H. Cohen,Qi Long Wu,Greg Conley,Zoya Streltsova,Stan W. Lee,Mary Devlin,Daniel B. DeOliveira,Jasmin Enright,Rachel Baribault Kent,Charles R. Wescott,Tom C. Ransohoff,Arthur C. Ley,Robert Charles Ladner +15 more
TL;DR: Several phage isolates that bind specifically to human serum albumin were isolated from disulfide‐constrained cyclic peptide phage‐display libraries and one of the highest affinity peptides, DX‐236, also bound well to several mammalian serum albumins (SA).
Journal ArticleDOI
A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases
A. Shrivastava,M.A. von Wronski,Aaron K. Sato,Daniel T. Dransfield,Daniel J. Sexton,Nancy J. Bogdan,Radhakrishna Pillai,P. Nanjappan,Bo Song,E. Marinelli,Daniel B. DeOliveira,C. Luneau,Mary Devlin,A. Muruganandam,A. Abujoub,G. Connelly,Q.L. Wu,Greg Conley,Q. Chang,Michael F. Tweedle,Robert C. Ladner,Rolf E Swenson,Adrian D. Nunn +22 more
TL;DR: A novel and general way of generating high affinity peptide (HAP) binders to receptor tyrosine kinases (RTKs) using a multi-step process comprising phage-display selection, identification of peptide pairs suitable for hetero-dimerization and chemical synthesis of heterodimers is described.