Matthias Westphal

TL;DR: In this paper, physicochemical data of two series of drug analogues of bosentan and vercirnon are documented as part of a comparative study of tert-butyl, pentafluorosulfanyl, trifluoromethyl, bicyclo[1.1]pentanyl, and cyclopropyl-trifluorsulfyl substituents.

TL;DR: Efficient asymmetric syntheses of four photoswitchable Δ9-tetrahydrocannabinol derivatives (azo-THCs) from a central building block 3-Br-THC enable CB1-mediated optical control of inwardly rectifying potassium channels, as well as adenylyl cyclase.

TL;DR: The development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB2R), a promising GPCR to treat tissue injury and inflammatory diseases and hold promise as biomarkers in translational drug discovery is reported.

TL;DR: A versatile ligand platform for the modular design of a collection of highly specific CB2R fluorescent probes, used successfully across ap-plications, species and cell types are reported for the first time.

TL;DR: The design and synthesis of CB2 R-selective cannabinoids along with their in vitro pharmacological characterization (binding and functional studies) are reported, which combine structural features of HU-308 and AM841 to give chimeric ligands that emerge as potentCB2 R agonists with high selectivity over the closely related cannabinoid receptor 1 (CB1 R).