P
Poonam Dhillon
Researcher at University of Pennsylvania
Publications - 11
Citations - 396
Poonam Dhillon is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney & Kidney disease. The author has an hindex of 3, co-authored 6 publications receiving 133 citations.
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Journal ArticleDOI
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
Ki Wung Chung,Poonam Dhillon,Shizheng Huang,Xin Sheng,Rojesh Shrestha,Chengxiang Qiu,Brett A. Kaufman,Jihwan Park,Liming Pei,Liming Pei,Joseph A. Baur,Matthew Palmer,Katalin Susztak +12 more
TL;DR: Ablation of STING ameliorated kidney fibrosis in mouse models of chronic kidney disease, demonstrating how TFAM sequesters mtDNA to limit the inflammation leading to fibrosis.
Journal ArticleDOI
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
Poonam Dhillon,Jihwan Park,Jihwan Park,Carmen Hurtado del Pozo,Lingzhi Li,Tomohito Doke,Shizheng Huang,Juanjuan Zhao,Hyun Mi Kang,Hyun Mi Kang,Rojesh Shrestra,Michael S. Balzer,Shatakshee Chatterjee,Patrícia Rezende do Prado,Seung Yub Han,Hongbo Liu,Xin Sheng,Pieterjan Dierickx,Kirill Batmanov,Juan P. Romero,Felipe Prosper,Mingyao Li,Liming Pei,Liming Pei,Junhyong Kim,Nuria Montserrat,Katalin Susztak +26 more
TL;DR: Through unbiased cell trajectory analyses, it is shown that PT cell differentiation is altered in kidney disease, and proximal tubule (PT) cells are identified as the key vulnerable cell type.
Journal ArticleDOI
APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis.
Junnan Wu,Ziyuan Ma,Archana Raman,Pazit Beckerman,Poonam Dhillon,Dhanunjay Mukhi,Matthew Palmer,Hua Chang Chen,Cassiane Robinson Cohen,Thomas G. Dunn,John P. Reilly,Nuala J. Meyer,Michael Shahaty,Zoltan Arany,György Haskó,Krzysztof Laudanski,Adriana M. Hung,Katalin Susztak +17 more
TL;DR: This article found that genetic risk variants (RVs) in the trypanolytic factor apolipoprotein L1 (APOL1), present only in individuals of African ancestry, were associated with increased sepsis incidence and severity.
Journal ArticleDOI
It Takes Two to Tango: The Role of Dysregulated Metabolism and Inflammation in Kidney Disease Development.
TL;DR: How inflammatory cytokines and macrophages contribute to epithelial injury and metabolic defects is discussed and the role of mitochondrial damage and cytosolic leakage of the mitochondrial DNA activating the innate immune pathway is discussed.
Journal ArticleDOI
Molecular pathways that drive diabetic kidney disease
TL;DR: In this article , molecular and genetic studies indicate the key role of podocytes and endothelial cells in driving albuminuria and early kidney disease in diabetes, which is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD).