N
Nikolaus Thuille
Researcher at Innsbruck Medical University
Publications - 27
Citations - 995
Nikolaus Thuille is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: T cell & Transactivation. The author has an hindex of 15, co-authored 27 publications receiving 819 citations. Previous affiliations of Nikolaus Thuille include Altana.
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Journal ArticleDOI
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Marlies Meisel,Reinhard Hinterleitner,Alain Pacis,Li Chen,Zachary M. Earley,Toufic Mayassi,Joseph F. Pierre,Joseph F. Pierre,Jordan D. Ernest,Heather J. Galipeau,Nikolaus Thuille,Romain Bouziat,Manuel Buscarlet,Daina L. Ringus,Yitang Wang,Ye Li,Vu Dinh,Sangman M. Kim,Benjamin D. McDonald,Matthew A. Zurenski,Mark W. Musch,Glaucia C. Furtado,Sergio A. Lira,Gottfried Baier,Eugene B. Chang,A. Murat Eren,A. Murat Eren,Christopher R. Weber,Lambert Busque,Lucy A. Godley,Elena F. Verdu,Luis B. Barreiro,Bana Jabri +32 more
TL;DR: It is shown that bacterial translocation and increased interleukin-6 production, resulting from dysfunction of the small-intestinal barrier, are critical for the development of PMP in mice that lack Tet2 expression in haematopoietic cells.
Journal ArticleDOI
The potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation
Jean-Pierre Evenou,Jürgen Wagner,Gerhard Zenke,Volker Brinkmann,Kathrin Wagner,Jiri Kovarik,Karl Welzenbach,Gabriele Weitz-Schmidt,Christine Guntermann,Harry Towbin,Sylvain Cottens,Sandra Kaminski,Thomas Letschka,Christina Lutz-Nicoladoni,Thomas Gruber,Natascha Hermann-Kleiter,Nikolaus Thuille,Gottfried Baier +17 more
TL;DR: In primary human and mouse T cells, AEB071 treatment effectively abrogated at low nanomolar concentration markers of early T-cell activation, such as interleukin-2 secretion and CD25 expression.
Journal ArticleDOI
Defective IgG2a/2b Class Switching in PKCα−/− Mice
Christa Pfeifhofer,Thomas Gruber,Thomas Letschka,Nikolaus Thuille,Christina Lutz-Nicoladoni,Natascha Hermann-Kleiter,Uschi Braun,Michael Leitges,Gottfried Baier +8 more
TL;DR: In this article, the protein kinase C (PKC) alpha has been implicated in IL-2 cytokine promoter activation in response to Ag receptor stimulation, which is the physiological and nonredundant PKC isotype in signaling pathways that are necessary for T celldependent IFN-gamma production and IgG2a/2b Ab responses.
Journal ArticleDOI
The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity
Natascha Hermann-Kleiter,Thomas Gruber,Christina Lutz-Nicoladoni,Nikolaus Thuille,Friedrich Fresser,Verena Labi,Natalia Schiefermeier,Marei Warnecke,Lukas A. Huber,Andreas Villunger,Gregor Eichele,Sandra Kaminski,Gottfried Baier +12 more
TL;DR: This study establishes NR2F6 as a transcriptional repressor of IL-17 expression in Th17-differentiated CD4(+) T cells in vitro and in vivo.
Journal ArticleDOI
Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes
Nikolaus Thuille,Isabelle Heit,Friedrich Fresser,Nina Krumböck,Birgit Bauer,Sabine Leuthaeusser,Sascha Dammeier,Caroline Graham,Terry D. Copeland,Steve Shaw,Gottfried Baier +10 more
TL;DR: It is concluded that autophosphorylation of PKCθ at Thr‐219 plays an important role in the correct targeting and cellular function of PK Cθ upon antigen receptor ligation.