M
Marine Germain
Researcher at University of Bordeaux
Publications - 23
Citations - 1558
Marine Germain is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Genome-wide association study & Expression quantitative trait loci. The author has an hindex of 14, co-authored 23 publications receiving 934 citations. Previous affiliations of Marine Germain include University of Paris & Pierre-and-Marie-Curie University.
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Journal ArticleDOI
Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism
Marine Germain,Marine Germain,Marine Germain,Daniel I. Chasman,Hugoline G. de Haan,Weihong Tang,Sara Lindström,Lu-Chen Weng,Mariza de Andrade,Marieke C H De Visser,Kerri L. Wiggins,Pierre Suchon,Noémie Saut,David M. Smadja,Grégoire Le Gal,Astrid van Hylckama Vlieg,Antonio Fabio Di Narzo,Ke Hao,Christopher P. Nelson,Christopher P. Nelson,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Lasse Folkersen,Ramin Monajemi,Lynda M. Rose,Jennifer A. Brody,Eline Slagboom,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Jean-François Deleuze,Panos Deloukas,Christophe Tzourio,Jean-François Dartigues,Claudine Berr,Kent D. Taylor,Mete Civelek,Per Eriksson,Bruce M. Psaty,Jeanine Houwing-Duitermaat,Alison H. Goodall,Alison H. Goodall,François Cambien,François Cambien,François Cambien,Peter Kraft,Philippe Amouyel,Nilesh J. Samani,Nilesh J. Samani,Saonli Basu,Paul M. Ridker,Frits R. Rosendaal,Christopher Kabrhel,Aaron R. Folsom,John A. Heit,Pieter H. Reitsma,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Nicholas L. Smith,Pierre-Emmanuel Morange +61 more
TL;DR: A meta-analysis of genome-wide association studies to identify additional VTE susceptibility genes uncovered unexpected actors of VTE etiology and pave the way for novel mechanistic concepts of V TE pathophysiology.
Journal ArticleDOI
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism
Sara Lindström,Sara Lindström,Lu Wang,Erin N. Smith,Erin N. Smith,William J. Gordon,Astrid van Hylckama Vlieg,Mariza de Andrade,Jennifer A. Brody,Jack Pattee,Jeffrey Haessler,Ben Michael Brumpton,Ben Michael Brumpton,Daniel I. Chasman,Daniel I. Chasman,Pierre Suchon,Ming-Huei Chen,Constance Turman,Marine Germain,Kerri L. Wiggins,James W. MacDonald,Sigrid Kufaas Brækkan,Sigrid Kufaas Brækkan,Sebastian M. Armasu,Nathan Pankratz,Rebecca D. Jackson,Jonas B. Nielsen,Franco Giulianini,Marja K. Puurunen,Manal Ibrahim,Susan R. Heckbert,Susan R. Heckbert,Scott M. Damrauer,Scott M. Damrauer,Pradeep Natarajan,Derek Klarin,Paul S. de Vries,Maria Sabater-Lleal,Maria Sabater-Lleal,Jennifer E. Huffman,Theo K. Bammler,Kelly A. Frazer,Kelly A. Frazer,Bryan M. McCauley,Kent D. Taylor,James S. Pankow,Alexander P. Reiner,Alexander P. Reiner,Maiken Elvestad Gabrielsen,Jean-François Deleuze,Jean-François Deleuze,Christopher J. O'Donnell,Jihye Kim,Barbara McKnight,Barbara McKnight,Peter Kraft,John-Bjarne Hansen,John-Bjarne Hansen,Frits R. Rosendaal,John A. Heit,Bruce M. Psaty,Bruce M. Psaty,Weihong Tang,Charles Kooperberg,Kristian Hveem,Paul M. Ridker,Paul M. Ridker,P.E. Morange,Andrew D. Johnson,Christopher Kabrhel,Christopher Kabrhel,David-Alexandre Trégouët,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith +74 more
TL;DR: Mendelian randomization analyses suggested that blood traits may contribute to the underlying risk of VTE; for some loci, the association signals are likely mediated through gene expression of nearby genes.
