J
Jun Zhong
Researcher at Johns Hopkins University
Publications - 45
Citations - 6417
Jun Zhong is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Phosphorylation & Signal transduction. The author has an hindex of 29, co-authored 41 publications receiving 5708 citations. Previous affiliations of Jun Zhong include Nanjing University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A draft map of the human proteome
Min-Sik Kim,Sneha M. Pinto,Derese Getnet,Raja Sekhar Nirujogi,Srikanth S. Manda,Raghothama Chaerkady,Anil K. Madugundu,Dhanashree S. Kelkar,Ruth Isserlin,Shobhit Jain,Joji Kurian Thomas,Babylakshmi Muthusamy,Pamela Leal-Rojas,Pamela Leal-Rojas,Praveen Kumar,Nandini A. Sahasrabuddhe,Lavanya Balakrishnan,Jayshree Advani,Bijesh George,Santosh Renuse,Lakshmi Dhevi N. Selvan,Arun H. Patil,Vishalakshi Nanjappa,Aneesha Radhakrishnan,Samarjeet Prasad,Tejaswini Subbannayya,Rajesh Raju,Manish Kumar,Sreelakshmi K. Sreenivasamurthy,Arivusudar Marimuthu,Gajanan Sathe,Sandip Chavan,Keshava K. Datta,Yashwanth Subbannayya,Apeksha Sahu,Soujanya D. Yelamanchi,Savita Jayaram,Pavithra Rajagopalan,Jyoti Sharma,Krishna R Murthy,Nazia Syed,Renu Goel,Aafaque Ahmad Khan,Sartaj Ahmad,Gourav Dey,Keshav Mudgal,Aditi Chatterjee,Tai-Chung Huang,Jun Zhong,Xinyan Wu,Patrick G. Shaw,Donald Freed,Muhammad Saddiq Zahari,Kanchan K Mukherjee,Subramanian Shankar,Anita Mahadevan,Henry H N Lam,Chris J. Mitchell,Susarla K. Shankar,Parthasarathy Satishchandra,John T. Schroeder,Ravi Sirdeshmukh,Anirban Maitra,Steven D. Leach,Charles G. Drake,Marc K. Halushka,T. S. Keshava Prasad,Ralph H. Hruban,Candace L. Kerr,Candace L. Kerr,Gary D. Bader,Christine A. Iacobuzio-Donahue,Harsha Gowda,Akhilesh Pandey +73 more
TL;DR: A draft map of the human proteome is presented using high-resolution Fourier-transform mass spectrometry to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-c coding RNAs and upstream open reading frames.
Journal ArticleDOI
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Weibo Luo,Hongxia Hu,Ryan Chang,Jun Zhong,Matthew K. Knabel,Robert N. O'Meally,Robert N. Cole,Akhilesh Pandey,Gregg L. Semenza +8 more
TL;DR: In this article, the pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM 2 gene, and they are activated by hypoxia-inducible factor 1 (HIF-1).
Journal ArticleDOI
Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets
Tejal K. Gandhi,Jun Zhong,Suresh Mathivanan,L. Karthick,K N Chandrika,Subburaman Mohan,Salil Sharma,Stefan Pinkert,Shilpa Nagaraju,Balamurugan Periaswamy,Goparani Mishra,Kannabiran Nandakumar,Beiyi Shen,Nandan P. Deshpande,Rashmi Nayak,Malabika Sarker,Jef D. Boeke,Giovanni Parmigiani,Jörg Schultz,Joel S. Bader,Akhilesh Pandey +20 more
TL;DR: The human interaction map constructed from the first analysis of the human proteome should facilitate an integrative systems biology approach to elucidating the cellular networks that contribute to health and disease states.
Journal ArticleDOI
NetPath: a public resource of curated signal transduction pathways
Kumaran Kandasamy,Subburaman Mohan,Rajesh Raju,Shivakumar Keerthikumar,Ghantasala S. Sameer Kumar,Abhilash K. Venugopal,Deepthi Telikicherla,Daniel J. Navarro,Suresh Mathivanan,Christian Pecquet,Sashi Kanth Gollapudi,Sudhir Gopal Tattikota,Shyam Mohan,Hariprasad Padhukasahasram,Yashwanth Subbannayya,Renu Goel,Harrys K.C. Jacob,Jun Zhong,Raja Sekhar,Vishalakshi Nanjappa,Lavanya Balakrishnan,Roopashree Subbaiah,Y. L. Ramachandra,B. Abdul Rahiman,T. S. Keshava Prasad,Jian Xin Lin,Jon C. D. Houtman,Stephen Desiderio,Jean-Christophe Renauld,Stefan N. Constantinescu,Osamu Ohara,Toshio Hirano,Masato Kubo,S. Singh,Purvesh Khatri,Sorin Draghici,Gary D. Bader,Gary D. Bader,Chris Sander,Warren J. Leonard,Akhilesh Pandey +40 more
TL;DR: NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles.
Journal ArticleDOI
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Ian Martin,Jungwoo Wren Kim,Byoung Dae Lee,Ho Chul Kang,Jinchong Xu,Hao Jia,Jeannette N. Stankowski,Min-Sik Kim,Jun Zhong,Manoj Kumar,Shaida A. Andrabi,Yulan Xiong,Dennis W. Dickson,Zbigniew K. Wszolek,Akhilesh Pandey,Ted M. Dawson,Valina L. Dawson +16 more
TL;DR: It is shown that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron PD models and can be prevented by phosphodeficient T136A s15, revealing a novel mechanism of PD pathogenesis linked to elevated L RRK2 kinase activity and aberrant protein synthesis in vivo.