Showing papers by "Massimo Antonelli published in 2012"
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University of Toronto1, Guy's and St Thomas' NHS Foundation Trust2, Catholic University of the Sacred Heart3, University of Texas at Austin4, University of Geneva5, Johns Hopkins University6, University of Milan7, St George’s University Hospitals NHS Foundation Trust8, Université libre de Bruxelles9, Harvard University10, University of Turin11
TL;DR: This panel addressed some of the limitations of the prior ARDS definition by incorporating current data, physiologic concepts, and clinical trials results to develop the Berlin definition, which should facilitate case recognition and better match treatment options to severity in both research trials and clinical practice.
Abstract: Our objective was to revise the definition of acute respiratory distress syndrome (ARDS) using a conceptual model incorporating reliability and validity, and a novel iterative approach with formal evaluation of the definition. The European Society of Intensive Care Medicine identified three chairs with broad expertise in ARDS who selected the participants and created the agenda. After 2 days of consensus discussions a draft definition was developed, which then underwent empiric evaluation followed by consensus revision. The Berlin Definition of ARDS maintains a link to prior definitions with diagnostic criteria of timing, chest imaging, origin of edema, and hypoxemia. Patients may have ARDS if the onset is within 1 week of a known clinical insult or new/worsening respiratory symptoms. For the bilateral opacities on chest radiograph criterion, a reference set of chest radiographs has been developed to enhance inter-observer reliability. The pulmonary artery wedge pressure criterion for hydrostatic edema was removed, and illustrative vignettes were created to guide judgments about the primary cause of respiratory failure. If no risk factor for ARDS is apparent, however, objective evaluation (e.g., echocardiography) is required to help rule out hydrostatic edema. A minimum level of positive end-expiratory pressure and mutually exclusive PaO2/FiO2 thresholds were chosen for the different levels of ARDS severity (mild, moderate, severe) to better categorize patients with different outcomes and potential responses to therapy. This panel addressed some of the limitations of the prior ARDS definition by incorporating current data, physiologic concepts, and clinical trials results to develop the Berlin definition, which should facilitate case recognition and better match treatment options to severity in both research trials and clinical practice.
1,074 citations
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TL;DR: In this paper, a Fourier analysis of the charged particle pair distribution in relative azimuthal angle (Delta phi = phi(a)-phi(b)) is performed to extract the coefficients v(n,n) =.
Abstract: Differential measurements of charged particle azimuthal anisotropy are presented for lead-lead collisions at root sNN = 2.76 TeV with the ATLAS detector at the LHC, based on an integrated luminosity of approximately 8 mu b(-1). This anisotropy is characterized via a Fourier expansion of the distribution of charged particles in azimuthal angle relative to the reaction plane, with the coefficients v(n) denoting the magnitude of the anisotropy. Significant v(2)-v(6) values are obtained as a function of transverse momentum (0.5 = 3 are found to vary weakly with both eta and centrality, and their p(T) dependencies are found to follow an approximate scaling relation, v(n)(1/n)(p(T)) proportional to v(2)(1/2)(p(T)), except in the top 5% most central collisions. A Fourier analysis of the charged particle pair distribution in relative azimuthal angle (Delta phi = phi(a)-phi(b)) is performed to extract the coefficients v(n,n) = . For pairs of charged particles with a large pseudorapidity gap (|Delta eta = eta(a) - eta(b)| > 2) and one particle with p(T) < 3 GeV, the v(2,2)-v(6,6) values are found to factorize as v(n,n)(p(T)(a), p(T)(b)) approximate to v(n) (p(T)(a))v(n)(p(T)(b)) in central and midcentral events. Such factorization suggests that these values of v(2,2)-v(6,6) are primarily attributable to the response of the created matter to the fluctuations in the geometry of the initial state. A detailed study shows that the v(1,1)(p(T)(a), p(T)(b)) data are consistent with the combined contributions from a rapidity-even v(1) and global momentum conservation. A two-component fit is used to extract the v(1) contribution. The extracted v(1) isobserved to cross zero at pT approximate to 1.0 GeV, reaches a maximum at 4-5 GeV with a value comparable to that for v(3), and decreases at higher p(T).
