M
Matthias Canault
Researcher at Aix-Marseille University
Publications - 45
Citations - 1927
Matthias Canault is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Platelet & Receptor. The author has an hindex of 21, co-authored 42 publications receiving 1712 citations. Previous affiliations of Matthias Canault include Institut national de la recherche agronomique & Boston Children's Hospital.
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Journal ArticleDOI
von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke.
Bing-Qiao Zhao,Anil K. Chauhan,Anil K. Chauhan,Matthias Canault,Matthias Canault,Ian S. Patten,Janie J. Yang,Michael Dockal,Friedrich Scheiflinger,Denisa D. Wagner,Denisa D. Wagner +10 more
TL;DR: It is reported that deficiency or reduction ofVWF reduces infarct volume up to 2-fold after focal cerebral ischemia in mice, thus showing the importance of VWF in stroke injury and suggesting that recombinant ADAMTS13 could be considered as a new therapeutic agent for prevention and/or treatment of stroke.
Journal ArticleDOI
The shedding activity of ADAM17 is sequestered in lipid rafts
Edwige Tellier,Matthias Canault,Laure Rebsomen,Bernadette Bonardo,Irène Juhan-Vague,Gilles Nalbone,Franck Peiretti +6 more
TL;DR: The data support the idea that one of the mechanisms regulating ADAM17 substrate cleavage involves protein partitioning in lipid rafts, and suggest that the entry of each of these substrates in these particular membrane microdomains is specifically regulated.
Journal ArticleDOI
Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding
Matthias Canault,Matthias Canault,Matthias Canault,Dorsaf Ghalloussi,Dorsaf Ghalloussi,Dorsaf Ghalloussi,Charlotte Grosdidier,Charlotte Grosdidier,Charlotte Grosdidier,Marie Guinier,Claire Perret,Claire Perret,Claire Perret,Nadjim Chelghoum,Marine Germain,Marine Germain,Marine Germain,Hana Raslova,Franck Peiretti,Franck Peiretti,Franck Peiretti,Pierre Morange,Pierre Morange,Pierre Morange,Noémie Saut,Noémie Saut,Noémie Saut,Xavier Pillois,Alan T. Nurden,François Cambien,François Cambien,François Cambien,Anne Pierres,Anne Pierres,Anne Pierres,Timo K. van den Berg,Taco W. Kuijpers,Marie-Christine Alessi,Marie-Christine Alessi,Marie-Christine Alessi,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët +42 more
TL;DR: First case of a human RASGRP2 mutation affecting Rap1 activation in platelets and causing severe bleeding is reported.
Journal ArticleDOI
Microparticles of Human Atherosclerotic Plaques Enhance the Shedding of the Tumor Necrosis Factor-α Converting Enzyme/ADAM17 Substrates, Tumor Necrosis Factor and Tumor Necrosis Factor Receptor-1
Matthias Canault,Aurélie S. Leroyer,Franck Peiretti,Guy Lesèche,Alain Tedgui,Bernadette Bonardo,Marie-Christine Alessi,Chantal M. Boulanger,Gilles Nalbone +8 more
TL;DR: It is shown that human plaque MPs carry catalytically active TACE/ADAM17 and significantly enhance the cell surface processing of the Tace/ADam17 substrates TNF, TNFR-1, and endothelial protein C receptor, suggesting that TACE-adAM17(+) MPs could regulate the inflammatory balance in the culprit lesion.
Journal ArticleDOI
Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation.
Julie Marcotorchino,Julie Marcotorchino,Julie Marcotorchino,Franck Tourniaire,Franck Tourniaire,Franck Tourniaire,Julien Astier,Julien Astier,Julien Astier,Esma Karkeni,Esma Karkeni,Esma Karkeni,Matthias Canault,Matthias Canault,Matthias Canault,Marie-Josèphe Amiot,Marie-Josèphe Amiot,Marie-Josèphe Amiot,David Bendahan,David Bendahan,Monique Bernard,Monique Bernard,Jean-Charles Martin,Jean-Charles Martin,Jean-Charles Martin,Benoît Giannesini,Benoît Giannesini,Jean-François Landrier,Jean-François Landrier,Jean-François Landrier +29 more
TL;DR: The preventive effect of vitamin D3 (VD3) supplementation on onset of obesity in a diet-induced obesity mouse model showed that the VD3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis, showing that VD 3 regulates energy expenditure.