Posted ContentDOI
Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
Josine L. Min,Gibran Hemani,Eilis Hannon,Koen F. Dekkers,Juan E. Castillo-Fernandez,René Luijk,Elena Carnero-Montoro,Elena Carnero-Montoro,Daniel Lawson,Kimberley Burrows,Matthew Suderman,Andrew D. Bretherick,Tom G. Richardson,Johanna Klughammer,Valentina Iotchkova,Gemma C Sharp,Ahmad Al Khleifat,Aleksey Shatunov,Alfredo Iacoangeli,Wendy L. McArdle,Karen M Ho,Ashok Kumar,Ashok Kumar,Ashok Kumar,Cilla Söderhäll,Carolina Soriano-Tárraga,Eva Giralt-Steinhauer,Nabila Kazmi,Dan Mason,Allan F. McRae,David L. Corcoran,Karen Sugden,Silva Kasela,Alexia Cardona,Felix R. Day,Giovanni Cugliari,Clara Viberti,Simonetta Guarrera,Michael Lerro,Richa Gupta,Sailalitha Bollepalli,Pooja R. Mandaviya,Yanni Zeng,Yanni Zeng,Toni-Kim Clarke,Rosie M. Walker,Rosie M. Walker,Vanessa Schmoll,Darina Czamara,Carlos Ruiz-Arenas,Faisal I. Rezwan,Riccardo E. Marioni,Tian Lin,Yvonne Awaloff,Marine Germain,Dylan Aïssi,Ramona A. J. Zwamborn,Kristel R. van Eijk,Annelot M. Dekker,Jenny van Dongen,Jouke-Jan Hottenga,Gonneke Willemsen,Cheng-Jian Xu,Guillermo Barturen,Francesc Català-Moll,Martin Kerick,Carol A. Wang,Phillip E. Melton,Hannah R Elliott,Jean Shin,Manon Bernard,Idil Yet,Melissa C. Smart,T.J. Gorrie-Stone,Christopher Shaw,Ammar Al Chalabi,Ammar Al Chalabi,Susan M. Ring,Göran Pershagen,Erik Melén,Jordi Jimenez-Conde,Jaume Roquer,Debbie A Lawlor,John Wright,Nicholas G. Martin,Grant W. Montgomery,Terrie E. Moffitt,Richie Poulton,Tõnu Esko,Tõnu Esko,Lili Milani,Andres Metspalu,John R. B. Perry,Ken K. Ong,Nicholas J. Wareham,Giuseppe Matullo,Carlotta Sacerdote,Avshalom Caspi,Louise Arseneault,Miina Ollikainen,Jaakko Kaprio,Janine F. Felix,Fernando Rivadeneira,Henning Tiemeier,Henning Tiemeier,Marinus H. van IJzendoorn,Marinus H. van IJzendoorn,André G. Uitterlinden,Vincent W. V. Jaddoe,Vincent W. V. Jaddoe,Chris Haley,Andrew M. McIntosh,Andrew M. McIntosh,Kathryn L. Evans,Kathryn L. Evans,Alison D. Murray,Katri Räikkönen,Jari Lahti,Ellen A. Nohr,Ellen A. Nohr,Thorkild I. A. Sørensen,Torben Hansen,Camilla Schmidt Morgen,Elisabeth B. Binder,Elisabeth B. Binder,Susanne Lucae,Juan R. González,Mariona Bustamante,Jordi Sunyer,John W. Holloway,Wilfried Karmaus,Hongmei Zhang,Ian J. Deary,Naomi R. Wray,John M. Starr,Marian Beekman,Diana van Heemst,P. Eline Slagboom,Pierre-Emmanuel Morange,David-Alexandre Trégouët,Jan H. Veldink,Gareth E. Davies,Eco J. C. de Geus,Dorret I. Boomsma,Judith M. Vonk,Bert Brunekreef,Gerard H. Koppelman,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Rae-Chi Huang,Craig E. Pennell,Joyce B. J. van Meurs,M. Arfan Ikram,Alun D. Hughes,Therese Tillin,Nish Chaturvedi,Zdenka Pausova,Tomáš Paus,Tim D. Spector,Meena Kumari,Leonard C. Schalkwyk,Peter M. Visscher,George Davey Smith,Christoph Bock,Tom R. Gaunt,Jordana T. Bell,Bastiaan T. Heijmans,Jonathan Mill,Caroline L Relton +168 more
TL;DR: Results of DNA methylation-quantitative trait loci (mQTL) analyses on 32,851 participants reveal that the genetic architecture of DNAm levels is highly polygenic and DNAm exhibits signatures of negative and positive natural selection.
