Mathias Leddin

TL;DR: Interestingly, pathway analysis of gene expression data revealed intriguing differences between MSCs suggesting that M SCs from UC and AM possess in general a higher potential of immunomodulatory capacity, whereas BM-MSCs showed aHigher potential of supporting regenerative processes as exemplified by neuronal differentiation and development.

TL;DR: Results establish that PU.1 mediates chromosome looping and functions as a master regulator of HSC proliferation and prevents excessive HSC division and exhaustion.

TL;DR: In this article, a combination of transgenic studies, global chromatin assays, and detailed molecular analyses is presented evidence that PU.1 is regulated by a novel mechanism involving cross talk between different cis elements together with lineage-restricted autoregulation.

TL;DR: It is shown here that the upstream regulatory cis element alone is insufficient to confer physiologic PU.1 expression in mice but requires the cooperation with other, previously unidentified elements.

TL;DR: An overview of the shared tasks and participants’ systems is provided to promote the community-driven development and evaluation of advanced natural language processing systems to detect, extract, and normalize health-related information in public, user-generated content.