Maudy Walraven

TL;DR: It is demonstrated that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and it is shown that platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively.

TL;DR: In NSCLC, bevacizumab reduced both perfusion and net influx rate of [(11)C]docetaxel within 5 hr and there was no evidence for a substantial improvement in drug delivery to tumors.

TL;DR: A fast, sensitive, universal and accurate method for the determination of four different tyrosine kinase inhibitors from biological material was developed using LC-MS/MS techniques and illustrated with the analysis of samples from a cellular accumulation investigation and from determination of steady state concentrations in clinically treated patients.

TL;DR: Clinical awareness that antiangiogenic treatment can cause GI perforations is critical for current medical practice, but it is also very important to get more insight in its underlying mechanisms so that this life-threatening complication may be prevented in the near future.

TL;DR: Sunitinib significantly inhibits platelet aggregation in patients already after 24 h of first administration, whereas bevacizumab had no effect on aggregation, which may explain the clinically observed bleedings during treatment with antiangiogenic TKIs.