435 citations
01 Feb 2012
352 citations
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National and Kapodistrian University of Athens1, Alberta Health Services2, Paris Descartes University3, Istanbul University4, China Medical University (PRC)5, University Hospital of Lausanne6, Utrecht University7, Semmelweis University8, Poznan University of Medical Sciences9, Royal Brisbane and Women's Hospital10, Ghent University Hospital11, Hebron University12
TL;DR: Intensified efforts to prevent HA-BSIs and to optimize their management through adequate source control and antibiotic therapy are needed to improve outcomes.
Abstract: The recent increase in drug-resistant micro-organisms complicates the management of hospital-acquired bloodstream infections (HA-BSIs). We investigated the epidemiology of HA-BSI and evaluated the impact of drug resistance on outcomes of critically ill patients, controlling for patient characteristics and infection management. A prospective, multicentre non-representative cohort study was conducted in 162 intensive care units (ICUs) in 24 countries. We included 1,156 patients [mean ± standard deviation (SD) age, 59.5 ± 17.7 years; 65 % males; mean ± SD Simplified Acute Physiology Score (SAPS) II score, 50 ± 17] with HA-BSIs, of which 76 % were ICU-acquired. Median time to diagnosis was 14 [interquartile range (IQR), 7–26] days after hospital admission. Polymicrobial infections accounted for 12 % of cases. Among monomicrobial infections, 58.3 % were gram-negative, 32.8 % gram-positive, 7.8 % fungal and 1.2 % due to strict anaerobes. Overall, 629 (47.8 %) isolates were multidrug-resistant (MDR), including 270 (20.5 %) extensively resistant (XDR), and 5 (0.4 %) pan-drug-resistant (PDR). Micro-organism distribution and MDR occurrence varied significantly (p < 0.001) by country. The 28-day all-cause fatality rate was 36 %. In the multivariable model including micro-organism, patient and centre variables, independent predictors of 28-day mortality included MDR isolate [odds ratio (OR), 1.49; 95 % confidence interval (95 %CI), 1.07–2.06], uncontrolled infection source (OR, 5.86; 95 %CI, 2.5–13.9) and timing to adequate treatment (before day 6 since blood culture collection versus never, OR, 0.38; 95 %CI, 0.23–0.63; since day 6 versus never, OR, 0.20; 95 %CI, 0.08–0.47). MDR and XDR bacteria (especially gram-negative) are common in HA-BSIs in critically ill patients and are associated with increased 28-day mortality. Intensified efforts to prevent HA-BSIs and to optimize their management through adequate source control and antibiotic therapy are needed to improve outcomes.
314 citations
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TL;DR: In this article, the authors describe the measurement of elliptic flow of charged particles in lead-lead collisions at root s(NN) = 2.76 TeV using the ATLAS detector at the Large Hadron Collider (LHC).
265 citations
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TL;DR: In this paper, the production cross sections of the inclusive Drell-Yan processes W-+/- -> l nu and Z/gamma* -> ll (l = e, mu) are measured in proton-proton collisions at root s = 7 TeV with the ATLAS detector.
Abstract: The production cross sections of the inclusive Drell-Yan processes W-+/- -> l nu and Z/gamma* -> ll (l = e, mu) are measured in proton-proton collisions at root s = 7 TeV with the ATLAS detector. The cross sections are reported integrated over a fiducial kinematic range, extrapolated to the full range, and also evaluated differentially as a function of the W decay lepton pseudorapidity and the Z boson rapidity, respectively. Based on an integrated luminosity of about 35 pb(-1) collected in 2010, the precision of these measurements reaches a few percent. The integrated and the differential W-+/- and Z/gamma* cross sections in the e and mu channels are combined, and compared with perturbative QCD calculations, based on a number of different parton distribution sets available at next-to-next-to-leading order.