Journal ArticleDOI
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
J L Min,Gibran Hemani,Eilis Hannon,Koen F. Dekkers,Juan E. Castillo-Fernandez,René Luijk,Elena Carnero-Montoro,Elena Carnero-Montoro,Daniel Lawson,Kimberley Burrows,Matthew Suderman,Andrew D. Bretherick,Tom G. Richardson,Johanna Klughammer,Valentina Iotchkova,Gemma C Sharp,Ahmad Al Khleifat,Aleksey Shatunov,Alfredo Iacoangeli,Wendy L. McArdle,Karen M Ho,Ashok Kumar,Ashok Kumar,Ashok Kumar,Cilla Söderhäll,C. Soriano-Tarraga,E. Giralt-Steinhauer,Nabila Kazmi,Dan Mason,Allan F. McRae,David L. Corcoran,Karen Sugden,Silva Kasela,Alexia Cardona,Felix R. Day,Giovanni Cugliari,Clara Viberti,Simonetta Guarrera,M. Lerro,Richa Gupta,Sailalitha Bollepalli,Pooja R. Mandaviya,Yanni Zeng,Yanni Zeng,Toni-Kim Clarke,Rosie M. Walker,Rosie M. Walker,Vanessa Schmoll,Darina Czamara,Carlos Ruiz-Arenas,F.I. Rezwan,Riccardo E. Marioni,Riccardo E. Marioni,Tian Lin,Yvonne Awaloff,Marine Germain,D. Aissi,Ramona A. J. Zwamborn,K. van Eijk,Annelot M. Dekker,J. M. van Dongen,Jouke J. Hottenga,Gonneke Willemsen,Cheng-Jian Xu,Cheng-Jian Xu,Guillermo Barturen,Francesc Català-Moll,Martin Kerick,Carol A. Wang,Philip E. Melton,Philip E. Melton,Philip E. Melton,Hannah R Elliott,Jean Shin,Manon Bernard,Idil Yet,Idil Yet,M. Smarts,T.J. Gorrie-Stone,Christopher Shaw,A. al Chalabi,A. al Chalabi,Susan M. Ring,Göran Pershagen,Erik Melén,Jordi Jimenez-Conde,Jaume Roquer,Debbie A Lawlor,John Wright,Nicholas G. Martin,Grant W. Montgomery,Terrie E. Moffitt,Richie Poulton,T Esko,T Esko,Lili Milani,A. Metspalu,John R. B. Perry,Ken K. Ong,Nicholas J. Wareham,Giuseppe Matullo,Carlotta Sacerdote,Salvatore Panico,Avshalom Caspi,Louise Arseneault,F. Gagnon,Miina Ollikainen,Jaakko Kaprio,Janine F. Felix,Fernando Rivadeneira,Henning Tiemeier,Henning Tiemeier,M.H. van IJzendoorn,M.H. van IJzendoorn,André G. Uitterlinden,Vincent W. V. Jaddoe,C. Hale,Andrew M. McIntosh,Andrew M. McIntosh,Kathryn L. Evans,Kathryn L. Evans,Alison D. Murray,Katri Räikkönen,Jari Lahti,Ellen A. Nohr,Ellen A. Nohr,Thorkild I. A. Sørensen,Torben Hansen,Camilla Schmidt Morgen,Camilla Schmidt Morgen,Elisabeth B. Binder,Elisabeth B. Binder,Susanne Lucae,Juan R. González,Mariona Bustamante,Jordi Sunyer,John W. Holloway,Wilfried Karmaus,Hongmei Zhang,Ian J. Deary,Naomi R. Wray,John M. Starr,Marian Beekman,D. VanHeemst,P.E. Slagboom,Pierre-Emmanuel Morange,David-Alexandre Trégouët,Jan H. Veldink,Gail Davies,E.J.C. de Geus,Dorret I. Boomsma,Judith M. Vonk,Bert Brunekreef,Gerard H. Koppelman,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Rae-Chi Huang,Craig E. Pennell,J.B. van Meurs,Ikram,Alun D. Hughes,Therese Tillin,Nish Chaturvedi,Zdenka Pausova,Tomáš Paus,T.D. Spector,Meena Kumari,Leonard C. Schalkwyk,Peter M. Visscher,George Davey Smith,Christoph Bock,Christoph Bock,Tom R. Gaunt,Jordana T. Bell,Bastiaan T. Heijmans,J. Mill,Caroline L Relton +176 more
TL;DR: In this paper, the results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants were presented, identifying genetic variants associated with DNA methylation at 420,509 DNAm sites in blood.
Journal ArticleDOI
Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
Mathieu Lemire,Syed H.E. Zaidi,Maria Ban,Bing Ge,Dylan Aïssi,Marine Germain,Irfahan Kassam,Mike Wang,Brent W. Zanke,Pierre-Emmanuel Morange,David-Alexandre Trégouët,Philip S. Wells,Stephen Sawcer,Steven Gallinger,Tomi Pastinen,Thomas J. Hudson +15 more
TL;DR: Methylation levels at CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) in a panel of lymphocytes from 1,748 individuals, and long-range epigenetic networks uncovered by this approach may be relevant to normal and disease states.