Matthew A. Zurenski

TL;DR: A viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen.

TL;DR: It is shown that bacterial translocation and increased interleukin-6 production, resulting from dysfunction of the small-intestinal barrier, are critical for the development of PMP in mice that lack Tet2 expression in haematopoietic cells.

TL;DR: This work identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation.

TL;DR: A mouse model that reproduces the overexpression of IL-15 in the gut epithelium and lamina propria that is characteristic of active coeliac disease, expresses the predisposing HLA-DQ8 molecule, and develops villous atrophy after ingestion of gluten is described.

TL;DR: The role of neutrophils in chlamydia-induced pathology is supported and novel methods of depletion must be developed before their role can be specifically determined in vivo.