250 citations
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TL;DR: In this article, the authors used the ATLAS detector at the Large Hadron Collider (LHC) to measure inclusive jet and dijet cross sections in proton-proton collisions at a centre-of-mass energy of 7 TeV using the anti-kT algorithm.
Abstract: Inclusive jet and dijet cross sections have been measured in proton-proton collisions at a centre-of-mass energy of 7 TeV using the ATLAS detector at the Large Hadron Collider. The cross sections were measured using jets clustered with the anti-kT algorithm with parameters R=0.4 and R=0.6. These measurements are based on the 2010 data sample, consisting of a total integrated luminosity of 37 inverse picobarns. Inclusive jet double-differential cross sections are presented as a function of jet transverse momentum, in bins of jet rapidity. Dijet double-differential cross sections are studied as a function of the dijet invariant mass, in bins of half the rapidity separation of the two leading jets. The measurements are performed in the jet rapidity range |y|<4.4, covering jet transverse momenta from 20 GeV to 1.5 TeV and dijet invariant masses from 70 GeV to 5 TeV. The data are compared to expectations based on next-to-leading order QCD calculations corrected for non-perturbative effects, as well as to next-to-leading order Monte Carlo predictions. In addition to a test of the theory in a new kinematic regime, the data also provide sensitivity to parton distribution functions in a region where they are currently not well-constrained.
230 citations
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TL;DR: In this article, a search for the standard model Higgs boson is performed in the diphoton decay channel, and the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations.
Abstract: A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV.
212 citations
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TL;DR: In this paper, a QCD analysis of ATLAS data on inclusive W-+/- and Z boson production in pp collisions at the LHC, jointly with ep deep-inelastic scattering data from HERA, is reported.
Abstract: AQCD analysis is reported of ATLAS data on inclusive W-+/- and Z boson production in pp collisions at the LHC, jointly with ep deep-inelastic scattering data from HERA. The ATLAS data exhibit sensitivity to the light quark sea composition and magnitude at Bjorken x similar to 0:01. Specifically, the data support the hypothesis of a symmetric composition of the light quark sea at low x. The ratio of the strange-to-down sea quark distributions is determined to be 1:00(-0:28)(+0.25) at absolute four-momentum transfer squared Q(2) = 1: 9 GeV2 and x = 0: 023.
154 citations
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TL;DR: In this article, the internal substructure of jets generated by QCD radiation is tested on an inclusive sample of jets recorded with the ATLAS detector in 2010, which corresponds to 35 pb(-1) of pp collisions delivered by the LHC at root s = 7 TeV.
Abstract: Recent studies have highlighted the potential of jet substructure techniques to identify the hadronic decays of boosted heavy particles. These studies all rely upon the assumption that the internal substructure of jets generated by QCD radiation is well understood. In this article, this assumption is tested on an inclusive sample of jets recorded with the ATLAS detector in 2010, which corresponds to 35 pb(-1) of pp collisions delivered by the LHC at root s = 7 TeV. In a subsample of events with single pp collisions, measurements corrected for detector efficiency and resolution are presented with full systematic uncertainties. Jet invariant mass, k(t) splitting scales and N-subjettiness variables are presented for anti-k(t) R = 1.0 jets and Cambridge-Aachen R = 1.2 jets. Jet invariant-mass spectra for Cambridge-Aachen R = 1.2 jets after a splitting and filtering procedure are also presented. Leading-order parton-shower Monte Carlo predictions for these variables are found to be broadly in agreement with data. The dependence of mean jet mass on additional pp interactions is also explored.
153 citations
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TL;DR: A combined search for the Standard Model Higgs boson with the ATLAS detector at the LHC is presented in this article, where the data sets used correspond to integrated luminosities from 4.6 fb (-1) to 4.9 fb(-1) of proton-proton collisions collected at root s = 7 TeV in 2011.
Abstract: A combined search for the Standard Model Higgs boson with the ATLAS detector at the LHC is presented. The data sets used correspond to integrated luminosities from 4.6 fb(-1) to 4.9 fb(-1) of proton-proton collisions collected at root s = 7 TeV in 2011. The Higgs boson mass ranges of 111.4 GeV to 116.6 GeV, 119.4 GeV to 122.1 GeV, and 129.2 GeV to 541 GeV are excluded at the 95% confidence level, while the range 120 GeV to 560 GeV is expected to be excluded in the absence of a signal. An excess of events is observed at Higgs boson mass hypotheses around 126 GeV with a local significance of 2.9 standard deviations (sigma). The global probability for the background to produce an excess at least as significant anywhere in the entire explored Higgs boson mass range of 110-600 GeV is estimated to be similar to 15%, corresponding to a significance of approximately 1 sigma.
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TL;DR: In this paper, an update of a search for supersymmetry in final states containing jets, missing transverse momentum, and one isolated electron or muon is presented, using 1.04 fb(-1) of proton-proton collision data at root s =7 TeV recorded by the ATLAS experiment at the LHC in the first half of 2011.
Abstract: We present an update of a search for supersymmetry in final states containing jets, missing transverse momentum, and one isolated electron or muon, using 1.04 fb(-1) of proton-proton collision data at root s =7 TeV recorded by the ATLAS experiment at the LHC in the first half of 2011. The analysis is carried out in four distinct signal regions with either three or four jets and variations on the (missing) transverse momentum cuts, resulting in optimized limits for various supersymmetry models. No excess above the standard model background expectation is observed. Limits are set on the visible cross section of new physics within the kinematic requirements of the search. The results are interpreted as limits on the parameters of the minimal supergravity framework, limits on cross sections of simplified models with specific squark and gluino decay modes, and limits on parameters of a model with bilinear R-parity violation.
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TL;DR: In this paper, a search for squarks and gluinos in events containing jets, missing transverse momentum and no electrons or muons is presented, and the data were recorded in 2011 by the ATLAS experiment in root s = 7 TeV proton-proton collisions at the Large Hadron Collider.
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TL;DR: The ATLAS experiment at the LHC has measured the centrality dependence of charged particle pseudorapidity distributions over vertical bar eta vertical bar < 2 in lead-lead collisions at a nucleo...
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TL;DR: In this paper, a measurement of the cross section of single top-quark production in the t-channel using 1.04 fb -1 of pp collision data at s=7 TeV recorded with the ATLAS detector at the LHC is presented.
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TL;DR: In this paper, the results of a search for charged Higgs bosons were presented based on 4.6/fb of proton-proton collision data at 7 TeV collected by the ATLAS experiment at the Large Hadron Collider.
Abstract: The results of a search for charged Higgs bosons are presented. The analysis is based on 4.6/fb of proton-proton collision data at sqrt(s) = 7 TeV collected by the ATLAS experiment at the Large Hadron Collider, using top quark pair events with a tau lepton in the final state. The data are consistent with the expected background from Standard Model processes. Assuming that the branching ratio of the charged Higgs boson to a tau lepton and a neutrino is 100%, this leads to upper limits on the branching ratio of top quark decays to a b quark and a charged Higgs boson between 5% and 1% for charged Higgs boson masses ranging from 90 GeV to 160 GeV, respectively. In the context of the mh-max scenario of the MSSM, tan(beta) above 12-26, as well as between 1 and 2-6, can be excluded for charged Higgs boson masses between 90 GeV and 150 GeV.
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TL;DR: In this article, a search for the Standard Model Higgs boson in the decay channel H = ZZ((*)) -> l(+)l(-)l(+)+l(')-, where l,l' = e or mu, using proton-proton collisions at root s = 7 TeV recorded with the ATLAS detector and corresponding to an integrated luminosity of 4.8 fb(-1).
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TL;DR: In this article, a measurement of jet activity in t (t) over bar events produced in proton-proton collisions at a centre-of-mass energy of 7 TeV is presented, using 2.05 fb(-1) of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider.
Abstract: A measurement of the jet activity in t (t) over bar events produced in proton-proton collisions at a centre-of-mass energy of 7 TeV is presented, using 2.05 fb(-1) of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. The t (t) over bar events are selected in the dilepton decay channel with two identified b-jets from the top quark decays. Events are vetoed if they contain an additional jet with transverse momentum above a threshold in a central rapidity interval. The fraction of events surviving the jet veto is presented as a function of this threshold for four different central rapidity interval definitions. An alternate measurement is also performed, in which events are vetoed if the scalar transverse momentum sum of the additional jets in each rapidity interval is above a threshold. In both measurements, the data are corrected for detector effects and compared to the theoretical models implemented in MC@NLO, POWHEG, ALPGEN and SHERPA. The experimental uncertainties are often smaller than the spread of theoretical predictions, allowing deviations between data and theory to be observed in some regions of phase space.
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TL;DR: In this paper, a search for hypothetical heavy neutrinos, N and right-handed gauge bosons, W-R, in events with high transverse momentum objects which include two reconstructed leptons and...
Abstract: This letter reports on a search for hypothetical heavy neutrinos, N, and right-handed gauge bosons, W-R, in events with high transverse momentum objects which include two reconstructed leptons and ...
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TL;DR: In this article, the mass distributions of jet pairs produced in LHC proton-proton collisions at a center-of-mass energy root s = 7 TeV were studied using a data set corresponding to an integrat...
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TL;DR: In this article, the authors presented evidence for the associated production of a W boson and a top quark using 2.05 fb(-1) of pp collision data at root s = 7 TeV accumulated with the ATLAS detector at the LHC.
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TL;DR: The χb(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider at √s=7 TeV and recorded by the ATLAS detector as mentioned in this paper.
Abstract: The χb(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider at √s=7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb-1, these states are reconstructed through their radiative decays to Υ(1S,2S) with Υ→μ+μ-. In addition to the mass peaks corresponding to the decay modes χb(1P,2P)→Υ(1S)γ, a new structure centered at a mass of 10.530±0.005(stat)±0.009(syst) GeV is also observed, in both the Υ(1S)γ and Υ(2S)γ decay modes. This structure is interpreted as the χb(3P) system.
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TL;DR: A measurement of the production cross-section for top quark pairs (t (t) over bar) in pp collisions at root s = 7 TeV is presented in this paper using data recorded with the ATLAS detector at the Large Hadron Co.
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TL;DR: It is concluded that ∆POP and PVI are equally effective for predicting fluid responsiveness in ventilated adult patients in sinus rhythm and prediction is more accurate when a large fluid bolus is administered.
Abstract: To systematically review the accuracy of the variation in pulse oxymetry plethysmographic waveform amplitude (∆POP) and the Pleth Variability Index (PVI) as predictors of fluid responsiveness in mechanically ventilated adults. MEDLINE, Scopus and the Cochrane Database of Systematic Reviews were screened for clinical studies in which the accuracy of ∆POP/PVI in predicting the hemodynamic response to a subsequent fluid bolus had been investigated. Random-effects meta-analysis was used to summarize the results. Data were stratified according to the amount of fluid bolus (large vs. small) and to the study index (∆POP vs. PVI). Ten studies in 233 patients were included in this meta-analysis. All patients were in normal sinus rhythm. The pooled area under the receiver operating characteristic curve (AUC) for identification of fluid responders was 0.85 [95 % confidence interval (CI) 0.79–0.92]. Pooled sensitivity and specificity were 0.80 (95 % CI 0.74–0.85) and 0.76 (0.68–0.82), respectively. No heterogeneity was found within studies with the same amount of fluid bolus, nor between studies on ∆POP and those on PVI. The AUC was significantly larger in studies with a large bolus amount than in those with a small bolus [0.92 (95 % CI 0.87–0.96) vs. 0.70 (0.62–0.79); p < 0.0001]. Sensitivity and specificity were also higher in studies with a large bolus [0.84 (95 % CI 0.77–0.90) vs. 0.72 (0.60–0.82) (small bolus), p = 0.08 and 0.86 (95 % CI 0.75–0.93) vs. 0.68 (0.56–0.77) (small bolus), p = 0.02], respectively. Based on our meta-analysis, we conclude that ∆POP and PVI are equally effective for predicting fluid responsiveness in ventilated adult patients in sinus rhythm. Prediction is more accurate when a large fluid bolus is administered.
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TL;DR: A search for direct pair production of supersymmetric top squarks (t(1)) is presented, assuming the t(1) decays into a top quark and the lightest supers asymmetric particle, χ(1)(0), and that both top quarks decay to purely hadronic final states.
Abstract: A search for direct pair production of supersymmetric top squarks ((t) over tilde (1)) is presented, assuming the (t) over tilde (1) decays into a top quark and the lightest supersymmetric particle, (chi) over tilde (0)(1), and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model background of 13.5(-3.6)(+3.7) (4.4(-1.3)(+1.7)) events in two signal regions based on integral Ldt = 4.7 fb(-1) of pp collision data taken at root s = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the (t) over tilde (1) versus (chi) over tilde (0)(1) mass plane is evaluated: 370 1) 10) similar to 0 GeV while m((t) over tilde1) = 445 GeV is excluded for m((chi) over tilde 10) <= 50 GeV.
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TL;DR: In this paper, a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb(-1) of pp collision data at root s = 7 TeV collected by the ATLAS experiment at the Large Hadron Collider in 2011, is presented.
Abstract: Results are presented of a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb(-1) of pp collision data at root s = 7 TeV collected by the ATLAS experiment at the Large Hadron Collider in 2011. The event selection requires missing transverse momentum, no isolated electrons or muons, and from >= 6 to >= 9 jets. No evidence is found for physics beyond the Standard Model. The results are interpreted in the context of a MSUGRA/CMSSM supersymmetric model, where, for large universal scalar mass m(0), gluino masses smaller than 840 GeV are excluded at the 95% confidence level, extending previously published limits. Within a simplified model containing only a gluino octet and a neutralino, gluino masses smaller than 870 GeV are similarly excluded for neutralino masses below 100 GeV.
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TL;DR: A measurement of spin correlation in t (t) over bar production is reported using data collected with the ATLAS detector at the LHC, corresponding to an integrated luminosity of 2.1 fb(-1) as discussed by the authors.
Abstract: A measurement of spin correlation in t (t) over bar production is reported using data collected with the ATLAS detector at the LHC, corresponding to an integrated luminosity of 2.1 fb(-1). Candidat ...
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TL;DR: In an R-parity conserving minimal supersymmetric scenario, assuming that the scalar bottom quarks decays exclusively into a bottom quark and a neutralino, 95% confidence-level upper limits are obtained in the b(1) - χ(1)(0) mass plane such that for neutralino masses below 60 GeV scalarBottom masses up to 390 GeV are excluded.
Abstract: The results of a search for pair production of the scalar partners of bottom quarks in 2: 05 fb(-1) of pp collisions at root s = 7 TeV using the ATLAS experiment are reported. Scalar bottom quarks ...
01 Oct 2012
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TL;DR: A blind analysis searching for the decay B-s(0) -> mu(+)mu(-) has been performed using proton-proton collisions at a centre-of-mass energy of 7 TeV recorded with the ATLAS detector at the LHC.